메뉴 건너뛰기




Volumn 22, Issue 4, 2012, Pages 454-471

Axonopathy is associated with complex axonal transport defects in a model of multiple sclerosis

Author keywords

Axonopathy; Multiple sclerosis; TMEV; Transport defects

Indexed keywords

BETA TUBULIN; KINESIN 5; TAU PROTEIN;

EID: 84862488270     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2011.00541.x     Document Type: Article
Times cited : (33)

References (62)
  • 1
    • 0032567765 scopus 로고    scopus 로고
    • Cytoplasmic dynein and dynactin are required for the transport of microtubules into the axon
    • DOI 10.1083/jcb.140.2.391
    • Ahmad FJ, Echeverri CJ, Vallee RB, Baas PW (1998) Cytoplasmic dynein and dynactin are required for the transport of microtubules into the axon. J Cell Biol 140:391-401. (Pubitemid 28078402)
    • (1998) Journal of Cell Biology , vol.140 , Issue.2 , pp. 391-401
    • Ahmad, F.J.1    Echeverri, C.J.2    Vallee, R.B.3    Baas, P.W.4
  • 2
    • 77649133016 scopus 로고    scopus 로고
    • NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death
    • Alano CC, Garnier P, Ying W, Higashi Y, Kauppinen TM, Swanson RA (2010) NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death. J Neurosci 30:2967-2978.
    • (2010) J Neurosci , vol.30 , pp. 2967-2978
    • Alano, C.C.1    Garnier, P.2    Ying, W.3    Higashi, Y.4    Kauppinen, T.M.5    Swanson, R.A.6
  • 3
    • 4043165678 scopus 로고    scopus 로고
    • Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
    • DOI 10.1126/science.1098014
    • Araki T, Sasaki Y, Milbrandt J (2004) Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 305:1010-1013. (Pubitemid 39071777)
    • (2004) Science , vol.305 , Issue.5686 , pp. 1010-1013
    • Araki, T.1    Sasaki, Y.2    Milbrandt, J.3
  • 4
    • 0033167050 scopus 로고    scopus 로고
    • Cyclin dependent kinase-5 (CDK-5) phosphorylates neurofilament heavy (NF-H) chain to generate epitopes for antibodies that label neurofilament accumulations in amyotrophic lateral sclerosis (ALS) and is present in affected motor neurones in ALS
    • DOI 10.1016/S0278-5846(99)00044-5, PII S0278584699000445
    • Bajaj NP, al-Sarraj ST, Leigh PN, Anderson V, Miller CC (1999) Cyclin dependent kinase-5 (CDK-5) phosphorylates neurofilament heavy (NF-H) chain to generate epitopes for antibodies that label neurofilament accumulations in amyotrophic lateral sclerosis (ALS) and is present in affected motor neurones in ALS. Prog Neuropsychopharmacol Biol Psychiatry 23:833-850. (Pubitemid 29416758)
    • (1999) Progress in Neuro-Psychopharmacology and Biological Psychiatry , vol.23 , Issue.5 , pp. 833-850
    • Bajaj, N.P.S.1    Al-Sarraj, S.T.2    Leigh, P.N.3    Anderson, V.4    Miller, C.C.J.5
  • 5
    • 0037316303 scopus 로고    scopus 로고
    • A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    • DOI 10.1093/bioinformatics/19.2.185
    • Bolstad BM, Irizarry RA, Astrand M, Speed TP (2003) A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19:185-193. (Pubitemid 36181903)
    • (2003) Bioinformatics , vol.19 , Issue.2 , pp. 185-193
    • Bolstad, B.M.1    Irizarry, R.A.2    Astrand, M.3    Speed, T.P.4
  • 6
    • 27644591304 scopus 로고    scopus 로고
    • Axon degeneration mechanisms: Commonality amid diversity
    • Coleman M (2005) Axon degeneration mechanisms: commonality amid diversity. Nat Rev Neurosci 6:889-898.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 889-898
    • Coleman, M.1
  • 7
    • 0029004898 scopus 로고
    • Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis
    • Collard JF, Cote F, Julien JP (1995) Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis. Nature 375:61-64.
    • (1995) Nature , vol.375 , pp. 61-64
    • Collard, J.F.1    Cote, F.2    Julien, J.P.3
  • 8
    • 33947724269 scopus 로고    scopus 로고
    • Neuronal death: where does the end begin?
    • DOI 10.1016/j.tins.2007.02.004, PII S0166223607000422
    • Conforti L, Adalbert R, Coleman MP (2007) Neuronal death: where does the end begin? Trends Neurosci 30:159-166. (Pubitemid 46505033)
    • (2007) Trends in Neurosciences , vol.30 , Issue.4 , pp. 159-166
    • Conforti, L.1    Adalbert, R.2    Coleman, M.P.3
  • 9
    • 29844455077 scopus 로고    scopus 로고
    • A comparison of immunohistochemical and silver staining methods for the detection of diffuse plaques in the aged canine brain
    • DOI 10.1016/j.neurobiolaging.2005.02.017, PII S0197458005001661
    • Czasch S, Paul S, BaumgartnerW(2006) A comparison of immunohistochemical and silver staining methods for the detection of diffuse plaques in the aged canine brain. Neurobiol Aging 27:293-305. (Pubitemid 43038554)
    • (2006) Neurobiology of Aging , vol.27 , Issue.2 , pp. 293-305
    • Czasch, S.1    Paul, S.2    Baumgartner, W.3
  • 10
    • 70349579710 scopus 로고    scopus 로고
    • Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis
    • Deb C, Lafrance-Corey RG, Zoecklein L, Papke L, Rodriguez M, Howe CL (2009) Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis. J Neuropathol Exp Neurol 68:1037-1048.
    • (2009) J Neuropathol Exp Neurol , vol.68 , pp. 1037-1048
    • Deb, C.1    Lafrance-Corey, R.G.2    Zoecklein, L.3    Papke, L.4    Rodriguez, M.5    Howe, C.L.6
  • 13
    • 0031002545 scopus 로고    scopus 로고
    • Axonal damage in acute multiple sclerosis lesions
    • DOI 10.1093/brain/120.3.393
    • Ferguson B, Matyszak MK, Esiri MM, Perry VH (1997) Axonal damage in acute multiple sclerosis lesions. Brain 120(Pt 3):393-399. (Pubitemid 27153632)
    • (1997) Brain , vol.120 , Issue.3 , pp. 393-399
    • Ferguson, B.1    Matyszak, M.K.2    Esiri, M.M.3    Perry, V.H.4
  • 14
    • 0029384188 scopus 로고
    • Amyloid precursor protein (APP) expression in multiple sclerosis lesions
    • Gehrmann J, Banati RB, Cuzner ML, Kreutzberg GW, Newcombe J (1995) Amyloid precursor protein (APP) expression in multiple sclerosis lesions. Glia 15:141-151.
    • (1995) Glia , vol.15 , pp. 141-151
    • Gehrmann, J.1    Banati, R.B.2    Cuzner, M.L.3    Kreutzberg, G.W.4    Newcombe, J.5
  • 15
    • 0027482350 scopus 로고
    • Beta-Amyloid precursor protein (beta APP) as a marker for axonal injury after head injury
    • DOI 10.1016/0304-3940(93)90398-5
    • Gentleman SM, Nash MJ, Sweeting CJ, Graham DI, Roberts GW (1993) Beta-amyloid precursor protein (beta APP) as a marker for axonal injury after head injury. Neurosci Lett 160:139-144. (Pubitemid 23294725)
    • (1993) Neuroscience Letters , vol.160 , Issue.2 , pp. 139-144
    • Gentleman, S.M.1    Nash, M.J.2    Sweeting, C.J.3    Graham, D.I.4    Roberts, G.W.5
  • 16
    • 77954617977 scopus 로고    scopus 로고
    • Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons
    • Gilley J, Coleman MP (2010) Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons. PLoS Biol 8:e1000300.
    • (2010) PLoS Biol , vol.8
    • Gilley, J.1    Coleman, M.P.2
  • 17
    • 0034438296 scopus 로고    scopus 로고
    • Neurofilaments in health and disease
    • Gotow T (2000) Neurofilaments in health and disease. Med Electron Microsc 33:173-199.
    • (2000) Med Electron Microsc , vol.33 , pp. 173-199
    • Gotow, T.1
  • 18
    • 84862505128 scopus 로고    scopus 로고
    • Mild transcriptional changes of extracellular matrix but extensive matrix accumulation in a distinct spatio-temporal pattern within chronic demyelinated spinal cord lesions in Theiler's murine encephalomyelitis
    • doi:10.1111/j.1750-3639.2011.00518.x
    • Haist VUR, Kalkuhl A, Deschl U, Baumgärtner W (2011) Mild transcriptional changes of extracellular matrix but extensive matrix accumulation in a distinct spatio-temporal pattern within chronic demyelinated spinal cord lesions in Theiler's murine encephalomyelitis. Brain Pathol doi:10.1111/j.1750-3639.2011.00518.x.
    • (2011) Brain Pathol
    • Haist, V.U.R.1    Kalkuhl, A.2    Deschl, U.3    Baumgärtner, W.4
  • 19
    • 34447637424 scopus 로고    scopus 로고
    • CD8+ T cells directed against a viral peptide contribute to loss of motor function by disrupting axonal transport in a viral model of fulminant demyelination
    • DOI 10.1016/j.jneuroim.2007.04.005, PII S0165572807001245
    • Howe CL, Ure D, Adelson JD, LaFrance-Corey R, Johnson A, Rodriguez M (2007) CD8+ T cells directed against a viral peptide contribute to loss of motor function by disrupting axonal transport in a viral model of fulminant demyelination. J Neuroimmunol 188:13-21. (Pubitemid 47095011)
    • (2007) Journal of Neuroimmunology , vol.188 , Issue.1-2 , pp. 13-21
    • Howe, C.L.1    Ure, D.2    Adelson, J.D.3    LaFrance-Corey, R.4    Johnson, A.5    Rodriguez, M.6
  • 20
    • 0035818998 scopus 로고    scopus 로고
    • Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP
    • DOI 10.1038/414643a
    • Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS (2001) Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature 414:643-648. (Pubitemid 33151260)
    • (2001) Nature , vol.414 , Issue.6864 , pp. 643-648
    • Kamal, A.1    Almenar-Queralt, A.2    LeBlanc, J.F.3    Roberts, E.A.4    Goldstein, L.S.B.5
  • 21
    • 31044441703 scopus 로고    scopus 로고
    • Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways
    • DOI 10.1016/j.bcp.2005.11.019, PII S0006295205007835
    • Knowles HJ, te Poele RH, Workman P, Harris AL (2006) Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways. Biochem Pharmacol 71:646-656. (Pubitemid 43121998)
    • (2006) Biochemical Pharmacology , vol.71 , Issue.5 , pp. 646-656
    • Knowles, H.J.1    Poole, R.T.2    Workman, P.3    Harris, A.L.4
  • 22
    • 54049118799 scopus 로고    scopus 로고
    • Insights into post-translational processing of beta-galactosidase in an animal model resembling late infantile human G-gangliosidosis
    • Kreutzer R, Kreutzer M, Propsting MJ, Sewell AC, Leeb T, Naim HY, Baumgartner W (2008) Insights into post-translational processing of beta-galactosidase in an animal model resembling late infantile human G-gangliosidosis. J Cell Mol Med 12:1661-1671.
    • (2008) J Cell Mol Med , vol.12 , pp. 1661-1671
    • Kreutzer, R.1    Kreutzer, M.2    Propsting, M.J.3    Sewell, A.C.4    Leeb, T.5    Naim, H.Y.6    Baumgartner, W.7
  • 23
    • 67549111912 scopus 로고    scopus 로고
    • Generation and characterization of a polyclonal antibody for the detection of Theiler's murine encephalomyelitis virus by light and electron microscopy
    • Kummerfeld M, Meens J, Haas L, Baumgartner W, Beineke A (2009) Generation and characterization of a polyclonal antibody for the detection of Theiler's murine encephalomyelitis virus by light and electron microscopy. JVirol Methods 160:185-188.
    • (2009) JVirol Methods , vol.160 , pp. 185-188
    • Kummerfeld, M.1    Meens, J.2    Haas, L.3    Baumgartner, W.4    Beineke, A.5
  • 24
    • 0023520075 scopus 로고
    • Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their existence in the normal nervous system of adult rats
    • Lee VM, Carden MJ, Schlaepfer WW, Trojanowski JQ (1987) Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their existence in the normal nervous system of adult rats. J Neurosci 7:3474-3488. (Pubitemid 18000675)
    • (1987) Journal of Neuroscience , vol.7 , Issue.11 , pp. 3474-3488
    • Lee, V.M.-Y.1    Carden, M.J.2    Schlaepfer, W.W.3    Trojanowski, J.Q.4
  • 25
    • 0027087170 scopus 로고
    • Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34(cdc2)
    • Lew J, Winkfein RJ, Paudel HK, Wang JH (1992) Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2. J Biol Chem 267:25922-25926. (Pubitemid 23013996)
    • (1992) Journal of Biological Chemistry , vol.267 , Issue.36 , pp. 25922-25926
    • Lew, J.1    Winkfein, R.J.2    Paudel, H.K.3    Wang, J.H.4
  • 26
    • 79959499097 scopus 로고    scopus 로고
    • The balance of pro-inflammatory and trophic factors in multiple sclerosis patients: Effects of acute relapse and immunomodulatory treatment
    • Lindquist S, Hassinger S, Lindquist JA, Sailer M (2011) The balance of pro-inflammatory and trophic factors in multiple sclerosis patients: effects of acute relapse and immunomodulatory treatment. Mult Scler 17:851-866.
    • (2011) Mult Scler , vol.17 , pp. 851-866
    • Lindquist, S.1    Hassinger, S.2    Lindquist, J.A.3    Sailer, M.4
  • 28
    • 0033778845 scopus 로고    scopus 로고
    • Accumulation of phosphorylated neurofilaments and increase in apoptosis-specific protein and phosphorylated c-Jun induced by proteasome inhibitors
    • Masaki R, Saito T, Yamada K, Ohtani-Kaneko R (2000) Accumulation of phosphorylated neurofilaments and increase in apoptosis-specific protein and phosphorylated c-Jun induced by proteasome inhibitors. J Neurosci Res 62:75-83.
    • (2000) J Neurosci Res , vol.62 , pp. 75-83
    • Masaki, R.1    Saito, T.2    Yamada, K.3    Ohtani-Kaneko, R.4
  • 29
    • 0033571378 scopus 로고    scopus 로고
    • Quantitation of spinal cord demyelination, remyelination, atrophy, and axonal loss in a model of progressive neurologic injury
    • DOI 10.1002/(SICI)1097-4547(19991115)58:4<492::AID-JNR3>3.0.CO;2-P
    • McGavern DB, Murray PD, Rodriguez M (1999) Quantitation of spinal cord demyelination, remyelination, atrophy, and axonal loss in a model of progressive neurologic injury. J Neurosci Res 58:492-504. (Pubitemid 29530433)
    • (1999) Journal of Neuroscience Research , vol.58 , Issue.4 , pp. 492-504
    • McGavern, D.B.1    Murray, P.D.2    Rodriguez, M.3
  • 30
    • 63649153518 scopus 로고    scopus 로고
    • A dual leucine kinase-dependent axon self-destruction program promotesWallerian degeneration
    • Miller BR, Press C, Daniels RW, Sasaki Y, Milbrandt J, DiAntonio A (2009) A dual leucine kinase-dependent axon self-destruction program promotesWallerian degeneration. Nat Neurosci 12:387-389.
    • (2009) Nat Neurosci , vol.12 , pp. 387-389
    • Miller, B.R.1    Press, C.2    Daniels, R.W.3    Sasaki, Y.4    Milbrandt, J.5    DiAntonio, A.6
  • 31
    • 33646257802 scopus 로고    scopus 로고
    • Dynein mediates retrograde neurofilament transport within axons and anterograde delivery of NFs from perikarya into axons: Regulation by multiple phosphorylation events
    • Motil J, Chan WK, Dubey M, Chaudhury P, Pimenta A, Chylinski TM et al (2006) Dynein mediates retrograde neurofilament transport within axons and anterograde delivery of NFs from perikarya into axons: regulation by multiple phosphorylation events. Cell Motil Cytoskeleton 63:266-286.
    • (2006) Cell Motil Cytoskeleton , vol.63 , pp. 266-286
    • Motil, J.1    Chan, W.K.2    Dubey, M.3    Chaudhury, P.4    Pimenta, A.5    Chylinski, T.M.6
  • 32
    • 0031821271 scopus 로고    scopus 로고
    • + T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis
    • Murray PD, Pavelko KD, Leibowitz J, Lin X, Rodriguez M (1998) CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis. JVirol 72:7320-7329. (Pubitemid 28377863)
    • (1998) Journal of Virology , vol.72 , Issue.9 , pp. 7320-7329
    • Murray, P.D.1    Pavelko, K.D.2    Leibowitz, J.3    Lin, X.4    Rodriguez, M.5
  • 33
    • 60549089207 scopus 로고    scopus 로고
    • APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
    • Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M (2009) APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457:981-989.
    • (2009) Nature , vol.457 , pp. 981-989
    • Nikolaev, A.1    McLaughlin, T.2    O'Leary, D.D.3    Tessier-Lavigne, M.4
  • 35
    • 62149128630 scopus 로고    scopus 로고
    • The importance of NAD in multiple sclerosis
    • Penberthy WT, Tsunoda I (2009) The importance of NAD in multiple sclerosis. Curr Pharm Des 15:64-99.
    • (2009) Curr Pharm des , vol.15 , pp. 64-99
    • Penberthy, W.T.1    Tsunoda, I.2
  • 36
    • 53749093269 scopus 로고    scopus 로고
    • Review of the multiple aspects of neurofilament functions, and their possible contribution to neurodegeneration
    • Perrot R, Berges R, Bocquet A, Eyer J (2008) Review of the multiple aspects of neurofilament functions, and their possible contribution to neurodegeneration. Mol Neurobiol 38:27-65.
    • (2008) Mol Neurobiol , vol.38 , pp. 27-65
    • Perrot, R.1    Berges, R.2    Bocquet, A.3    Eyer, J.4
  • 37
    • 77950352612 scopus 로고    scopus 로고
    • Theiler's murine encephalomyelitis virus preferentially infects immature stages of the murine oligodendrocyte precursor cell line BO-1 and blocks oligodendrocytic differentiation in vitro
    • Pringproa K, Rohn K, Kummerfeld M, Wewetzer K, Baumgartner W (2010) Theiler's murine encephalomyelitis virus preferentially infects immature stages of the murine oligodendrocyte precursor cell line BO-1 and blocks oligodendrocytic differentiation in vitro. Brain Res 1327:24-37.
    • (2010) Brain Res , vol.1327 , pp. 24-37
    • Pringproa, K.1    Rohn, K.2    Kummerfeld, M.3    Wewetzer, K.4    Baumgartner, W.5
  • 38
    • 77950366745 scopus 로고    scopus 로고
    • PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta
    • Qian W, Shi J, Yin X, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F (2010) PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. J Alzheimers Dis 19:1221-1229.
    • (2010) J Alzheimers Dis , vol.19 , pp. 1221-1229
    • Qian, W.1    Shi, J.2    Yin, X.3    Iqbal, K.4    Grundke-Iqbal, I.5    Gong, C.X.6    Liu, F.7
  • 39
    • 33847326671 scopus 로고    scopus 로고
    • The role of myelin in Theiler's virus persistence in the central nervous system
    • Roussarie JP, Ruffie C, Brahic M (2007) The role of myelin in Theiler's virus persistence in the central nervous system. PLoS Pathog 3:e23.
    • (2007) PLoS Pathog , vol.3
    • Roussarie, J.P.1    Ruffie, C.2    Brahic, M.3
  • 40
    • 84862488894 scopus 로고    scopus 로고
    • Animal model for multiple sclerosis
    • A Minagar (ed.), Elsevier Books: Burlington, MA
    • Sato F, Omura S, Martinez NE, Tsunoda I (2011) Animal model for multiple sclerosis. In: Neuroinflammation, A Minagar (ed.), pp. 55-79. Elsevier Books: Burlington, MA.
    • (2011) Neuroinflammation , pp. 55-79
    • Sato, F.1    Omura, S.2    Martinez, N.E.3    Tsunoda, I.4
  • 41
    • 79958838939 scopus 로고    scopus 로고
    • Axonal loss and neurofilament phosphorylation changes accompany lesion development and clinical progression in multiple sclerosis
    • Schirmer L, Antel JP, Bruck W, Stadelmann C (2011) Axonal loss and neurofilament phosphorylation changes accompany lesion development and clinical progression in multiple sclerosis. Brain Pathol 21:428-440.
    • (2011) Brain Pathol , vol.21 , pp. 428-440
    • Schirmer, L.1    Antel, J.P.2    Bruck, W.3    Stadelmann, C.4
  • 42
    • 0022300365 scopus 로고
    • Mechanisms underlying the neuronal response to ischemic injury. Calcium-activated proteolysis of neurofilaments
    • Schlaepfer WW, Zimmerman UJ (1985) Mechanisms underlying the neuronal response to ischemic injury. Calcium-activated proteolysis of neurofilaments. Prog Brain Res 63:185-196.
    • (1985) Prog Brain Res , vol.63 , pp. 185-196
    • Schlaepfer, W.W.1    Zimmerman, U.J.2
  • 43
    • 77950824570 scopus 로고    scopus 로고
    • Axonal pathology and loss precede demyelination and accompany chronic lesions in a spontaneously occurring animal model of multiple sclerosis
    • Seehusen F, Baumgartner W (2010) Axonal pathology and loss precede demyelination and accompany chronic lesions in a spontaneously occurring animal model of multiple sclerosis. Brain Pathol 20:551-559.
    • (2010) Brain Pathol , vol.20 , pp. 551-559
    • Seehusen, F.1    Baumgartner, W.2
  • 45
    • 0033783031 scopus 로고    scopus 로고
    • Bidirectional translocation of neurofilaments along microtubules mediated in part by dynein/dynactin
    • Shah JV, Flanagan LA, Janmey PA, Leterrier JF (2000) Bidirectional translocation of neurofilaments along microtubules mediated in part by dynein/dynactin. Mol Biol Cell 11:3495-3508.
    • (2000) Mol Biol Cell , vol.11 , pp. 3495-3508
    • Shah, J.V.1    Flanagan, L.A.2    Janmey, P.A.3    Leterrier, J.F.4
  • 46
    • 42049107093 scopus 로고    scopus 로고
    • Regulation of neurofilament dynamics by phosphorylation
    • DOI 10.1111/j.1460-9568.2008.06165.x
    • Shea TB, Chan WK (2008) Regulation of neurofilament dynamics by phosphorylation. Eur J Neurosci 27:1893-1901. (Pubitemid 351521484)
    • (2008) European Journal of Neuroscience , vol.27 , Issue.8 , pp. 1893-1901
    • Shea, T.B.1    Chan, W.K.-H.2
  • 47
    • 70349232336 scopus 로고    scopus 로고
    • Collateral bystander damage by myelin-directed CD8+ T cells causes axonal loss
    • Sobottka B, Harrer MD, Ziegler U, Fischer K, Wiendl H, Hunig T et al (2009) Collateral bystander damage by myelin-directed CD8+ T cells causes axonal loss. Am J Pathol 175:1160-1166.
    • (2009) Am J Pathol , vol.175 , pp. 1160-1166
    • Sobottka, B.1    Harrer, M.D.2    Ziegler, U.3    Fischer, K.4    Wiendl, H.5    Hunig, T.6
  • 48
    • 72449132320 scopus 로고    scopus 로고
    • Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis
    • Soulika AM, Lee E, McCauley E, Miers L, Bannerman P, Pleasure D (2009) Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis. J Neurosci 29:14965-14979.
    • (2009) J Neurosci , vol.29 , pp. 14965-14979
    • Soulika, A.M.1    Lee, E.2    McCauley, E.3    Miers, L.4    Bannerman, P.5    Pleasure, D.6
  • 49
    • 0030684714 scopus 로고    scopus 로고
    • Protein serine/threonine phosphatase 1 and 2A associate with and dephosphorylate neurofilaments
    • DOI 10.1016/S0169-328X(97)00117-4, PII S0169328X97001174
    • Strack S, Westphal RS, Colbran RJ, Ebner FF, Wadzinski BE (1997) Protein serine/threonine phosphatase 1 and 2A associate with and dephosphorylate neurofilaments. Brain Res Mol Brain Res 49: 15-28. (Pubitemid 27453110)
    • (1997) Molecular Brain Research , vol.49 , Issue.1-2 , pp. 15-28
    • Strack, S.1    Westphal, R.S.2    Colbran, R.J.3    Ebner, F.F.4    Wadzinski, B.E.5
  • 51
    • 62249199672 scopus 로고    scopus 로고
    • Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection
    • Tsunoda I (2008) Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection. FutureVirol 3:579-593.
    • (2008) FutureVirol , vol.3 , pp. 579-593
    • Tsunoda, I.1
  • 53
    • 36349002847 scopus 로고    scopus 로고
    • Targeting inflammatory demyelinating lesions to sites of wallerian degeneration
    • DOI 10.2353/ajpath.2007.070147
    • Tsunoda I, Tanaka T, Saijoh Y, Fujinami RS (2007) Targeting inflammatory demyelinating lesions to sites of Wallerian degeneration. Am J Pathol 171:1563-1575. (Pubitemid 350158317)
    • (2007) American Journal of Pathology , vol.171 , Issue.5 , pp. 1563-1575
    • Tsunoda, I.1    Tanaka, T.2    Saijoh, Y.3    Fujinami, R.S.4
  • 54
    • 33847084438 scopus 로고    scopus 로고
    • Contrasting roles for axonal degeneration in an autoimmune versus viral model of multiple sclerosis: When can axonal injury be beneficial?
    • DOI 10.2353/ajpath.2007.060683
    • Tsunoda I, Tanaka T, Terry EJ, Fujinami RS (2007) Contrasting roles for axonal degeneration in an autoimmune versus viral model of multiple sclerosis: when can axonal injury be beneficial? Am J Pathol 170:214-226. (Pubitemid 47339201)
    • (2007) American Journal of Pathology , vol.170 , Issue.1 , pp. 214-226
    • Tsunoda, I.1    Tanaka, T.2    Terry, E.J.3    Fujinami, R.S.4
  • 55
    • 56549124821 scopus 로고    scopus 로고
    • Limited remyelination in Theiler's murine encephalomyelitis due to insufficient oligodendroglial differentiation of nerve/glial antigen 2 (NG2)-positive putative oligodendroglial progenitor cells
    • Ulrich R, Seeliger F, Kreutzer M, Germann PG, Baumgartner W (2008) Limited remyelination in Theiler's murine encephalomyelitis due to insufficient oligodendroglial differentiation of nerve/glial antigen 2 (NG2)-positive putative oligodendroglial progenitor cells. Neuropathol Appl Neurobiol 34:603-620.
    • (2008) Neuropathol Appl Neurobiol , vol.34 , pp. 603-620
    • Ulrich, R.1    Seeliger, F.2    Kreutzer, M.3    Germann, P.G.4    Baumgartner, W.5
  • 56
    • 77952110729 scopus 로고    scopus 로고
    • Machine learning approach identifies new pathways associated with demyelination in a viral model of multiple sclerosis
    • Ulrich R, Kalkuhl A, Deschl U, Baumgartner W (2010) Machine learning approach identifies new pathways associated with demyelination in a viral model of multiple sclerosis. J Cell Mol Med 14:434-448.
    • (2010) J Cell Mol Med , vol.14 , pp. 434-448
    • Ulrich, R.1    Kalkuhl, A.2    Deschl, U.3    Baumgartner, W.4
  • 57
    • 0033892876 scopus 로고    scopus 로고
    • Extensive injury of descending neurons demonstrated by retrograde labeling in a virus-induced murine model of chronic inflammatory demyelination
    • Ure D, Rodriguez M (2000) Extensive injury of descending neurons demonstrated by retrograde labeling in a virus-induced murine model of chronic inflammatory demyelination. J Neuropathol Exp Neurol 59:664-678. (Pubitemid 30626737)
    • (2000) Journal of Neuropathology and Experimental Neurology , vol.59 , Issue.8 , pp. 664-678
    • Ure, D.1    Rodriguez, M.2
  • 58
    • 0029022205 scopus 로고
    • Neuronal cyclin-dependent kinase-5 phosphorylation sites in neurofilament protein (NF-H) are dephosphorylated by protein phosphatase 2A
    • Veeranna SKT, Link WT, Jaffe H, Wang J, Pant HC (1995) Neuronal cyclin-dependent kinase-5 phosphorylation sites in neurofilament protein (NF-H) are dephosphorylated by protein phosphatase 2A. J Neurochem 64:2681-2690.
    • (1995) J Neurochem , vol.64 , pp. 2681-2690
    • Veeranna, S.K.T.1    Link, W.T.2    Jaffe, H.3    Wang, J.4    Pant, H.C.5
  • 59
    • 77958026084 scopus 로고    scopus 로고
    • Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway
    • Vohra BP, Sasaki Y, Miller BR, Chang J, DiAntonio A, Milbrandt J (2010) Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway. J Neurosci 30:13729-13738.
    • (2010) J Neurosci , vol.30 , pp. 13729-13738
    • Vohra, B.P.1    Sasaki, Y.2    Miller, B.R.3    Chang, J.4    DiAntonio, A.5    Milbrandt, J.6
  • 62
    • 0032694199 scopus 로고    scopus 로고
    • Kinesin-mediated transport of neurofilament protein oligomers in growing axons
    • Yabe JT, Pimenta A, Shea TB (1999) Kinesin-mediated transport of neurofilament protein oligomers in growing axons. J Cell Sci 112:3799-3814.
    • (1999) J Cell Sci , vol.112 , pp. 3799-3814
    • Yabe, J.T.1    Pimenta, A.2    Shea, T.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.