Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: Selective engagement and roles of PI3-K isoform complexes

Apoptosis

Volumn 17, Issue 6, 2012, Pages 566-578

  Beauséjour, Marco ^a   Noël, Dominique ^a   Thibodeau, Sonya ^a   Bouchard, Véronique ^a   Harnois, Charlène ^a   Beaulieu, Jean François ^a   Demers, Marie Josée ^a   Vachon, Pierre H ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

Anoikis; Fak; HIEC; PI3 K; Src; Survival

Indexed keywords

DEOXYRIBONUCLEASE; DNA NUCLEOTIDYLEXOTRANSFERASE; FOCAL ADHESION KINASE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTEGRIN; ISOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE ISOFORM; PROTEIN P110; PROTEIN P55; PROTEIN P85; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANOIKIS; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CRYPT CELL; DNA FRAGMENTATION; ENZYME ACTIVITY; ENZYME INACTIVATION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN INTESTINAL EPITHELIAL CRYPT CELL; INTESTINE EPITHELIUM CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANOIKIS; ANTIGENS, CD29; CELL SURVIVAL; EPITHELIAL CELLS; FOCAL ADHESION KINASE 1; HUMANS; INTESTINES; ISOENZYMES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS PP60(C-SRC); SIGNAL TRANSDUCTION;

EID: 84862494616     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-012-0713-6     Document Type: Article

References (57)

1. Edinger AL, Thompson DB (2004) Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol 16:663-669 (Pubitemid 39463117)
2. Penaloza C, Orlanski S, Ye Y et al (2008) Cell death in mammalian development. Curr Pharm Des 14:184-196 (Pubitemid 351266978)
3. Hellwig CT, Passante E, Rehm M (2011) The molecular machinery regulating apoptosis signal transduction and its implication in human physiology and pathophysiologies. Curr Mol Med 11:31-47
4. Kelly GL, Strasser A (2011) The essential role of evasion from cell death in cancer. Adv Cancer Res 111:39-96
5. Ulukaya E, Acilan C, Yilmaz Y (2011) Apoptosis: why and how does it occur in biology? Cell Biochem Funct 29:468-480
6. Vachon PH (2011) Integrin signaling, cell survival, and anoikis: distinctions, differences, and differentiation. J Signal Transduct 2011:738137
7. Grossmann J (2002) Molecular mechanisms of "detachment-induced apoptosis-anoikis". Apoptosis 7:247-260
8. Martin SS, Vuori K (2004) Regulation of Bcl-2 proteins during anoikis and amorphosis. Biochim Biophys Acta 1692:145-157 (Pubitemid 38891771)
9. Gilmore AP (2005) Anoikis. Cell Death Differ 12:1473-1477
10. Gilmore AP, Owens TW, Foster FM et al (2009) How adhesion signals reach mitochondrial conclusion-ECM regulation of apoptosis. Curr Opin Cell Biol 21:654-661
11. Streuli SH (2009) Integrins and cell-fate determination. J Cell Sci 122:171-177
12. Horbinski C, Mojesky C, Kyprianou N (2010) Live free or die: tales of homeless (cells) in cancer. Am J Pathol 177:1044-1052
13. Stupack DG, Cheresh DA (2002) Get a ligand, get a life: integrins, signaling and cell survival. J Cell Sci 115:3729-3738 (Pubitemid 35203599)
14. Mitra SK, Schlaepfer DD (2006) Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol 18: 516-523 (Pubitemid 44332916)
15. Harburger DS, Calderwood DA (2009) Integrin signalling at a glance. J Cell Sci 122:159-163
16. Osaki M, Oshimura M, Ito H (2004) PI3-K/Akt pathway: its functions and alterations in human cancer. Apoptosis 9:667-676 (Pubitemid 40941196)
17. Duronio V (2008) The life of a cell: apoptosis regulation by the PI3-K/PKB pathway. Biochem J 415:333-344
18. Franke TF (2008) PI3-K/Akt: getting it right matters. Oncogene 27:6473-6488
19. Zhao L, Vogt PK (2008) Class I PI3K in oncogenic cellular transformation. Oncogene 27:5486-5496
20. Engelman JA (2009) Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 9: 550-562
21. Vanhaesebroeck B, Ali K, Bilancio A et al (2005) Signalling by PI3-K isoforms: insights from gene-targeted mice. Trends Biochem Sci 30:194-204 (Pubitemid 40463309)
22. Vanhaesebroeck B, Guillermet-Guibert J, Graupera M et al (2010) The emerging mechanisms of isoform-specific PI3K signalling. Nat Rev Mol Cell Biol 11:329-341
23. Błajecka K, Borgström A, Arcaro A (2011) Phosphatidylinositol 3-kinase isoforms as novel drug targets. Curr Drug Targets 12:1056-1058
24. Ménard D, Beaulieu J-F, Boudreau F et al (2005) Gastrointestinal tract. In: Unsicker K, Kriegelstein K (eds) Cell signaling and growth factors in development II. Wiley-VCH, Verlag, pp 755-790
25. Edelblum KL, Yan F, Yamaoka T et al (2006) Regulation of apoptosis during homeostasis and disease in the intestinal epithelium. Inflamm Bowel Dis 12:413-424
26. Vachon PH (2006) Cell survival: differences and differentiation. Med Sci (Paris) 22:423-429
27. Saif MW, Chu E (2010) Biology of colorectal cancer. Cancer J 16:196-201
28. Gauthier R, Harnois C, Drolet J-F et al (2001) Human intestinal epithelial cell survival: differentiation state-specific control mechanisms. Am J Physiol Cell Physiol 280:C1540-C1554
29. Vachon PH, Harnois C, Grenier A et al (2002) Differentiation state-selective roles of p38 isoforms in human intestinal epithelial cell anoikis. Gastroenterology 123:1980-1991 (Pubitemid 35414331)
30. Dufour G, Demers M-J, Gagné D et al (2004) Human intestinal epithelial cell survival and anoikis. Differentiation state-distinct regulation and roles of protein kinase B/Akt isoforms. J Biol Chem 279:44113-44122 (Pubitemid 39403045)
31. Harnois C, Demers M-J, Bouchard V et al (2004) Human intestinal epithelial crypt cell survival and death: complex modulations of Bcl-2 homologs by Fak, PI3-K/Akt-1, MEK/Erk, and p38 signaling pathways. J Cell Physiol 198:209-222 (Pubitemid 38139312)
32. Bouchard V, Harnois C, Demers M-J et al (2008) β1 integrin/Fak/ Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms. Apoptosis 13:531-542
33. Bouchard V, Demers M-J, Thibodeau S et al (2007) Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways. J Cell Physiol 212:717-728 (Pubitemid 47271883)
34. Michl P, Downward J (2005) Mechanisms of disease: PI3K/AKT signaling in gastrointestinal cancers. Z Gastroenterol 43:1133-1139 (Pubitemid 41584815)
35. Le Tourneau C, Faivre S, Raymond E (2007) The role of integrins in colorectal cancer. Oncology 21:21-24
36. Chen J (2008) Is Src the key to understanding metastasis and developing new treatments for colon cancer? Nat Clin Pract Gastroenterol Hepatol 5:306-307
37. Golubovskaya VM, Kweh FA, Cance WG (2009) Focal adhesion kinase and cancer. Histol Histopathol 24:503-510
38. Zhang J, Roberts TM, Shivdasani RA (2011) Targeting PI3K signaling as a therapeutic approach for colorectal cancer. Gastroenterology 141:50-61
39. Demers M-J, Thibodeau S, Noël D et al (2009) Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1. J Cell Biochem 107:639-654
40. Rychahou PG, Jackson LN, Silva SR et al (2006) Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma. Ann Surg 243:833-844
41. Ihle NT, Powis G, Kopetz S (2011) PI-3-Kinase inhibitors in colorectal cancer. Curr Cancer Drug Targets 11:190-198
42. Hawkins PT, Stephens LR, Suire S et al (2010) PI3K signaling in neutrophils. Curr Top Microbiol Immunol 346:183-202
43. Perreault N, Beaulieu J-F (1996) Use of the dissociating enzyme thermolysin to generate viable human normal intestinal epithelial cell cultures. Exp Cell Res 224:354-364 (Pubitemid 26140569)
44. Pageot L-P, Perreault N, Basora N et al (2000) Human cell models to study small intestinal functions. Recapitulation of the crypt-villus axis. Microsc Res Tech 49:394-406 (Pubitemid 30407775)
45. Gagné D, Groulx J-F, Benoit YD et al (2010) Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism. J Cell Physiol 222:387-400
46. Lévy E, Delvin E, Ménard D, Beaulieu JF (2009) Functional development of human fetal gastrointestinal tract. Methods Mol Biol 550:205-224
47. Benoit YD, Larrivée J-F, Groulx J-F et al (2010) Integrin alpha8beta1 confers anoikis susceptibility to human intestinal epithelial crypt cells. Biochem Biophys Res Commun 399: 434-439
48. Beaulieu J-F, Ménard D (2012) Isolation, characterization, and culture of normal human intestinal crypt and villus cells. Methods Mol Biol 806:157-173
49. Frisch SM (1999) Methods for studying anoikis. In: Howlett AR (ed) Methods in molecular biology, vol 129: integrin protocols. Humana Press, Totowa, pp 251-256
50. Jia S, Roberts TM, Zhao JJ (2009) Should individual PI3 kinase isoforms be targeted in cancer? Curr Opin Cell Biol 21:199-208
51. Samuels Y, Ericson K (2006) Oncogenic PI3-K and its role in cancer. Curr Opin Oncol 18:77-82 (Pubitemid 43740454)
52. Bénistant C, Chapuis H, Roche S (2000) A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alphap110beta) in de novo DNA synthesis of human colon carcinoma cells. Oncogene 19:5083-5090
53. Inukai K, Funaki M, Anai M et al (2001) Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations. FEBS Lett 490:32-38 (Pubitemid 32126639)
54. Cabodi S, Di Stefano P, Leal Mdel P et al (2010) Integrins and signal transduction. Adv Exp Med Biol 674:43-54
55. Du K, Tsichlis PN (2005) Regulation of the Akt kinase by interacting proteins. Oncogene 24:7401-7409 (Pubitemid 41637980)
56. Bozulic L, Hemmings BA (2009) PIKKing on PKB: regulation of PKB activity by phosphorylation. Curr Opin Cell Biol 21: 256-261
57. Hers I, Vincent EE, Tavaré JM (2011) Akt signalling in health and disease. Cell Signal 23:1515-1527