Scutellaria extract and wogonin inhibit tumor-mediated induction of T reg cells via inhibition of TGF-β1 activity

Cancer Immunology, Immunotherapy

Volumn 61, Issue 5, 2012, Pages 701-711

  Dandawate, Sagar ^a   Williams, Linford ^a   Joshee, Nirmal ^b   Rimando, Agnes M ^c   Mittal, Sandeep ^a   Thakur, Archana ^d   Lum, Lawrence G ^d   Parajuli, Prahlad ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FORT VALLEY STATE UNIVERSITY   (United States)

^c NATURAL PRODUCTS UTILIZATION RESEARCH UNIT   (United States)

^d WAYNE STATE UNIVERSITY   (United States)

Author keywords

Flavonoids; Glioma; Regulatory T cells; Scutellaria; TGF ; Wogonin

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; HERBACEOUS AGENT; INTERLEUKIN 10; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PLACEBO; SCUTELLARIA OCMULGEE EXTRACT; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; WOGONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG ISOLATION; DRUG TARGETING; GLIOBLASTOMA; IN VITRO STUDY; LYMPHOCYTE CULTURE; LYMPHOCYTE FUNCTION; NONHUMAN; PLANT LEAF; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REGULATORY T LYMPHOCYTE; SCUTELLARIA; SCUTELLARIA OCMULGEE; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; FLAVANONES; GLIOMA; GLYCOGEN SYNTHASE KINASE 3; INTERLEUKIN-10; INTERLEUKIN-2; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLANT EXTRACTS; PLANT LEAVES; RATS; SCUTELLARIA; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84862491992     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-011-1130-3     Document Type: Article

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