Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: Synthesis and SAR studies

Journal of Medicinal Chemistry

Volumn 46, Issue 12, 2003, Pages 2482-2493

  Silvestri, Romano ^a   De Martino, Gabriella ^a   La Regina, Giuseppe ^a   Artico, Marino ^a   Massa, Silvio ^b   Vargiu, Laura ^c   Mura, Massimo ^c   Loi, Anna Giulia ^c   Marceddu, Tiziana ^c   La Colla, Paolo ^c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZENESULFONYLINDOLE DERIVATIVE; 2 METHYLPHENYLSULFONYL DERIVATIVE; 3 BENZENESULFONYLINDOLE DERIVATIVE; 3 METHYLPHENYLSULFONYL DERIVATIVE; 5 BROMO 3 [(3,5 DIMETHYLPHENYL)SULFONYL] 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO 3 [(3,5 DIMETHYLPHENYL)SULFONYL] 1H INDOLE 2 CARBOXAMIDE; ANTIRETROVIRUS AGENT; INDOLYLSULFONE DERIVATIVE; L 737126; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; CELL LINE; DRUG RESISTANCE, VIRAL; HIV-1; HUMANS; INDOLES; MUTATION; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 12444315080     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0211063     Document Type: Article

References (17)

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