Induction of an adaptive response in human blood lymphocytes exposed to radiofrequency fields: Influence of the universal mobile telecommunication system (UMTS) signal and the specific absorption rate

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 747, Issue 1, 2012, Pages 29-35

  Zeni, Olga ^a   Sannino, Anna ^a,b   Romeo, Stefania ^a,c   Massa, Rita ^a,d   Sarti, Maurizio ^a   Reddy, Abishek B ^e   Prihoda, Thomas J ^f   Vijayalaxmi, ^e   Scarfì, Maria Rosaria ^a  

^a CNR   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^f University of Texas Health Science Center   (United States)

Author keywords

Adaptive response; Human blood lymphocytes; Micronuclei; Radiofrequency fields; Specific absorption rate; UMTS signal

Indexed keywords

MITOMYCIN C; PHYTOHEMAGGLUTININ;

ABSORPTION; ADAPTATION; ARTICLE; CELL PROLIFERATION; CYTOKINESIS; DOSIMETRY; ELECTROMAGNETIC FIELD; EXPOSURE; GENOTOXICITY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LYMPHOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; RADIOFREQUENCY; TELECOMMUNICATION; UNIVERSAL MOBILE TELECOMMUNICATION SYSTEM;

ADAPTATION, PHYSIOLOGICAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; LYMPHOCYTES; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MITOMYCIN; RADIATION TOLERANCE; RADIO WAVES;

EID: 84862306527     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2012.03.013     Document Type: Article

References (58)

1. Samson L., Cairns J. A new pathway for DNA repair in Escherichia coli. Nature 1977, 267:281-283.
2. Olivieri G., Bodycote J., Wolff S. Adaptive response of human lymphocytes to low concentrations of radioactive thymidine. Science 1984, 223:594-597.
3. Sanderson B.J.S., Morley A.A. Exposure of human lymphocytes to ionizing radiation reduces mutagenesis by subsequent ionizing radiation. Mutat. Res. 1986, 164:347-351.
4. Wiencke J.K., Afzal V., Olivieri G., Wolff S. Evidence that the [3H]thymidine-induced adaptive response in human lymphocytes to subsequent doses of X-rays involves the induction of a chromosomal repair mechanism. Mutagenesis 1986, 1:375-380.
5. Shadley J.D., Wolff S. Very low doses of X-rays can cause human lymphocytes to become less susceptible to ionizing radiation. Mutagenesis 1987, 2:95-96.
6. Shadley J.D., Afzal V., Wolff S. Characterization of the adaptive response to ionizing radiation induced by low doses of X-rays to human lymphocytes. Radiat. Res. 1987, 111:511-517.
7. Sankaranarayanan K., von Duyn A., Loos M.J., Natarajan A.T. Adaptive response of human lymphocytes to low-level radiation from radioisotopes or X-rays. Mutat. Res. 1989, 211:7-12.
8. Vijayalaxmi, Burkart W. Resistance and cross-resistance to chromosome damage in human blood lymphocytes exposed to bleomycin. Mutat. Res. 1989, 211:1-5.
9. Cai L., Liu S.Z. Induction of cytogenetic adaptive response of somatic and germ cells in vivo and in vitro by low-dose X-irradiation. Int. J. Radiat. Biol. 1990, 58:187-194.
10. Wang Z.-Q., Saigusa S., Sasaki M.S. Adaptive response to chromosome damage in cultured human lymphocytes primed with low doses of X-rays. Mutat. Res. 1991, 246:179-186.
11. Osmak M., Horvat D. Chromosomal analysis of Chinese hamster V79 cells exposed to multiple γ-ray fractions: induction of adaptive response to mitomycin. Mutat. Res. 1992, 282:259-263.
12. Shadley J.D., Dai G. Cytogenetic and survival adaptive response in G1 phase human lymphocytes. Mutat. Res. 1992, 265:273-281.
13. Dominguez I., Panneerselvam N., Escalza P., Natarajan A.T., Cortes F. Adaptive response to radiation damage in human lymphocytes conditioned with hydrogen peroxide as measured by the cytokinesis-block micronucleus technique. Mutat. Res. 1993, 301:135-141.
14. Madrigal-Bujaidar E., Cassani M., Martinez S., Morales T. Adaptive response induced by mitomycin C measuring the frequency of SCEs in human lymphocyte cultures. Mutat. Res. 1994, 322:301-305.
15. Rigaud O., Laquerbe A., Moustachi E. DNA sequence analysis of HPRT mutants in human lymphoblastoid cells adapted to ionizing radiation. Radiat. Res. 1995, 144:181-189.
16. Sasaki M.S. On the kinetics of the radioadaptive response in cultured mouse cells. Int. J. Radiat. Biol. 1995, 68:281-291.
17. Wojcik A., Streffer C. Application of a multiple fixation regimen to study the adaptive response to ionizing radiation in lymphocytes of two human donors. Mutat. Res. 1995, 326:109-116.
18. Zhang L. Cytogenetic adaptive response induced by pre-exposure in human lymphocytes and marrow cells in mice. Mutat. Res. 1995, 334:33-37.
19. Belyaev I.Y., Spivak I.M., Kolman A., Harms-Ringdahl M. Relationship between radiation induced adaptive response in human fibroblasts and changes in chromatin conformation. Mutat. Res. 1996, 358:223-230.
20. Stecca C., Gerber G.B. Adaptive response to DNA-damaging agents: a review of potential mechanisms. Biochem. Pharmacol. 1998, 55:941-951.
21. Stoilov L.M., Mullenders L.H.F., Darroudi F., Natarajan A.T. Adaptive response to DNA and chromosomal damage induced by X-rays in human blood lymphocytes. Mutagenesis 2007, 22:117-122.
22. Li X., Tang S., Huang H., Yang L., Liu J., Zhuang Z. Induction of a cell-survival adaptive response in MRC-5 cells by hydroquinone. Mutat. Res. 2008, 652:180-185.
23. Vijayalaxmi, Burkart W. Effect of 3-aminobenzamide on chromosome damage in human blood lymphocytes adapted to bleomycin. Mutagenesis 1989, 4:187-189.
24. Youngblom J.H., Wiencke J.K., Wolff S. Inhibition of adaptive response of human lymphocytes to very low doses of ionizing radiation by protein synthesis inhibitor, cycloheximide. Mutat. Res. 1989, 227:257-261.
25. Bauchinger M., Schmid E., Braselmann H., Nahrstedt U. Absence of adaptive response to low-level irradiation from tritiated thymidine and X-rays in lymphocytes of two individuals examined in serial experiments. Mutat. Res. 1989, 227:103-107.
26. Bosi A., Olivieri G. Variability of the adaptive response to ionizing radiation in humans. Mutat. Res. 1989, 211:13-17.
27. Schmid E., Bauchinger M., Nahrstedt U. Adaptive response after X-irradiation of human lymphocytes?. Mutagenesis 1989, 4:87-89.
28. Hain J., Jaussi R., Burkat W. Lack of adaptive response to low doses of ionizing radiation in human lymphocytes from five different donors. Mutat. Res. 1992, 283:137-144.
29. Vijayalaxmi, Leal B.Z., Deahl T.S., Meltz M.L. Variability in adaptive response to low dose radiation in human blood lymphocytes: consistent results from chromosome aberrations and micronuclei. Mutat. Res. 1995, 348:45-50.
30. Krishnaja A.P., Sharma N.K. Variability in cytogenetic adaptive response of cultured human lymphocytes to mitomycin C, bleomycin, quinacrine dihydrochloride, Co60 γ-rays and hyperthermia. Mutagenesis 2008, 23:77-86.
31. Cao Y., Xu Q., Jin Z.-D., Zhou Z., Nie J., Tong J. Induction of adaptive response: pre-exposure of mice to 900MHz radiofrequency fields reduces hematopoietic damage caused by subsequent exposure to ionizing radiation. Int. J. Radiat. Biol. 2011, 87:720-728.
32. Mortazavi S.M.J., Mosleh-Shirazi M.A., Tavassoli A.R., Taheri M., Bagheri Z., Ghalandari R., Bonyadi S., Shafie M., Haghani M. A comparative study on the increased radioresistance to lethal doses of gamma rays after exposure to microwave radiation and oral intake of flaxseed oil. Iran. J. Radiat. Res. 2011, 9:9-14.
33. Sannino A., Sarti M., Reddy S.B., Prihoda T.J., Vijayalaxmi, Scarfì M.R. Induction of adaptive response in human blood lymphocytes exposed to radiofrequency radiation. Radiat. Res. 2009, 170:735-742.
34. Sannino A., Zeni O., Sarti M., Romeo S., Reddy S.B., Belisario A., Prihoda T.J., Vijayalaxmi, Scarfì M.R. Characterization of radiofrequency-induced adaptive response in human peripheral blood lymphocytes: cell cycle effects. Int. J. Radiat. Biol. 2011, 87:1-8.
35. Sannino A., Calabrese M.L., d'Ambrosio G., Massa R., Petraglia G., Mita P., Sarti M., Scarfì M.R. Evaluation of cytotoxic and genotoxic effects in human peripheral blood leukocytes following exposure to 1950MHz modulated signal. IEEE Trans. Plasma Sci. 2006, 34:1441-1448.
36. Calabrese M.L., d'Ambrosio G., Massa R., Petraglia G. A high-efficiency waveguide applicator for in vivo exposure of mammalian cells at 1.95GHz. IEEE Trans. Microwave Theory Tech. 2006, 54:2256-2264.
37. Brescia F., Sarti M., Massa R., Calabrese M.L., Sannino A., Scarfì M.R. Reactive oxygen species formation is not enhanced by exposure to UMTS 1950MHz radiation and co-exposure to ferrous ions in Jurkat cells. Bioelectromagnetics 2009, 30:525-535.
38. Pozar D.M. Microwave Engineering 2005, J. Wiley, New York. third ed.
39. Gabriel C., Gabriel S., Corthout E. The dielectric properties of biological tissues: I. literature survey. Phys. Med. Biol. 1996, 41:2231-2249.
40. Romeo S., Di Donato L., Bucci O.M., Catapano I., Crocco L., Scarfì M.R., Massa R. Dielectric characterization study of liquid-based materials for mimicking breast tissues. Microwave Opt. Tech. Lett. 2011, 53:1276-1280.
41. Fenech M. The in vitro micronucleus technique. Mutat. Res. 2000, 455:81-95.
42. Fenech M., Bonassi S., Turner J., Lando C., Ceppi M., Chang W.P., Holland N., Kirsch-Volders M., Zeiger E., Zijno A. Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project. Mutat. Res. 2003, 534:45-64.
43. Littell R.C., Milliken G.A., Stroup W.W., Wolfinger R.D., Schabenberger O.O. SAS for Mixed Models 2006, SAS Institute Inc., Cary, NC. 2nd ed.
44. Litovitz T.A., Penafiel L.M., Farrel J.M., Krause D., Meister R., Mullins J.M. Bioeffects induced by exposure to microwaves are mitigated by superposition of ELF noise. Bioelectromagnetics 1997, 18:422-430.
45. Belyaev I. Dependence of non-thermal biological effects of microwaves on physical and biological variables: implications for reproducibility and safety standards. Nonthermal Effects and Mechanisms of Interaction Between Electromagnetic Fields and Living Matter 2010, 187-218. ICEMS Monograph 5. http://www.icems.eu/papers.htm?f=/c/a/2009/12/15/MNHJ1B49KH.DTL, L. Giuliani, M. Soffritti (Eds.).
46. Brusick D., Albertini R., McRee D., Peterson D., Williams G., Hanawalt P., Preston J. Genotoxicity of radiofrequency radiation. DNA/genotox expert panel. Environ. Mol. Mutagen. 1998, 32:1-16.
47. Verschaeve L., Maes A. Genetic, carcinogenic and teratogenic effects of radiofrequency fields. Mutat. Res. 1998, 410:141-165.
48. Moulder J.E., Erdeiich L.S., Malyapa R.S., Merritt J., Pickard W.F., Vijayalaxmi Cell phones and cancer: what is the evidence for a connection?. Radiat. Res. 1999, 15:513-531.
49. Heynick L.N., Johnston S.A., Mason P.A. Radio frequency electromagnetic fields: cancer mutagenesis, and genotoxicity. Bioelectromagnetics 2003, 6:S74-S100.
50. Meltz M.L. Radiofrequency exposure and mammalian cell toxicity, genotoxicity, and transformation. Bioelectromagnetics 2003, 6:S196-S213.
51. Vijayalaxmi, Obe G. Controversial cytogenetic observations in mammalian somatic cells exposed to radiofrequency radiation. Radiat. Res. 2004, 162:481-496.
52. Verschaeve L. Genetic effects of radiofrequency radiation (RFR). Toxicol. Appl. Pharmacol. 2005, 207:S336-S341.
53. H. Lai, Evidence for genotoxic effects (RFR and ELF genotoxicity), Bioinitiative working group, Section 6 (2007) 1-43.
54. Vijayalaxmi, Prihoda T.J. Genetic damage in mammalian somatic cells exposed to radiofrequency radiation: a meta-analysis of data from 63 publications (1990-2005). Radiat. Res. 2008, 169:561-574.
55. Phillips J.L., Singh N.P., Lai H. Electromagnetic fields and DNA damage. Pathophysiology 2009, 16:79-88.
56. Ruediger H. Genotoxic effects of radiofrequency electromagnetic fields. Pathophysiology 2009, 16:89-102.
57. Verschaeve L., Juutilainen J., Lagroye I., Miyakoshi J., Saunders R., de Seze R., Tenforde T., van Rongen E., Veyret B., Xu Z. In vitro and in vivo genotoxicity of radiofrequency fields. Mutat. Res. 2010, 705:252-268.
58. Pakhomov A.G., Murphy M.B. Comprehensive review of the research on biological effects of pulsed radiofrequency radiation in Russia and the former Soviet Union. Advances in Electromagnetic Fields in Living System 2000, vol. 3:265-290. Academic/Plenum Publishers, New York.