Batimastat, a potent matrix metalloproteinase inhibitor, exhibits an unexpected mode of binding

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 7, 1996, Pages 2749-2754

  Botos, Istvan ^a   Scapozza, Leonardo ^a   Zhang, Dachuan ^a   Liotta, Lance A ^b   Meyer, Edgar F ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

crystallography; drug design; metastasis; molecular modeling

Indexed keywords

ATROLYSIN C; BATIMASTAT; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVE SITE; ENZYME INHIBITOR COMPLEX; ENZYME SPECIFICITY; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BINDING SITES; COMPUTER SIMULATION; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; FOURIER ANALYSIS; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PHENYLALANINE; PROTEASE INHIBITORS; PROTEIN STRUCTURE, SECONDARY; THIOPHENES;

EID: 0029866390     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.7.2749     Document Type: Article

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