Evaluation of PI polyamide conjugates with eight-base pair recognition and improvement of the aqueous solubility by PEGylation

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 19, 2011, Pages 5896-5902

  Takagaki, Toshiki ^a   Bando, Toshikazu ^a   Kitano, Masaaki ^a   Hashiya, Kaori ^a   Kashiwazaki, Gengo ^a   Sugiyama, Hiroshi ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Alkylating agent; Antitumor agent; Minor groove binder; PEGylation; PI polyamide

Indexed keywords

ALKYLATING AGENT; DNA FRAGMENT; MACROGOL DERIVATIVE; METHOXYPOLYETHYLENE GLYCOL 750; N METHYL PYRROLE N METHYLIMIDAZOLE POLYAMIDE CONJUGATE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; BASE PAIRING; CANCER CELL CULTURE; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; GENOME SIZE; HUMAN; HUMAN CELL; HYDROPHILICITY; IC 50; LUNG ADENOCARCINOMA; MOLECULAR RECOGNITION; PEGYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROSTATE CARCINOMA; REACTION ANALYSIS;

ANTINEOPLASTIC AGENTS, ALKYLATING; BASE PAIRING; CELL LINE, TUMOR; DRUG DESIGN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; IMIDAZOLES; NYLONS; POLYETHYLENE GLYCOLS; PYRROLES; SOLUBILITY; WATER;

EID: 80052950545     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.08.009     Document Type: Article

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