Integrin α8β1 confers anoikis susceptibility to human intestinal epithelial crypt cells

Biochemical and Biophysical Research Communications

Volumn 399, Issue 3, 2010, Pages 434-439

  Benoit, Yannick D ^a   Larrivée, Jean François ^a   Groulx, Jean François ^a   Stankova, Jana ^a   Vachon, Pierre H ^a   Beaulieu, Jean François ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

Anoikis; Crypt; FAK; Integrin; Intestine

Indexed keywords

ALPHA INTEGRIN; INTEGRIN ALPHA8BETA1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PAXILLIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROPIDIUM IODIDE; PROTEIN KINASE B; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; VINCULIN; FOCAL ADHESION KINASE 1; INTEGRIN; PTK2 PROTEIN, HUMAN;

ANOIKIS; ARTICLE; CRYPT CELL; FLOW CYTOMETRY; FOCAL ADHESION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOFLUORESCENCE; INTESTINE EPITHELIUM CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; CELL CULTURE; CYTOLOGY; GENE SILENCING; GENETICS; INTESTINE MUCOSA; METABOLISM; PHYSIOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANOIKIS; CELLS, CULTURED; FOCAL ADHESION KINASE 1; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTEGRINS; INTESTINAL MUCOSA; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 77956177279     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.07.107     Document Type: Article

References (41)

1. Clark E.A., Brugge J.S. Integrins and signal transduction pathways: the road taken. Science 1995, 268:233-239.
2. Beaulieu J.F. Integrins and human intestinal cell functions. Front. Biosci. 1999, 4:D310-D321.
3. Giancotti F.G., Ruoslahti E. Integrin signaling. Science 1999, 285:1028-1032.
4. Reddig P.J., Juliano R.L. Clinging to life: cell to matrix adhesion and cell survival. Cancer Metastasis Rev. 2005, 24:425-439.
5. Benoit Y.D., Lussier C., Ducharme P.A., Sivret S., Schnapp L.M., Basora N., Beaulieu J.F. Integrin alpha8beta1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanism. Biol. Cell 2009, 101:695-708.
6. Demers M.J., Thibodeau S., Noel D., Fujita N., Tsuruo T., Gauthier R., Arguin M., Vachon P.H. Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1. J. Cell. Biochem. 2009, 107:639-654.
7. Pageot L.P., Perreault N., Basora N., Francoeur C., Magny P., Beaulieu J.F. Human cell models to study small intestinal functions: recapitulation of the crypt-villus axis. Microsc. Res. Tech. 2000, 49:394-406.
8. Grossmann J., Walther K., Artinger M., Kiessling S., Scholmerich J. Apoptotic signaling during initiation of detachment-induced apoptosis (" anoikis" ) of primary human intestinal epithelial cells. Cell Growth Differ. 2001, 12:147-155.
9. Vachon P.H., Harnois C., Grenier A., Dufour G., Bouchard V., Han J., Landry J., Beaulieu J.F., Vezina A., Dydensborg A.B., Gauthier R., Cote A., Drolet J.F., Lareau F. Differentiation state-selective roles of p38 isoforms in human intestinal epithelial cell anoikis. Gastroenterology 2002, 123:1980-1991.
10. Potten C.S. Epithelial cell growth and differentiation: II. Intestinal apoptosis. Am. J. Physiol. 1997, 273:G253-G257.
11. Thomson A.B., Drozdowski L., Iordache C., Thomson B.K., Vermeire S., Clandinin M.T., Wild G. Small bowel review: normal physiology, part 2. Dig. Dis. Sci. 2003, 48:1565-1581.
12. Bouchard V., Harnois C., Demers M.J., Thibodeau S., Laquerre V., Gauthier R., Vezina A., Noel D., Fujita N., Tsuruo T., Arguin M., Vachon P.H. B1 integrin/Fak/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms. Apoptosis 2008, 13:531-542.
13. Bouchard V., Demers M.J., Thibodeau S., Laquerre V., Fujita N., Tsuruo T., Beaulieu J.F., Gauthier R., Vezina A., Villeneuve L., Vachon P.H. Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways. J. Cell. Physiol. 2007, 212:717-728.
14. Lim S.T., Mikolon D., Stupack D.G., Schlaepfer D.D. FERM control of FAK function: implications for cancer therapy. Cell Cycle 2008, 7:2306-2314.
15. Subauste M.C., Pertz O., Adamson E.D., Turner C.E., Junger S., Hahn K.M. Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. J. Cell Biol. 2004, 165:371-381.
16. Ziegler W.H., Liddington R.C., Critchley D.R. The structure and regulation of vinculin. Trends Cell Biol. 2006, 16:453-460.
17. Stupack D.G., Cheresh D.A. Get a ligand, get a life: integrins, signaling and cell survival. J. Cell Sci. 2002, 115:3729-3738.
18. Xu W., Baribault H., Adamson E.D. Vinculin knockout results in heart and brain defects during embryonic development. Development 1998, 125:327-337.
19. Turner C.E. Paxillin interactions. J. Cell Sci. 2000, 113(Pt. 23):4139-4140.
20. Farias E., Lu M., Li X., Schnapp L.M. Integrin alpha8beta1-fibronectin interactions promote cell survival via PI3 kinase pathway. Biochem. Biophys. Res. Commun. 2005, 329:305-311.
21. Perreault N., Beaulieu J. Use of the dissociating enzyme thermolysin to generate viable human normal intestinal epithelial cell cultures. Exp. Cell Res. 1996, 224:354-364.
22. Tremblay E., Auclair J., Delvin E., Levy E., Menard D., Pshezhetsky A.V., Rivard N., Seidman E.G., Sinnett D., Vachon P.H., Beaulieu J.F. Gene expression profiles of normal proliferating and differentiating human intestinal epithelial cells: a comparison with the Caco-2 cell model. J. Cell. Biochem. 2006, 99:1175-1186.
23. Benoit Y.D., Pare F., Francoeur C., Jean D., Tremblay E., Boudreau F., Escaffit F., Beaulieu J.F. Cooperation between HNF-1alpha, Cdx2, and GATA-4 in initiating an enterocytic differentiation program in a normal human intestinal epithelial progenitor cell line. Am. J. Physiol. Gastrointest. Liver Physiol. 2010, 298:G504-G517.
24. Dydensborg A.B., Herring E., Auclair J., Tremblay E., Beaulieu J.F. Normalizing genes for quantitative RT-PCR in differentiating human intestinal epithelial cells and adenocarcinomas of the colon. Am. J. Physiol. Gastrointest. Liver Physiol. 2006, 290:G1067-G1074.
25. Vainionpaa N., Kikkawa Y., Lounatmaa K., Miner J.H., Rousselle P., Virtanen I. Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells. Am. J. Physiol. Cell Physiol. 2006, 290:C764-C775.
26. Zargham R., Thibault G. Alpha8beta1 Integrin expression in the rat carotid artery: involvement in smooth muscle cell migration and neointima formation. Cardiovasc. Res. 2005, 65:813-822.
27. Dufour G., Demers M.J., Gagne D., Dydensborg A.B., Teller I.C., Bouchard V., Degongre I., Beaulieu J.F., Cheng J.Q., Fujita N., Tsuruo T., Vallee K., Vachon P.H. Human intestinal epithelial cell survival and anoikis. Differentiation state-distinct regulation and roles of protein kinase B/Akt isoforms. J. Biol. Chem. 2004, 279:44113-44122.
28. Escaffit F., Perreault N., Jean D., Francoeur C., Herring E., Rancourt C., Rivard N., Vachon P.H., Pare F., Boucher M.P., Auclair J., Beaulieu J.F. Repressed E-cadherin expression in the lower crypt of human small intestine: a cell marker of functional relevance. Exp. Cell Res. 2005, 302:206-220.
29. Tewari M., Quan L.T., O'Rourke K., Desnoyers S., Zeng Z., Beidler D.R., Poirier G.G., Salvesen G.S., Dixit V.M. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 1995, 81:801-809.
30. Germain M., Affar E.B., D'Amours D., Dixit V.M., Salvesen G.S., Poirier G.G. Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. J. Biol. Chem. 1999, 274:28379-28384.
31. Zhang Y., Lu H., Dazin P., Kapila Y. Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase. J. Biol. Chem. 2004, 279:48342-48349.
32. Tumbarello D.A., Brown M.C., Turner C.E. The paxillin LD motifs. FEBS Lett. 2002, 513:114-118.
33. Haramis A.P., Begthel H., van den Born M., van Es J., Jonkheer S., Offerhaus G.J., Clevers H. De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science 2004, 303:1684-1686.
34. Sato T., Vries R.G., Snippert H.J., van de Wetering M., Barker N., Stange D.E., van Es J.H., Abo A., Kujala P., Peters P.J., Clevers H. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 2009, 459:262-265.
35. Barker N., Ridgway R.A., van Es J.H., van de Wetering M., Begthel H., van den Born M., Danenberg E., Clarke A.R., Sansom O.J., Clevers H. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 2009, 457:608-611.
36. Mohri T., Adachi Y., Ikehara S., Hioki K., Tokunaga R., Taketani S. Activated Rac1 selectively up-regulates the expression of integrin alpha6beta4 and induces cell adhesion and membrane ruffles of nonadherent colon cancer Colo201 cells. Exp. Cell Res. 1999, 253:533-540.
37. Samuels Y., Diaz L.A., Schmidt-Kittler O., Cummins J.M., Delong L., Cheong I., Rago C., Huso D.L., Lengauer C., Kinzler K.W., Vogelstein B., Velculescu V.E. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell 2005, 7:561-573.
38. Dang L.H., Chen F., Ying C., Chun S.Y., Knock S.A., Appelman H.D., Dang D.T. CDX2 has tumorigenic potential in the human colon cancer cell lines LOVO and SW48. Oncogene 2006, 25:2264-2272.
39. Bates R.C., Pursell B.M., Mercurio A.M. Epithelial-mesenchymal transition and colorectal cancer: gaining insights into tumor progression using LIM 1863 cells. Cells Tissues Organs 2007, 185:29-39.
40. Lemieux E., Bergeron S., Durand V., Asselin C., Saucier C., Rivard N. Constitutively active MEK1 is sufficient to induce epithelial-to-mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis. Int. J. Cancer 2009, 125:1575-1586.
41. Morozevich G.E., Kozlova N.I., Chubukina A.N., Berman A.E. Role of integrin alphavbeta3 in substrate-dependent apoptosis of human intestinal carcinoma cells. Biochemistry (Mosc.) 2003, 68:416-423.