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Volumn 55, Issue 11, 2012, Pages 5425-5432

Characterization and solubilization of pyrrole-imidazole polyamide aggregates

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; IMIDAZOLE DERIVATIVE; POLYAMIDE; PYRROLE DERIVATIVE;

EID: 84862298240     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300380a     Document Type: Article
Times cited : (36)

References (42)
  • 1
    • 0034830898 scopus 로고    scopus 로고
    • Molecular recognition of DNA by small molecules
    • Dervan, P. B. Molecular recognition of DNA by small molecules Bioorg. Med. Chem. 2001, 9, 2215-2235
    • (2001) Bioorg. Med. Chem. , vol.9 , pp. 2215-2235
    • Dervan, P.B.1
  • 2
    • 0037832279 scopus 로고    scopus 로고
    • Recognition of the DNA minor groove by pyrrole-imidazole polyamides
    • Dervan, P. B.; Edelson, B. S. Recognition of the DNA minor groove by pyrrole-imidazole polyamides Curr. Opin. Struct. Biol. 2003, 13, 284-299
    • (2003) Curr. Opin. Struct. Biol. , vol.13 , pp. 284-299
    • Dervan, P.B.1    Edelson, B.S.2
  • 3
    • 55249093393 scopus 로고    scopus 로고
    • Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells
    • Hsu, C. F.; Dervan, P. B. Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells Bioorg. Med. Chem. Lett. 2008, 18, 5851-5855
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 5851-5855
    • Hsu, C.F.1    Dervan, P.B.2
  • 6
    • 69449087887 scopus 로고    scopus 로고
    • Allosteric modulation of DNA by small molecules
    • Chenoweth, D. M.; Dervan, P. B. Allosteric modulation of DNA by small molecules Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 13175-13179
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 13175-13179
    • Chenoweth, D.M.1    Dervan, P.B.2
  • 7
    • 84862303083 scopus 로고    scopus 로고
    • 13175/13171-S13175/13110
    • S13175/13171-S13175/13110.
  • 8
    • 77958046177 scopus 로고    scopus 로고
    • Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding
    • Chenoweth, D. M.; Dervan, P. B. Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding J. Am. Chem. Soc. 2010, 132, 14521-14529
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 14521-14529
    • Chenoweth, D.M.1    Dervan, P.B.2
  • 9
    • 34547496561 scopus 로고    scopus 로고
    • Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide
    • Nickols, N. G.; Dervan, P. B. Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 10418-10423
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 10418-10423
    • Nickols, N.G.1    Dervan, P.B.2
  • 10
    • 34548581017 scopus 로고    scopus 로고
    • Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface
    • Nickols, N. G.; Jacobs, C. S.; Farkas, M. E.; Dervan, P. B. Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface ACS Chem. Biol. 2007, 2, 561-571
    • (2007) ACS Chem. Biol. , vol.2 , pp. 561-571
    • Nickols, N.G.1    Jacobs, C.S.2    Farkas, M.E.3    Dervan, P.B.4
  • 11
    • 70349731736 scopus 로고    scopus 로고
    • Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression
    • Muzikar, K. A.; Nickols, N. G.; Dervan, P. B. Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 16598-16603
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 16598-16603
    • Muzikar, K.A.1    Nickols, N.G.2    Dervan, P.B.3
  • 12
    • 84862295732 scopus 로고    scopus 로고
    • 16598/16591-S16598/16596
    • S16598/16591-S16598/16596.
  • 13
  • 16
    • 60149106394 scopus 로고    scopus 로고
    • A pyrrole-imidazole polyamide targeting transforming growth factor-beta1 inhibits restenosis and preserves endothelialization in the injured artery
    • Yao, E.-H.; Fukuda, N.; Ueno, T.; Matsuda, H.; Nagase, H.; Matsumoto, Y.; Sugiyama, H.; Matsumoto, K. A pyrrole-imidazole polyamide targeting transforming growth factor-beta1 inhibits restenosis and preserves endothelialization in the injured artery Cardiovasc. Res. 2009, 81, 797-804
    • (2009) Cardiovasc. Res. , vol.81 , pp. 797-804
    • Yao, E.-H.1    Fukuda, N.2    Ueno, T.3    Matsuda, H.4    Nagase, H.5    Matsumoto, Y.6    Sugiyama, H.7    Matsumoto, K.8
  • 18
    • 70149095918 scopus 로고    scopus 로고
    • Cyclic Pyrrole-Imidazole Polyamides Targeted to the Androgen Response Element
    • Chenoweth, D. M.; Harki, D. A.; Phillips, J. W.; Dose, C.; Dervan, P. B. Cyclic Pyrrole-Imidazole Polyamides Targeted to the Androgen Response Element J. Am. Chem. Soc. 2009, 131, 7182-7188
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 7182-7188
    • Chenoweth, D.M.1    Harki, D.A.2    Phillips, J.W.3    Dose, C.4    Dervan, P.B.5
  • 20
    • 84860844719 scopus 로고    scopus 로고
    • Pharmacokinetics of Py-Im Polyamides Depend on Architecture: Cyclic versus Linear
    • Raskatov, J. A.; Hargrove, A. E.; Dervan, P. B. Pharmacokinetics of Py-Im Polyamides Depend on Architecture: Cyclic versus Linear J. Am. Chem. Soc. 2012, 134, 7995-7999
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 7995-7999
    • Raskatov, J.A.1    Hargrove, A.E.2    Dervan, P.B.3
  • 21
    • 84858378568 scopus 로고    scopus 로고
    • Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns
    • Meier, J. L.; Montgomery, D. C.; Dervan, P. B. Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns Nucleic Acids Res. 2011, 40, 2345-2356
    • (2011) Nucleic Acids Res. , vol.40 , pp. 2345-2356
    • Meier, J.L.1    Montgomery, D.C.2    Dervan, P.B.3
  • 24
    • 33847094111 scopus 로고    scopus 로고
    • Stability and equilibria of promiscuous aggregates in high protein milieus
    • Coan, K. E. D.; Shoichet, B. K. Stability and equilibria of promiscuous aggregates in high protein milieus Mol. BioSyst. 2007, 3, 208-213
    • (2007) Mol. BioSyst. , vol.3 , pp. 208-213
    • Coan, K.E.D.1    Shoichet, B.K.2
  • 25
    • 47749106894 scopus 로고    scopus 로고
    • Stoichiometry and Physical Chemistry of Promiscuous Aggregate-Based Inhibitors
    • Coan, K. E. D.; Shoichet, B. K. Stoichiometry and Physical Chemistry of Promiscuous Aggregate-Based Inhibitors J. Am. Chem. Soc. 2008, 130, 9606-9612
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 9606-9612
    • Coan, K.E.D.1    Shoichet, B.K.2
  • 27
    • 0141923641 scopus 로고    scopus 로고
    • Identification and prediction of promiscuous aggregating inhibitors among known drugs
    • Shoichet, B. K.; Seidler, J.; McGovern, S. L.; Doman, T. N. Identification and prediction of promiscuous aggregating inhibitors among known drugs J. Med. Chem. 2003, 46, 4477-4486
    • (2003) J. Med. Chem. , vol.46 , pp. 4477-4486
    • Shoichet, B.K.1    Seidler, J.2    McGovern, S.L.3    Doman, T.N.4
  • 28
    • 15444366107 scopus 로고    scopus 로고
    • Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability
    • Frenkel, Y. V.; Clark, A. D., Jr.; Das, K.; Wang, Y. H.; Lewi, P. J.; Janssen, P. A.; Arnold, E. Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability J. Med. Chem. 2005, 48, 1974-1983
    • (2005) J. Med. Chem. , vol.48 , pp. 1974-1983
    • Frenkel, Y.V.1    Clark Jr., A.D.2    Das, K.3    Wang, Y.H.4    Lewi, P.J.5    Janssen, P.A.6    Arnold, E.7
  • 29
    • 77952733763 scopus 로고    scopus 로고
    • Colloid formation by drugs in simulated intestinal fluid
    • Doak, A. K.; Wille, H.; Prusiner, S. B.; Shoichet, B. K. Colloid formation by drugs in simulated intestinal fluid J. Med. Chem. 2010, 53, 4259-4265
    • (2010) J. Med. Chem. , vol.53 , pp. 4259-4265
    • Doak, A.K.1    Wille, H.2    Prusiner, S.B.3    Shoichet, B.K.4
  • 30
    • 70149095918 scopus 로고    scopus 로고
    • Cyclic pyrrole-imidazole polyamides targeted to the androgen response element
    • Chenoweth, D. M.; Harki, D. A.; Phillips, J. W.; Dose, C.; Dervan, P. B. Cyclic pyrrole-imidazole polyamides targeted to the androgen response element J. Am. Chem. Soc. 2009, 131, 7182-7188
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 7182-7188
    • Chenoweth, D.M.1    Harki, D.A.2    Phillips, J.W.3    Dose, C.4    Dervan, P.B.5
  • 31
    • 44349123357 scopus 로고    scopus 로고
    • Next Generation Hairpin Polyamides with (R)-3,4-Diaminobutyric Acid Turn Unit
    • Dose, C.; Farkas, M. E.; Chenoweth, D. M.; Dervan, P. B. Next Generation Hairpin Polyamides with (R)-3,4-Diaminobutyric Acid Turn Unit J. Am. Chem. Soc. 2008, 130, 6859-6866
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 6859-6866
    • Dose, C.1    Farkas, M.E.2    Chenoweth, D.M.3    Dervan, P.B.4
  • 32
    • 72249122756 scopus 로고    scopus 로고
    • Modifications at the C-Terminus to Improve Pyrrole-Imidazole Polyamide Activity in Cell Culture
    • Jacobs, C. S.; Dervan, P. B. Modifications at the C-Terminus To Improve Pyrrole-Imidazole Polyamide Activity in Cell Culture J. Med. Chem. 2009, 52, 7380-7388
    • (2009) J. Med. Chem. , vol.52 , pp. 7380-7388
    • Jacobs, C.S.1    Dervan, P.B.2
  • 33
    • 0033576975 scopus 로고    scopus 로고
    • Cycle Polyamide Motif for Recognition of the Minor Groove of DNA
    • Herman, D. M.; Turner, J. M.; Baird, E. E.; Dervan, P. B. Cycle Polyamide Motif for Recognition of the Minor Groove of DNA J. Am. Chem. Soc. 1999, 121, 1121-1129
    • (1999) J. Am. Chem. Soc. , vol.121 , pp. 1121-1129
    • Herman, D.M.1    Turner, J.M.2    Baird, E.E.3    Dervan, P.B.4
  • 34
    • 0036280321 scopus 로고    scopus 로고
    • Solid-phase synthesis of DNA binding polyamides on oxime resin
    • Belitsky, J. M.; Nguyen, D. H.; Wurtz, N. R.; Dervan, P. B. Solid-phase synthesis of DNA binding polyamides on oxime resin Bioorg. Med. Chem. 2002, 10, 2767-2774
    • (2002) Bioorg. Med. Chem. , vol.10 , pp. 2767-2774
    • Belitsky, J.M.1    Nguyen, D.H.2    Wurtz, N.R.3    Dervan, P.B.4
  • 36
    • 0032564881 scopus 로고    scopus 로고
    • Stereochemical control of the DNA binding affinity, sequence specificity, and orientation preference of chiral hairpin polyamides in the minor groove
    • Herman, D. M.; Baird, E. E.; Dervan, P. B. Stereochemical control of the DNA binding affinity, sequence specificity, and orientation preference of chiral hairpin polyamides in the minor groove J. Am. Chem. Soc. 1998, 120, 1382-1391
    • (1998) J. Am. Chem. Soc. , vol.120 , pp. 1382-1391
    • Herman, D.M.1    Baird, E.E.2    Dervan, P.B.3
  • 37
    • 78649654159 scopus 로고    scopus 로고
    • Pharmaceutical applications of cyclodextrins: Basic science and product development
    • Loftsson, T.; Brewster, M. E. Pharmaceutical applications of cyclodextrins: basic science and product development J. Pharm. Pharmacol. 2010, 62, 1607-1621
    • (2010) J. Pharm. Pharmacol. , vol.62 , pp. 1607-1621
    • Loftsson, T.1    Brewster, M.E.2
  • 38
    • 21844459973 scopus 로고    scopus 로고
    • 2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD): A toxicology review
    • Gould, S.; Scott, R. C. 2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD): a toxicology review Food Chem. Toxicol. 2005, 43, 1451-1459
    • (2005) Food Chem. Toxicol. , vol.43 , pp. 1451-1459
    • Gould, S.1    Scott, R.C.2
  • 39
    • 80052950545 scopus 로고    scopus 로고
    • Evaluation of PI polyamide conjugates with eight-base pair recognition and improvement of the aqueous solubility by PEGylation
    • Takagaki, T.; Bando, T.; Kitano, M.; Hashiya, K.; Kashiwazaki, G.; Sugiyama, H. Evaluation of PI polyamide conjugates with eight-base pair recognition and improvement of the aqueous solubility by PEGylation Bioorg. Med. Chem. 2011, 19, 5896-5902
    • (2011) Bioorg. Med. Chem. , vol.19 , pp. 5896-5902
    • Takagaki, T.1    Bando, T.2    Kitano, M.3    Hashiya, K.4    Kashiwazaki, G.5    Sugiyama, H.6
  • 41
    • 0346461917 scopus 로고    scopus 로고
    • Introduction and general overview of cyclodextrin chemistry
    • Szejtli, J. Introduction and general overview of cyclodextrin chemistry Chem. Rev. 1998, 98, 1743-1753
    • (1998) Chem. Rev. , vol.98 , pp. 1743-1753
    • Szejtli, J.1
  • 42
    • 0029819323 scopus 로고    scopus 로고
    • Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization
    • Loftsson, T.; Brewster, M. E. Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization J. Pharm. Sci. 1996, 85, 1017-1025
    • (1996) J. Pharm. Sci. , vol.85 , pp. 1017-1025
    • Loftsson, T.1    Brewster, M.E.2


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