CD8+ T cells directed against a viral peptide contribute to loss of motor function by disrupting axonal transport in a viral model of fulminant demyelination

Journal of Neuroimmunology

Volumn 188, Issue 1-2, 2007, Pages 13-21

  Howe, Charles L ^a,b   Ure, Daren ^a   Adelson, Jaimie D ^c   LaFrance Corey, Reghann ^b   Johnson, Aaron ^a   Rodriguez, Moses ^a,b  

^a MAYO GRADUATE SCHOOL   (United States)

^b Mayo Clinic   (United States)

^c MAYO CLINIC   (United States)

Author keywords

Axon injury; Cytotoxic T cells; Interferon gamma; MHC Class I; Multiple sclerosis; Retrograde transport

Indexed keywords

GAMMA INTERFERON RECEPTOR; PHENYLALANYLHISTIDYLALANYLGLYCYLSERYLLEUCYLLEUCYLVALYLPHENYLALANYL METHIONINE; PROTEIN VP2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXONAL INJURY; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DEMYELINATION; DISEASE PREDISPOSITION; ENCEPHALOMYELITIS; IMMUNE MEDIATED INJURY; MOTOR PERFORMANCE; MOUSE; MOUSE STRAIN; MULTIPLE SCLEROSIS; MURINE ENCEPHALOMYELITIS VIRUS; NERVE DEGENERATION; NERVE FIBER TRANSPORT; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD;

ANALYSIS OF VARIANCE; ANIMALS; AXONAL TRANSPORT; AXONS; BEHAVIOR, ANIMAL; CAPSID PROTEINS; CARDIOVIRUS INFECTIONS; CD8-POSITIVE T-LYMPHOCYTES; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; MICE; MICE, KNOCKOUT; MOTOR ACTIVITY; RECEPTORS, INTERFERON; ROTAROD PERFORMANCE TEST; SILVER STAINING;

EID: 34447637424     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2007.04.005     Document Type: Article

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