Structure of human ADAM-8 catalytic domain complexed with batimastat

Acta Crystallographica Section F: Structural Biology and Crystallization Communications

Volumn 68, Issue 6, 2012, Pages 616-621

  Hall, Troii ^a   Shieh, Huey Sheng ^a   Day, Jacqueline E ^a   Caspers, Nicole ^a   Chrencik, Jill E ^a   Williams, Jennifer M ^a   Pegg, Lyle E ^a   Pauley, Adele M ^a   Moon, Andrea F ^b   Krahn, Joseph M ^b   Fischer, David H ^a   Kiefer, James R ^a,d   Tomasselli, Alfredo G ^a   Zack, Marc D ^c  

^a PFIZER INC   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c DOW AGROSCIENCES LLC   (United States)

^d GENENTECH INC   (United States)

Author keywords

ADAM 8; batimastat; inflammation; inhibitors; metalloproteases

Indexed keywords

ADAM PROTEIN; ADAM8 PROTEIN, HUMAN; BATIMASTAT; DRUG DERIVATIVE; LIGAND; MEMBRANE PROTEIN; PHENYLALANINE; PROTEINASE INHIBITOR; THIOPHENE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; HUMAN; METABOLISM; PROTEIN BINDING; PROTEIN UNFOLDING;

ADAM PROTEINS; CATALYTIC DOMAIN; HUMANS; LIGANDS; MEMBRANE PROTEINS; MODELS, MOLECULAR; PHENYLALANINE; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN UNFOLDING; THIOPHENES;

EID: 84862223556     PISSN: None     EISSN: 17443091     Source Type: Journal    
DOI: 10.1107/S1744309112015618     Document Type: Article

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