Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells

BMC Complementary and Alternative Medicine

Volumn 6, Issue , 2006, Pages

  Scheck, Adrienne C ^a   Perry, Krya ^a,b   Hank, Nicole C ^a   Clark, W Dennis ^b  

^a BARROW NEUROLOGICAL INSTITUTE   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CARMUSTINE; FLAVONOID; SCUTELLARIA BAICALENSIS EXTRACT; TRYPAN BLUE;

ANALYSIS OF VARIANCE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER ADJUVANT THERAPY; CANCER CELL CULTURE; CANCER INHIBITION; CELL METABOLISM; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; PLANT ROOT; RECURRENT CANCER; SCUTELLARIA BAICALENSIS;

ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; CARMUSTINE; CELL PROLIFERATION; CELL SURVIVAL; DRUG THERAPY, COMBINATION; GLIOMA; HUMANS; NEUROGLIA; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; SCUTELLARIA BAICALENSIS; TREATMENT OUTCOME; TUMOR CELLS, CULTURED;

EID: 33748351137     PISSN: 14726882     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-6-27     Document Type: Article

References (50)

1. American Cancer Society: Cancer Facts and Figures 2006. Atlanta, American Cancer Society; 2006.
2. Mousseau M, Chauvin C, Nissou MF, Chaffanet M, Plantaz D, Pasquier B, Schaerer R, Benabid A: A study of the expression of four chemoresistance-related genes in human primary and metastatic brain tumours. Eur J Cancer 1993, 29A:753-759.
3. Scheck AC, Shapiro JR, Coons SW, Norman SA, Johnson PC: Biological and molecular analysis of a low grade recurrence of a glioblastoma multiforme. Clin Cancer Res 1996, 2:187-199.
4. Seigler DS: Plant Secondary Metabolism Boston: Kluwer Academic; 1998.
5. Harborne JB: Arsenal for survival: secondary plant products. Taxon 2000, 49:435-449.
6. Yang CS, Landau JM, Huang MT, Newmark HL: Inhibition of carcinogenesis by dietary polyphenolic compounds. Ann Rev Nutr 2001, 21:381-406.
7. Kuo SM: Dietary flavonoid and cancer prevention: evidence and potential mechanism. Crit rev Oncogenesis 1997, 8:47-69.
8. Lahiri-Chatterjee M, Katiyar SK, Mohan RR, Agarwal K: A flavonoid antioxidant, silymarin, affords exceptionally high protection against tumor promotion in the SENCAR mouse skin tumorigenesis model. Cancer Res 1999, 59:622-632.
9. Ingram D, Sanders K, Kolybaba M, Lopez D: Case control study of phyto-oestrogens and breast cancer. Lancet 1997, 350:990-994.
10. Messina MJ, Persky V, Setchell KDR, Barnes S: Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr Cancer 1994, 21:113-131.
11. Barnes S, Peterson TG, Coward L: Rationale for the use of genistein-containing soy matrices in chemoprevention trials for breast and prostate cancer. J Cell Biochem 1995, 22S:181-187.
12. Khoshyomn S, Manske GC, Lew SM, Wald SL, Penar PL: Synergistic action of genistein and cisplatin on growth inhibition and cytotoxicity of human medulloblastoma cells. Pediatr Neurosurg 2000, 33:123-131.
13. Khoshyomn S, Nathan D, Manske GC, Osler TM, Penar PL: Synergistic effect of genistein and BCNU on growth inhibition and cytotoxicity of glioblastoma cells. J Neurooncol 2002, 57:193-200.
14. Chung CP, Park JB, Bae KH: Pharmocological effects of methanolic extract from the root of Scutellaria baicalensis and its flavonoids on human gingival fibroblast. Planta Med 1995, 61:150-153.
15. Maloney D: The American Association of Oriental Medicine's Complete Guide to Chinese Herbal Medicine. New York: The Berkley Publishing Group; 1998.
16. Fei Y, Xui L, Yi J, Zhang W, Zhang DY: Anticancer activity of Scutellaria baicalensis and its potential mechanism. J Altem Complement Med 2002, 8:567-572.
17. Tajiri H, Kozaiwa K, Ozaki Y, Miki K, Shimuzu K, Okada S: Effect of sho-saiko-to (xiao-chai-hu-tang) on HBeAg clearance in children with chronic hepatitis B virus infection with sustained liver disease. Am J Chin Med 1991, 19:121-129.
18. 1 phase. Cancer Res 1994, 54:448-454.
19. Bigler D, Guiding KM, Dann R, Sheabar FZ, Conaway MR, Theodorescu D: Gene profiling and promoter reporter assays: novel tools for comparing the biological effects of botanical extracts on human prostate cancer cells and understanding their mechanisms of action. Oncogene 2003, 22:1261-1272.
20. Bonham M, Posakony J, Coleman I, Montgomery B, Simon J, Nelson PS: Characterization of chemical constituents in Scutellaria balcalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Clin Cancer Res 2005, 11:3905-3914.
21. Chan FL, Choi HL, Chen ZY, Chan PS, Huang Y: Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin. Cancer Lett 2000, 160:219-228.
22. Chen S, Ruan Q, Bedner E, Deptala A, Wang X, Hsieh TC, Traganos F, Darzynkiewicz Z: Effects of the flavonold baicalin and its metabolite baicalein on androgen receptor expression, cell cycle progression and apoptosis of prostate cancer cell lines. Cell Prolif 2001, 34:293-304.
23. Ikezoe T, Chen SS, Yang Y, Heber D, Taguchi H, Koeffier HP: PC-SPES: Molecular mechanism to induce apoptosis and down-regulate expression of PSA in LNCaP human prostate cancer cells. Int J Oncol 2003, 23:1461-1470.
24. Kobayashi T, Nakata T, Kuzumaki T: Effect of flavonoids on cell cycle progression in prostate cancer cells. Cancer Lett 2002, 176:17-23.
25. Lu X, Guo J, Hsieh TC: PC-SPES inhibits cell proliferation by modulating p21, cyclins D, E and B and multiple cell cycle-related genes in prostate cancer cells. Cell Cycle 2003, 2:59-63.
26. Sadava D, Winesburg J: Contaminants of PC-SPES are not responsible for cytotoxicity in human small-cell lung carcinoma cells. Cancer Lett 2005, 220:171-175.
27. Choi SU, Ryu SY, Yoon SK, Jung NP, Park SH, Kim KH, Choi EJ, Lee CO: Effects of flavonoids on the growth and cell cycle of cancer cells. Anticancer Res 1999, 19:5229-5233.
28. Liu JJ, Huang TS, Cheng WF, Lu FJ: Baicalein and baicalin are potent inhibitors of angiogenesis: Inhibition of endothelial cell proliferation, migration and differentiation. Int J Cancer 2003, 106:559-565.
29. Chung VQ, Tattersall M, Cheung HT: Interactions of a herbal combination that inhibits growth of prostate cancer cells. Cancer Chemother Pharmacol 2004, 53:384-390.
30. Cordell GA: PC-SPES: a brief overview. Integr Cancer Ther 2002, 1:271-286.
31. Hsieh TC, Lu X, Chea J, Wu JM: Prevention and management of prostate cancer using PC-SPES: a scientific perspective. J Nutr 2002, 132:3513S-3517S.
32. Ikezoe T, Chen S, Saito T, Asou H, Kyo T, Tanosaki S, Heber D, Taguchi H, Koeffier HP: PC-SPES decreases proliferation and induces differentiation and apoptosis of human acute myeloid leukemia cells. Int J Oncol 2003, 23:1203-1211.
33. Meyer JP, Gillatt DA: PC-SPES: a herbal therapy for the treatment of hormone refractory prostate cancer. Prostate Cancer Prostatic Dis 2002, 5:13-15.
34. Oh WK, Kantoff PW, Weinberg V, Jones G, Rini BI, Derynck MK, Bok R, Smith MR, Bubley GJ, Rosen RT, DiPaola RS, Small EJ: Prospective, multicenter, randomized phase II trial of the herbal supplement, PC-SPES, and diethylstilbestrol in patients with androgen-independent prostate cancer. J Clin Oncol 2004, 22:3705-3712.
35. Richardson MA, Straus SE: Complementary and Alternative Medicine: Opportunities and Challenges for Cancer Management and Research. Sem Onc 2002, 29:531-545.
36. Huang HC, Hsieh LM, Chen HW, Lin YS, Chen JS: Effects of baicalein and esculetin on transduction signals and growth factors expression in T-lymphoid leukemia cells. Eur J Pharmacol 1994, 268:73-78.
37. Motoo Y, Sawabu N: Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma cell lines. Cancer Lett 1994, 86:91-95.
38. Suk K, Lee H, Kang SS, Cho GJ, Choi WS: Flavonoid baicalein attenuates activation-induced cell death of brain microglia. J Pharmacol Exp Ther 2003, 305:638-645.
39. Asch AS, Leung LLK, Shapiro JR, Nachman RL: Human brain glial cells synthesize thrombospondin. Proc Natl Acad Sci USA 1986, 83:2904-2908.
40. Scheck AC, Mehta BM, Beikman MK, Shapiro JR: BCNU-resistant human glioma cells with over-representation of chromosomes 7 and 22 demonstrate increased copy number and expression of platelet-derived growth factor genes. Genes, Chromosomes & Cancer 1993, 8:137-148.
41. Shapiro JR, Pu P-Y, Mohamed AN, Galicich JH, Ebrahim SAD, Shapiro WR: Chromosome number and carmustine sensitivity in human gliomas. Cancer 1993, 71:4007-4021.
42. VassarStats Statistical Computation website 2006 [http://faculty.assar.edu/lowry/VassarStats.html].
43. Lee MJ, Wang CJ, Tsai YY, Hwang JM, Lin WL, Tseng TH, Chu CY: Inhibitory effect of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in benzo[a]pyrene-initiated CD-I mouse skin by baicalein. Nutr Cancer 1999, 34:185-191.
44. Aung HH, Dey L, Mehendale S, Xie JT, Wu JA, Yuan CS: Scutellaria baicalensis extract decreases cisplatin-induced pica in rats. Cancer Chemother Pharmacol 2003, 52:453-458.
45. Cipak L, Rauko P, Miadokova E, Cipakova I, Novotny L: Effects of flavonoids on cisplatin-induced apoptosis of HL-60 and L1210 leukemia cells. Leuk Res 2003, 27:65-72.
46. Bhaskara VK, Panigrahi M, Challa S, Babu PP: Comparative status of activated ERKI/2 and PARP cleavage in human gliomas. Neuropathology 2005, 25:48-53.
47. Momota H, Nerio E, Holland EC: Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. Cancer Res 2005, 65:7429-7435.
48. Sturia LM, Cowan CW, Guenther L, Castellino RC, Kim JY, Pomeroy SL: A novel role for extracellular signal-regulated kinase 5 and myocyte enhancer factor 2 in medulloblastoma cell death. Cancer Res 2005, 65:5683-5689.
49. Choi J, Conrad CC, Malakowsky CA, Talent JM, Yuan CS, Gracy RW: Flavones from Scutellaria baicalensis Georgi attenuate apoptosis and protein oxidation in neuronal cell lines. Biochim Biophys Acta 2002, 1571:201-210.
50. Lee SW, Song GS, Kwon CH, Kim YK: Beneficial effect of flavonoid baicalein in cisplatin-induced cell death of human glioma cells. Neurosci Lett 2005, 382:71-75.