A bioinformatics pipeline to build a knowledge database for in silico antibody engineering

Molecular Immunology

Volumn 48, Issue 8, 2011, Pages 1019-1026

  Zhao, Shanrong ^a   Lu, Jin ^b  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b CENTOCOR INC   (United States)

Author keywords

Algorithm; Antibody engineering; Bioinformatics; CDR IMGT; Germline; Hypermutation; Java; Knowledge database; Position specific scoring matrix; Somatic mutation; Web

Indexed keywords

ANTIBODY;

AMINO ACID SEQUENCE; ANTIBODY ENGINEERING; ARTICLE; BIOINFORMATICS; COMPLEMENTARITY DETERMINING REGION; COMPUTER MODEL; GENBANK; GENE REARRANGEMENT; GENETIC VARIABILITY; GERM LINE; IMMUNOGLOBULIN VARIABLE REGION; KNOWLEDGE BASE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SOMATIC HYPERMUTATION;

AMINO ACID SEQUENCE; ANTIBODIES; ANTIBODY DIVERSITY; COMPLEMENTARITY DETERMINING REGIONS; COMPUTATIONAL BIOLOGY; DATABASES, FACTUAL; GENE REARRANGEMENT; GERM CELLS; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; INFORMATION STORAGE AND RETRIEVAL; MOLECULAR SEQUENCE DATA; MUTATION; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 79952453760     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2011.01.009     Document Type: Article

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