Using volumetric flow to scaleup chromatographic processes

BioPharm International

Volumn 19, Issue 3, 2006, Pages 34-44

  Kidal, Stefffen ^a,b   Jensen, Ole Elvang ^a,c  

^a NOVO NORDISK A S   (Denmark)

^b Novo Nordisk A/S ^*  (Denmark)

^c NONE   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMATOGRAPHY; DRUG INDUSTRY; EQUIPMENT; FLOW RATE; FOOD AND DRUG ADMINISTRATION; GOOD MANUFACTURING PRACTICE; REVIEW; SCALE UP; SEPARATION TECHNIQUE; VOLUMETRY;

EID: 33645048979     PISSN: 1542166X     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Review

References (8)

1. Amersham Pharmacia Biotech (now GE Healthcare). Ion Exchange Chromatography - Principles and Methods. Uppsala, Sweden; 2001 p.121
2. Wancat PC. Rate Controlled Separations. London; Chapman & Hall; 1994. p. 330
3. Stickel JJ and Fotopoulos A. Pressure-flow relationships for packed beds of compressible chromatography media at laboratory and production scale. Biotechnol. Prog. 2001; 17(4):744-751.
4. Hansen, E. Scale up on a volume basis - Theory and applications [thesis]. Novo Nordisk A/S, Copenhagen, Denmark; May 2002. (Private communication).
5. Fahrner RI, Iyer HV, Blank GS. The optimal flow rate and column length for maximum production rate of protein A affinity chromatography. Bioprocess Engineering 1999; 21:287-292.
6. McCue JT, Kemp G, Low D, Quinones-Garcia I. Evaluation of protein-A chromatography media. J. Chroma. A. 2003; 989:139-153.
7. Gagnon P. Avoiding instrument-associated aberrations in purification scale-up and scale-down. BioPharm 1997 March; 10(3):42-45.
8. Wancat PC. op. cit. p.328.