17β-estradiol attenuates neural cell apoptosis through inhibition of JNK phosphorylation in SCI rats and excitotoxicity induced by glutamate in vitro

International Journal of Neuroscience

Volumn 122, Issue 7, 2012, Pages 381-387

  Rong, Wei ^a   Wang, Jun ^a   Liu, Xiaoguang ^a   Jiang, Liang ^a   Wei, Feng ^a   Zhou, Hua ^a   Han, Xiaoguang ^a   Liu, Zhongjun ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

17 estradiol; apoptosis; JNK; spinal cord injury

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ESTRADIOL; GLUTAMIC ACID; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXCITOTOXICITY; FEMALE; IMMUNOHISTOCHEMISTRY; NERVE CELL; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; RAT; SPINAL CORD INJURY; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; ESTRADIOL; FEMALE; GLUTAMIC ACID; IN SITU NICK-END LABELING; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; PHOSPHORYLATION; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES; TETRAZOLIUM SALTS; THIAZOLES; TIME FACTORS;

EID: 84862204736     PISSN: 00207454     EISSN: 15635279     Source Type: Journal    
DOI: 10.3109/00207454.2012.668726     Document Type: Article

References (30)

1. Shuman SL, Bresnahan JC, BeattieMS. Apoptosis of microglia and oligodendrocytes after spinal cord contusion in rats. J Neurosci Res. 1997;50(5):798-808. (Pubitemid 27518276)
2. Crowe MJ, Bresnahan JC, Shuman SL, Masters JN, Beattie MS. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat Med. 1997;3(2):240.
3. Beattie MS. Inflammation and apoptosis: linked therapeutic targets in spinal cord injury. Trends Mol Med. 2004;10(12):580-3. (Pubitemid 39573147)
4. Yakovlev AG, Faden AI. Caspase-dependent apoptotic pathways in CNS injury. Mol Neurobiol. 2001;24(1-3):131-44. (Pubitemid 34066682)
5. Pereira JE, Costa LM, Cabrita AM, Couto PA, Filipe VM, Magalhães LG, Fornaro M, Di Scipio F, Geuna S, Maurício AC, Varejão AS.Methylprednisolone fails to improve functional and histological outcome following spinal cord injury in rats. Exp Neurol. 2009;220(1):71-81.
6. Mize AL. Estrogen receptor-mediated neuroprotection from oxidative stress requires activation of the mitogen-activated protein kinase pathway. Endocrinology. 2003;144(1):306-12. (Pubitemid 36082803)
7. Michaels RL, Rothman SM. Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations. J Neurosci. 1990;10(1):283-92. (Pubitemid 20059264)
8. Murphy TH, Miyamoto M, Sastre A, Schnaar RL, Coyle JT. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron. 1989;2(6):1547-58.
9. Sribnick EA, Wingrave JM, Matzelle DD, Ray SK, Banik NL. Estrogen as a neuroprotective agent in the treatment of spinal cord injury. Ann NY Acad Sci. 2003;993:125-33. (Pubitemid 36808442)
10. Bayir H,Marion DW, Puccio AM, Wisniewski SR, Janesko KL, Clark RS, Kochanek PM. Marked gender effect on lipid peroxidation after severe traumatic brain injury in adult patients. J Neurotrauma. 2004;21(1):1-8. (Pubitemid 38141797)
11. Das A, Smith JA, Gibson C, Varma AK, Ray SK, Banik NL. Estrogen receptor agonists and estrogen attenuate TNF-alpha-induced apoptosis in VSC4.1 motoneurons. J Endocrinol. 2011;208(2):171-82.
12. Genovese T, Melani A, Esposito E, Mazzon E, Di Paola R, Bramanti P, Pedata F, Cuzzocrea S. The selective adenosine A2A receptor agonist CGS 21680 reduces JNK MAPK activation in oligodendrocytes in injured spinal cord. Shock. 2009;32(6):578-85.
13. Esposito E, Genovese T, Caminiti R, Bramanti P, Meli R, Cuzzocrea S. Melatonin reduces stress-activated/mitogen-activated protein kinases in spinal cord injury. J Pineal Res. 2009;46(1):79-86.
14. Gao YJ, Ji RR. Activation of JNK pathway in persistent pain. Neurosci Lett. 2008;437(3):180-3.
15. Fan J, Xu GX, Nagel DJ, Hua Z, Zhang N, Yin G. A model of ischemia and reperfusion increases JNK activity, inhibits the association of BAD and 14-3-3, and induces apoptosis of rabbit spinal neurocytes. Neurosci Lett. 2010;473(3):196-201.
16. Mohamed MK, Abdel-Rahman AA. Effect of long-term ovariectomy and estrogen replacement on the expression of estrogen receptor gene in female rats. Eur J Endocrinol. 2000;142(3):307-14. (Pubitemid 30176942)
17. Perot PL Jr., Lee WA, Hsu CY, Hogan EL, Cox RD, Gross AJ. Therapeutic model for experimental spinal cord injury in the rat: I. Mortality and motor deficit. Cent Nerv Syst Trauma. 1987;4(3):149-59. (Pubitemid 18060082)
18. Han X, Yang N, Xu Y, Zhu J, Chen Z, Liu Z, Dang G, Song C. Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNF. Neurosci Lett. 2011;487(3):255-9.
19. Singer CA, Figueroa-Masot XA, Batchelor RH, Dorsa DM. The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons. J Neurosci. 1999;19(7):2455-63. (Pubitemid 29162395)
20. Yune TY, Kim SJ, Lee SM, Lee YK, Oh YJ, Kim YC, Markelonis GJ, Oh TH. Systemic administration of 17 beta-estradiol reduces apoptotic cell death and improves functional recovery following traumatic spinal cord injury in rats. J. Neurotrauma. 2004;21(3):293-306. (Pubitemid 38401751)
21. Garcia-Segura LM, Azcoitia I, DonCarlos LL. Neuroprotection by estradiol. Prog. Neurobiol. 2001;63(1):29-60.
22. Chen RW, Lu XC, Yao C, Liao Z, Jiang ZG, WeiH, Ghanbari HA, Tortella FC, Dave JR. PAN-811 provides neuroprotection against glutamate toxicity by suppressing activation of JNK and p38 MAPK. Neurosci Lett. 2007;422(1):64-7. (Pubitemid 47077577)
23. Williams GT, Smith CA, McCarthy NJ, Grimes EA. Apoptosis: final control point in cell biology. Trends Cell Biol. 1992;2(9):263-7.
24. Lou J, Lenke LG, Ludwig FJ, O'Brien MF. Apoptosis as a mechanism of neuronal cell death following acute experimental spinal cord injury. Spinal Cord. 1998;36(10):683-90. (Pubitemid 28479074)
25. Nakahara S, Yone K, Sakou T, Wada S, Nagamine T, Niiyama T, Ichijo H. Induction of apoptosis signal regulating kinase 1 (ASK1) after spinal cord injury in rats: possible involvement of ASK1-JNK and-p38 pathways in neuronal apoptosis. J Neuropath Exp Neurol. 1999;58(5):442-50. (Pubitemid 29220737)
26. Liu T, Jin H, Sun QR, Xu JH, Hu HT. Neuroprotective effects of emodin in rat cortical neurons against beta-amyloid-induced neurotoxicity. Brain Res. 2010;1347:149-60.
27. Lin A. Activation of the JNK signaling pathway: breaking the brake on apoptosis. BioEssays. 2003;25(1):17-24. (Pubitemid 36093321)
28. Nakamura M, Nakakimura K, Matsumoto M, Sakabe T. Rapid tolerance to focal cerebral ischemia in rats is attenuated by adenosine A1 receptor antagonist. J Cereb Blood Flow Metab. 2002;22(2):161-70. (Pubitemid 34135647)
29. Samantaray S, Sribnick EA, Das A, Thakore NP, Matzelle D, Yu SP, Ray SK, Wei L, Banik NL. Neuroprotective efficacy of estrogen in experimental spinal cord injury in rats. Ann NY Acad Sci. 2010;1199:90-4.
30. Perrella J, Bhavnani BR. Protection of cortical cells by equine estrogens against glutamate-induced excitotoxicity is mediated through a calcium independent mechanism. BMC Neurosci. 2005;6:34.