A high-affinity natural autoantibody from human cord blood defines a physiologically relevant epitope on the FcεRIα

Journal of Immunology

Volumn 175, Issue 10, 2005, Pages 6589-6596

  Bobrzynski, Tomasz ^a   Fux, Michaela ^a   Vogel, Monique ^a   Stadler, Michael B ^b   Stadler, Beda M ^a   Miescher, Sylvia M ^a,c,d  

^a UNIVERSITY OF BERN   (Switzerland)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c ZLB Behring   (Switzerland)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CBMALPHA8 ANTIBODY; EPITOPE; HIGH AFFINITY IMMUNOGLOBULIN E RECEPTOR; HIGH AFFINITY IMMUNOGLOBULIN E RECEPTOR ANTIBODY; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E RECEPTOR; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY; RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANAPHYLACTOGENIC ACTIVITY; ANAPHYLAXIS; ANTIBODY AFFINITY; ANTIBODY LIBRARY; ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; BINDING COMPETITION; BINDING SITE; BIOLOGICAL ACTIVITY; DONOR; ESCAPE MUTANT; FEMALE; GERM LINE; HUMAN; HUMAN CELL; INNATE IMMUNITY; MALE; MUTANT; NEWBORN; NORMAL HUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; RECEPTOR BINDING; UMBILICAL CORD BLOOD; URTICARIA;

EID: 27744516891     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.10.6589     Document Type: Article

References (62)

1. Parker, W., P. B. Yu, Z. E. Holzknecht, K. Lundberg, R. H. Buckley, and J. L. Platt. 1997. Specificity and function of "natural" antibodies in immunodeficient subjects: clues to B cell lineage and development. J. Clin. Immunol. 17: 311-321.
2. Coutinho, A., M. D. Kazatchkine, and S. Avrameas. 1995. Natural autoantibodies. Curr. Opin. Immunol. 7: 812-818.
3. Boes, M. 2000. Role of natural and immune IgM antibodies in immune responses. Mol. Immunol. 37: 1141-1149.
4. Stahl, D., and W. Sibrowski. 2003. Regulation of the immune response by natural IgM: lessons from warm autoimmune hemolytic anemia. Curr. Pharm. Des. 9: 1871-1880.
5. Rodman, T. C., S. E. To, J. J. Sullivan, and R. Winston. 1997. Innate natural antibodies: primary roles indicated by specific epitopes. Hum. Immunol. 55: 87-95.
6. Ochsenbein, A. F., and R. M. Zinkernagel. 2000. Natural antibodies and complement link innate and acquired immunity. Immunol. Today 21: 624-630.
7. Vollmers, H. P., and S. Brandlein. 2002. Nature's best weapons to fight cancer: revival of human monoclonal IgM antibodies. Hum. Antibodies 11: 131-142.
8. Lacroix-Desmazes, S., S. V. Kaveri, L. Mouthon, A. Ayouba, E. Malanchere, A. Coutinho, and M. D. Kazatchkine. 1998. Self-reactive antibodies (natural autoantibodies) in healthy individuals. J. Immunol. Methods 216: 117-137.
9. Kohler, H., J. Bayry, A. Nicoletti, and S. V. Kaveri. 2003. Natural autoantibodies as tools to predict the outcome of immune response? Scand. J. Immunol. 58: 285-289.
10. Mouthon, L., A. Nobrega, N. Nicolas, S. V. Kaveri, C. Barreau, A. Coutinho, and M. D. Kazatchkine. 1995. Invariance and restriction toward a limited set of self-antigens characterize neonatal IgM antibody repertoires and prevail in autoreactive repertoires of healthy adults. Proc. Natl. Acad. Sci. USA 92: 3839-3843.
11. Horn, M. P., J. M. Pachlopnik, M. Vogel, M. Dahinden, F. Wurm, B. M. Stadler, and S. M. Miescher. 2001. Conditional autoimmunity mediated by human natural anti-FcεRIα autoantibodies? FASEB J. 15: 2268-2274.
12. Miescher, S. M., M. P. Horn, J. M. Pachlopnik, L. Baldi, M. Vogel, and B. M. Stadler. 2001. Natural anti-FcεRIα autoantibodies isolated from healthy donors and chronic idiopathic urticaria patients reveal a restricted repertoire and autoreactivity on human basophils. Hum. Antibodies 10: 119-126.
13. Kaplan, A. P. 2002. Clinical practice: chronic urticaria and angioedema. N. Engl. J. Med. 346: 175-179.
14. Horn, M. P., T. Gerster, B. Ochensberger, T. Derer, F. Kricek, M. H. Jouvin, J. P. Kinet, T. Tschernig, M. Vogel, B. M. Stadler, et al. 1999. Human anti-FcεRIα autoantibodies isolated from healthy donors cross-react with tetanus toxoid. Eur. J. Immunol. 29: 1139-1148.
15. Avrech, O. M., Z. Samra, Z. Lazarovich, E. Caspi, A. Jacobovich, and D. Sompolinsky. 1994. Efficacy of the placental barrier for immunoglobulins: correlations between maternal, paternal and fetal immunoglobulin levels. Int. Arch. Allergy Immunol. 103: 160-165.
16. H segments with different hypervariable loops. J. Mol. Biol. 227: 776-798.
17. Williams, S. C., J. P. Frippiat, I. M. Tomlinson, O. Ignatovich, M. P. Lefranc, and G. Winter. 1996. Sequence and evolution of the human germline Vλ repertoire. J. Mol. Biol. 264: 220-232.
18. Cox, J. P., I. M. Tomlinson, and G. Winter. 1994. A directory of human germ-line Vκ segments reveals a strong bias in their usage. Eur. J. Immunol. 24: 827-836.
19. Williams, S. C., and G. Winter. 1993. Cloning and sequencing of human immunoglobulin Vλ gene segments. Eur. J. Immunol. 23: 1456-1461.
20. Tomlinson, I. M., J. P. Cox, E. Gherardi, A. M. Lesk, and C. Chothia. 1995. The structural repertoire of the human Vκ domain. EMBO J. 14: 4628-4638.
21. Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215: 403-410.
22. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159.
23. Endege, W. O., K. E. Steinmann, L. A. Boardman, S. N. Thibodeau, and R. Schlegel. 1999. Representative cDNA libraries and their utility in gene expression profiling. BioTechniques 26: 542-548.
24. Desogus, A., R. Burioni, A. Ingianni, F. Bugli, R. Pompei, and G. Fadda. 2003. Production and characterization of a human recombinant monoclonal Fab fragment specific for influenza A viruses. Clin. Diagn. Lab. Immunol. 10: 680-685.
25. Pachlopnik, J. M., M. P. Horn, M. Fux, M. Dahinden, M. Mandallaz, D. Schneeberger, L. Baldi, M. Vogel, B. M. Stadler, and S. M. Miescher. 2004. Natural anti-FcεRIα autoantibodies may interfere with diagnostic tests for autoimmune urticaria. J. Autoimmun. 22: 43-51.
26. Engelhardt, O., R. Grabherr, G. Himmler, and F. Ruker. 1994. Two-step cloning of antibody variable domains in a phage display vector. BioTechniques 17: 44-46.
27. Kang, A. S., C. F. Barbas, K. D. Janda, S. J. Benkovic, and R. A. Lerner. 1991. Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces. Proc Natl Acad Sci USA 88: 4363-4366.
28. Barbas, C. F., III, A. S. Kang, R. A. Lerner, and S. J. Benkovic. 1991. Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. Proc. Natl. Acad. Sci. USA 88: 7978-7982.
29. Vogel, M., S. Miescher, C. Biaggi, and B. M. Stadler. 1994. Human anti-IgE antibodies by repertoire cloning. Eur. J. Immunol. 24: 1200-1207.
30. H repertoire. Immunol. Today 16: 237-242.
31. Knutti-Muller, J. M., B. M. Stadler, C. M. Magnusson, and L. de Weck. 1986. Human IgE synthesis in vitro: detection with monoclonal antibodies. Allergy 41: 457-467.
32. Zurcher, A. W., A. B. Lang, I. Aebischer, S. Miescher, and B. M. Stadler. 1995. IgE-producing hybridomas established after B-cell culture in the CD40 system. Immunol. Lett. 46: 49-57.
33. H in the human genome. J. Mol. Biol. 341: 477-489.
34. Persic, L., A. Roberts, J. Wilton, A. Cattaneo, A. Bradbury, and H. R. Hoogenboom. 1997. An integrated vector system for the eukaryotic expression of antibodies or their fragments after selection from phage display libraries. Gene 187: 9-18.
35. Alber, G., U. M. Kent, and H. Metzger. 1992. Functional comparison of FcεRI, FCγRII, and FCγRIII in mast cells. J. Immunol. 149: 2428-2436.
36. Roa, M., F. Paumet, J. Le Mao, B. David, and U. Blank. 1997. Involvement of the ras-like GTPase rab3d in RBL-2H3 mast cell exocytosis following stimulation via high affinity IgE receptors (FcεRI). J. Immunol. 159: 2815-2823.
37. Nechansky, A., M. W. Robertson, B. A. Albrecht, J. R. Apgar, and F. Kricek. 2001. Inhibition of antigen-induced mediator release from IgE-sensitized cells by a monoclonal anti-FcεRI α-chain receptor antibody: implications for the involvement of the membrane-proximal α-chain region in FcεRI-mediated cell activation. J. Immunol. 166: 5979-5990.
38. H gene repertoire by an anchored PCR-ELISA. Ann. NY Acad. Sci. 764: 463-473.
39. Van Dijk-Hard, I., and I. Lundkvist. 2002. Long-term kinetics of adult human antibody repertoires. Immunology 107: 136-144.
40. Combriato, G., and H. G. Klobeck. 1991. Vλ and Jλ-Cλ gene segments of the human immunoglobulin λ light chain locus are separated by 14 kb and rearrange by a deletion mechanism. Eur. J. Immunol. 21: 1513-1522.
41. Chothia, C., and A. M. Lesk. 1987. Canonical structures for the hypervariable regions of immunoglobulins. J. Mol. Biol. 196: 901-917.
42. Al-Lazikani, B., A. M. Lesk, and C. Chothia. 1997. Standard conformations for the canonical structures of immunoglobulins. J. Mol. Biol. 273: 927-948.
43. Shirai, H., A. Kidera, and H. Nakamura. 1996. Structural classification of CDR-H3 in antibodies. FEBS Lett. 399: 1-8.
44. Nechansky, A., E. Pursch, F. Effenberger, and F. Kricek. 1997. Characterization of monoclonal antibodies directed against the α-subunit of the human IgE high-affinity receptor. Hybridoma 16: 441-446.
45. Kazatchkine, M. D., and S. V. Kaveri. 2001. Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. N. Engl. J. Med. 345: 747-755.
46. Bischoff, S. C., R. Zwahlen, M. Stucki, G. Mullner, A. L. de Weck, B. M. Stadler, and C. A. Dahinden. 1996. Basophil histamine release and leukotriene production in response to anti-IgE and anti-IgE receptor antibodies: comparison of normal subjects and patients with urticaria, atopic dermatitis or bronchial asthma. Int. Arch. Allergy Immunol. 110: 261-271.
47. de Bernard, M., A. Cappon, L. Pancotto, P. Ruggiero, J. Rivera, G. Del Giudice, and C. Montecucco. 2005. The Helicobacter pylori VacA cytotoxin activates RBL-2H3 cells by inducing cytosolic calcium oscillations. Cell. Microbiol. 7: 191-198.
48. Busse, W., J. Corren, B. Q. Lanier, M. McAlary, A. Fowler-Taylor, G. D. Cioppa, A. van As, and N. Gupta. 2001. Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma. J. Allergy Clin. Immunol. 108: 184-190.
49. Easthope, S., and B. Jarvis. 2001. Omalizumab. Drugs 61: 253-260.
50. O'Donnell, B. F., R. M. Barr, A. K. Black, D. M. Francis, F. Kermani, N. Niimi, R. J. Barlow, R. K. Winkelmann, and M. W. Greaves. 1998. Intravenous immunoglobulin in autoimmune chronic urticaria. Br. J. Dermatol. 138: 101-106.
51. Bayry, J., N. Misra, V. Latry, F. Prost, S. Delignat, S. Lacroix-Desmazes, M. D. Kazatchkine, and S. V. Kaveri. 2003. Mechanisms of action of intravenous immunoglobulin in autoimmune and inflammatory diseases. Transfus. Clin. Biol. 10: 165-169.
52. Lo Conte, L., C. Chothia, and J. Janin. 1999. The atomic structure of protein-protein recognition sites. J. Mol. Biol. 285: 2177-2198.
53. Sabroe, R. A., C. E. Grattan, D. M. Francis, R. M. Barr, A. Kobza Black, and M. W. Greaves. 1999. The autologous serum skin test: a screening test for autoantibodies in chronic idiopathic urticaria. Br. J. Dermatol 140: 446-452.
54. Fiebiger, E., D. Maurer, H. Holub, B. Reininger, G. Hartmann, M. Woisetschlager, J. P. Kinet, and G. Stingl. 1995. Serum IgG autoantibodies directed against the α chain of FcεRI: a selective marker and pathogenetic factor for a distinct subset of chronic urticaria patients? J. Clin. Invest. 96: 2606-2612.
55. Sabroe, R. A., E. Fiebiger, D. M. Francis, D. Maurer, P. T. Seed, C. E. Grattan, A. K. Black, G. Stingl, M. W. Greaves, and R. M. Barr. 2002. Classification of anti-FcεRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity. J. Allergy Clin. Immunol. 110: 492-499.
56. Rodman, T. C., J. D. Lutton, S. Jiang, H. B. Al-Kouatly, and R. Winston. 2001. Circulating natural IgM antibodies and their corresponding human cord blood cell-derived Mabs specifically combat the Tat protein of HIV. Exp. Hematol. 29: 1004-1009.
57. L segments of polyreactive and monoreactive human natural antibodies to HIV-1 and Escherichia coli β-galactosidase. Int. Immunol. 5: 1523-1533.
58. Chen, X. J., and L. Enerback. 2000. Regulation of IgE-receptor expression, IgE occupancy and secretory capacity of mast cells. APMIS 108: 633-641.
59. Dietrich, G., S. V. Kaveri, and M. D. Kazatchkine. 1992. Modulation of autoimmunity by intravenous immune globulin through interaction with the function of the immune/idiotypic network. Clin. Immunol. Immunopathol. 62: S73-S81.
60. Furuichi, K., J. Rivera, and C. Isersky. 1985. The receptor for immunoglobulin E on rat basophilic leukemia cells: effect of ligand binding on receptor expression. Proc. Natl. Acad. Sci. USA 82: 1522-1525.
61. Borkowski, T. A., M. H. Jouvin, S. Y. Lin, and J. P. Kinet. 2001. Minimal requirements for IgE-mediated regulation of surface FcεRI. J. Immunol. 167: 1290-1296.
62. Jensen, B. M., J. B. Hansen, S. Dissing, J. Gerwien, P. S. Skov, and L. K. Poulsen. 2003. Monomeric immunoglobulin E stabilizes FcεRIα from the human basophil cell line KU812 by protecting it from natural turnover. Clin. Exp. Allergy 33: 655-662.