STAT3 genotypic variation and cellular STAT3 activation and colon leukocyte recruitment in pediatric crohn disease

Journal of Pediatric Gastroenterology and Nutrition

Volumn 55, Issue 1, 2012, Pages 32-43

  Willson, Tara A ^a   Kuhn, Benjamin R ^a   Jurickova, Ingrid ^a   Gerad, Shaina ^a   Moon, David ^a   Bonkowski, Erin ^a   Carey, Rebecca ^a   Collins, Margaret H ^b   Xu, Huan ^c   Jegga, Anil G ^c   Guthery, Stephen L ^a   Denson, Lee A ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

CXCR2; neutrophil recruitment; pediatric Crohn disease; signal transducer and activator of transcription 3

Indexed keywords

CHEMOKINE RECEPTOR CXCR2; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; JANUS KINASE 2; STAT3 PROTEIN;

ADOLESCENT; ADULT; ALLELE; ARTICLE; CD4+ T LYMPHOCYTE; CHILD; CHROMOSOME 4Q; CLINICAL ARTICLE; CORRELATION ANALYSIS; CROHN DISEASE; CXCL1 CHEMOKINE GENE; CXCL3 CHEMOKINE GENE; FEMALE; FLOW CYTOMETRY; GENE; GENE EXPRESSION; GENE FUNCTION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; GRANULOCYTE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTERLEUKIN 8 GENE; LEUKOCYTE; MALE; NEUTROPHIL; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; S100A12 GENE; S100A8 GENE; S100A9 GENE; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; SOCS3 GENE; STAT3 GENE; UPREGULATION;

ADOLESCENT; ALLELES; B-LYMPHOCYTES; CALGRANULIN A; CALGRANULIN B; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CHEMOKINE CXCL1; CHEMOKINES, CXC; CHILD; COLON; CROHN DISEASE; FEMALE; GENE EXPRESSION; GENETIC VARIATION; GENOTYPE; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; INTERLEUKIN-8; JANUS KINASE 2; LYMPHOCYTE COUNT; MALE; NEUTROPHILS; PHOSPHORYLATION; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN-8B; S100 PROTEINS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TYROSINE; UP-REGULATION;

HUMAN HERPESVIRUS 4;

EID: 84862333915     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0b013e318246be78     Document Type: Article

References (35)

1. Barrett JC, Hansoul S, Nicolae DL, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008;40:955-62.
2. Imielinski M, Baldassano RN, Griffiths A, et al. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet 2009;41:1335-40.
3. Mathew CG. New links to the pathogenesis of Crohn disease provided by genome-wide association scans. Nat Rev Genet 2008;9:9-14.
4. Rossin EJ, Lage K, Raychaudhuri S, et al. Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology. PLoS Genet 2011;7: e1001273.
5. Grivennikov S, Karin E, Terzic J, et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitisassociated cancer. Cancer Cell 2009;15:103-13.
6. Bollrath J, Phesse TJ, von Burstin VA, et al. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell 2009;15:91-102.
7. Takeda K, Clausen BE, Kaisho T, et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 1999;10:39-49.
8. Atreya R, Mudter J, Finotto S, et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: eviDence in crohn disease and experimental colitis in vivo. Nat Med 2000;6:583-8.
9. Chaudhry A, Rudra D, Treuting P, et al. CD4pregulatory T cells control TH17 responses in a Stat3-depenDent manner. Science 2009;326: 986-91.
10. Nguyen-Jackson H, Panopoulos AD, Zhang H, et al. STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction. Blood 2010;115:3354-63.
11. Carey R, Jurickova I, Ballard E, et al. Activation of an IL-6:STAT3-depenDent transcriptome in pediatric-onset inflammatory bowel disease. Inflamm Bowel Dis 2008;14:446-57.
12. Hyams JS, Ferry GD, Mandel FS, et al. Development and validation of a pediatric Crohn's disease activity index. J Pediatr Gastroenterol Nutr 1991;12:439-47.
13. D'Haens GR, Geboes K, Peeters M, et al. Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum. Gastroenterology 1998;114:262-7.
14. Satsangi J, Silverberg MS, Vermeire S, et al. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut 2006;55:749-53.
15. Han X, Uchida K, Jurickova I, et al. Granulocyte-macrophage colonystimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease. Gastroenterology 2009;136:1261-71. e1-3.
16. Leach ST, Yang Z, Messina I, et al. Serum and mucosal S100 proteins, calprotectin (S100A8/S100A9) and S100A12, are elevated at diagnosis in children with inflammatory bowel disease. Scand J Gastroenterol 2007;42:1321-31.
17. Krutzik PO, Clutter MR, Nolan GP. Coordinate analysis of murine immune cell surface markers and intracellular phosphoproteins by flow cytometry. J Immunol 2005;175:2357-65.
18. Cheng PY, Corzo CA, Luetteke N, et al. Inhibition of Dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med 2008;205:2235-49.
19. Kaiser T, Langhorst J, Wittkowski H, et al. Faecal S100A12 as a noninvasive marker distinguishing inflammatory bowel disease from irritable bowel syndrome. Gut 2007;56:1706-13.
20. Foell D, Wittkowski H, Ren Z, et al. Phagocyte-specific S100 proteins are released from affected mucosa and promote immune responses during inflammatory bowel disease. J Pathol 2008;216:183-92.
21. Imada A, Ina K, Shimada M, et al. Coordinate upregulation of interleukin-8 and growth-related gene product-alpha is present in the colonic mucosa of inflammatory bowel. Scand J Gastroenterol 2001; 36:854-64.
22. Mazzucchelli L, Hauser C, Zgraggen K, et al. Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation. Am J Pathol 1994;144:997-1007.
23. Wuyts A,Van Osselaer N, Haelens A, et al. Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties. Biochemistry 1997;36:2716-23.
24. Williams EJ, Haque S, Banks C, et al. Distribution of the interleukin-8 receptors, CXCR1 and CXCR2, in inflamed gut tissue. J Pathol 2000; 192:533-9.
25. Bento AF, Leite DF, Claudino RF, et al. The selective nonpeptide CXCR2 antagonist SB225002 ameliorates acute experimental colitis in mice. J Leukoc Biol 2008;84:1213-21.
26. Farooq SM, Stillie R, Svensson M, et al. Therapeutic effect of blocking CXCR2 on neutrophil recruitment and dextran sodium sulfate-induced colitis. J Pharmacol Exp Ther 2009;329:123-9.
27. Ferguson LR, Han DY, Fraser AG, et al. Genetic factors in chronic inflammation: single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population. Mutat Res 2010;690:108-15.
28. Sandborn WJ, Ghosh S, Panes J, et al. Phase 2 study of CP-690,550, an oral Janus kinase inhibitor, in active ulcerative colitis. Gastroenterology 2011;140:S-110.
29. Sandborn WJ, Ghosh S, Panes J, et al. Phase 2 randomized study of CP-690,550, an oral Janus kinase inhibitor, in active Crohn's disease. Gastroenterology 2011;140:S-124.
30. Ghoreschi K, Laurence A, O'Shea JJ. Janus kinases in immune cell signaling. Immunol Rev 2009;228:273-87.
31. Chrencik JE, Patny A, Leung IK, et al. Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6. J Mol Biol 2010;400:413-33.
32. Sugimoto K. Role of STAT3 in inflammatory bowel disease. World J Gastroenterol 2008;14:5110-4.
33. Tebbutt NC, Giraud AS, Inglese M, et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med 2002;8: 1089-97.
34. Judd LM, Bredin K, Kalantzis A, et al. STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis. Gastroenterology 2006;131:1073-85.
35. Alonzi T, Newton IP, Bryce PJ, et al. Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis. Cytokine 2004;26:45-56.