Mitochondrial DNA haplogroup R predicts survival advantage in severe sepsis in the Han population

Genetics in Medicine

Volumn 10, Issue 3, 2008, Pages 187-192

  Yang, Yi ^a   Shou, Zhangfei ^a   Zhang, Ping ^a   He, Qiang ^a   Xiao, Huaying ^a   Xu, Yifang ^a   Li, Chunmei ^a   Chen, Jianghua ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Haplogroup; mtDNA; Severe sepsis

Indexed keywords

MITOCHONDRIAL DNA;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CHINESE; CONTROLLED STUDY; DISEASE SEVERITY; DNA DETERMINATION; DNA POLYMORPHISM; GENE FREQUENCY; HAPLOTYPE; HOSPITAL ADMISSION; HUMAN; INTENSIVE CARE UNIT; LONG TERM CARE; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; SEPSIS; SURVIVAL;

AGED; APACHE; BASE SEQUENCE; CHINA; COHORT STUDIES; DNA PRIMERS; DNA, MITOCHONDRIAL; FEMALE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROGNOSIS; SEPSIS; SURVIVAL;

EID: 40949083529     PISSN: 10983600     EISSN: None     Source Type: Journal    
DOI: 10.1097/GIM.0b013e318163c343     Document Type: Article

References (26)

1. Levy MM, Fink MP, Marshall JC. 2001 SCCM/ESICM/ACCP/ATS/SIS International sepsis definitions conference. Intensive Care Med 2003;29:530-538.
2. Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 2003;348:138-150.
3. Vincent JL. Organ dysfunction in patients with severe sepsis. Surg Infect 2006;7(suppl 2):69-72.
4. Boekstegers P, Weidenhofer S, Kapsner T. Skeletal muscle partial pressure of oxygen in patients with sepsis. Circ Shock 1994;33:17-25.
5. VanderMeer TJ, Wang H, Fink MP. Endotoxin causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic model of septic shock. Crit Care Med 1995;22:1217-1226.
6. Fink MP. Cytopathic hypoxia. Mitochondrial dysfunction as mechanism contribution to organ dysfunction in sepsis. Crit Care Clin 2001;17:219-237.
7. Gellerich FN, Trumbeckaite S, Opalka JR. Mitochondrial dysfunction in sepsis: evidence from bacteraemic baboons and endotoxaemic rabbits. Biosci Rep 2002;22:99-113.
8. Muravchick S, Levy RJ. Clinical implications of mitochondrial dysfunction. Anesthesiology 2006;105:819-837.
9. Ruiz-Pesini E, Mishmar D, Brandon M. Effects of purifying and adaptive selection on regional variation in human mtDNA. Science 2004;303:223-226.
10. Ruiz-Pesini E, Lapena A-C, Diez-Sanchez C. Human mtDNA haplogroups associated with a high or reduced spermatozoa motility. Am J Hum Genet 2000;67:682-696.
11. Van der Walt JM, Dementieva YA, Martin ER. Analysis of European mitochondrial haplogroups with Alzheimer disease risk. Neurosci Lett 2004;365:28-32.
12. Pyle A, Foltynie T, Tiangyou W. Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD. Ann Neurol 2005;57:564-567.
13. Ghezzi D, Marelli C, Achilli A. Mitochondrial DNA haplogroup K is associated with a lower risk of Parkinson's disease in Italians. Eur J Hum Genet 2005;13:748-752.
14. Darvishi K, Sharma S, Bhat AK. Mitochondrial DNA G10398A polymorphism imparts maternal haplogroup N a risk for breast and esophageal cancer. Cancer Lett 2007;249:249-255.
15. Baudouin SV, Saunders D, Tiangyou W. Mitochondrial DNA and survival after sepsis: a prospective study. Lacent 2005;366:2118-2121.
16. Yao YG, Kong QP, Bandelt HJ. Phylogeographic differentiation of mitochondrial DNA in Han Chinese. Am J Hum Genet 2002;70:635-651.
17. Andrews RM, Kubacka I, Chinnery PF. Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA. Nat Genet 1999;23:147.
18. Qing-Peng Kong QP, Bandelt HJ, Sun C. Updating the East Asian mtDNA phylogeny: a prerequisite for the identification of pathogenic mutations. Hum Mol Genet 2006;15:2076-2086.
19. Arcaroli J, Fessler MB, Abraham E. Genetic polymorphisms and sepsis. Shock 2005;4:300-312.
20. Sheu SS, Nauduri D, Anders MW. Targeting antioxidants to mitochondria: a new therapeutic direction. BBA 2006;1762:256-265.
21. Fink MP. Bench-to-bedside review: cytopathic hypoxia. Crit Care 2002;6:491-499.
22. Singer M, Brealey D. Mitochondrial dysfunction in sepsis. Biochem Soc Symp 1999;66:149-166.
23. Brealey D, Brand M, Hargreaves I. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002;360:219-223.
24. Jin L, Su B. Natives or immigrants: modern human origin in East Asia. Nat Rev Genet 2000;1:126-133.
25. Su B, Xiao J, Underhill P. Y-chromosome evidence for a northward migration of modern humans into eastern Asia during the last ice age. Am J Hum Genet 1999;65:1718-1724.
26. Weiss H, Friedrich T, Hofhaus G. The respiratory-chain NADH dehydrogenase (complex I) of mitochondria. Eur J Biochem 1991;197:563-576.