Structural analysis of staphylococcus aureus serine/threonine kinase PknB

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Rakette, Sonja ^a   Donat, Stefanie ^b   Ohlsen, Knut ^b   Stehle, Thilo ^a,c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; LIGAND; PROTEIN PKNB; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; CHEMICAL STRUCTURE; CHEMISTRY; CRYSTALLIZATION; ENZYMOLOGY; ISOLATION AND PURIFICATION; MASS SPECTROMETRY; METABOLISM; MOLECULAR CLONING; PHOSPHORYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN CONFORMATION; X RAY DIFFRACTION;

CLONING, MOLECULAR; CRYSTALLIZATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; MASS SPECTROMETRY; MODELS, MOLECULAR; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN-SERINE-THREONINE KINASES; STAPHYLOCOCCUS AUREUS; X-RAY DIFFRACTION;

EID: 84862196882     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039136     Document Type: Article

References (52)

1. Klevens RM, Morrison MA, Nadle J, Petit S, Gershman K, (2007) Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA: the journal of the American Medical Association 298: 1763 1771.
2. Hansra NK, Shinkai K, (2011) Cutaneous community-acquired and hospital-acquired methicillin-resistant Staphylococcus aureus. Dermatologic therapy 24: 263 272.
3. Bohach GA, Fast DJ, Nelson RD, Schlievert PM, (1990) Staphylococcal and streptococcal pyrogenic toxins involved in toxic shock syndrome and related illnesses. Critical reviews in microbiology 17: 251 272.
4. Lowy FD, (1998) Staphylococcus aureus infections. The New England journal of medicine 339: 520 532.
5. Deftereos SP, Michailidou E, Karagiannakis GK, Grigoriadi S, Prassopoulos P, (2009) Hematogenous infantile infection presenting as osteomyelitis and septic arthritis: a case report. Cases journal 2: 8293.
6. Aguilar J, Urday-Cornejo V, Donabedian S, Perri M, Tibbetts R, (2010) Staphylococcus aureus meningitis: case series and literature review. Medicine 89: 117 125.
7. Otto M, (2010) Looking toward basic science for potential drug discovery targets against community-associated MRSA. Medicinal research reviews 30: 1 22.
8. Hunter T, (1995) Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 80: 225 236.
9. Kennelly PJ, (2002) Protein kinases and protein phosphatases in prokaryotes: a genomic perspective. FEMS microbiology letters 206: 1 8.
10. Pereira SF, Goss L, Dworkin J, (2011) Eukaryote-like serine/threonine kinases and phosphatases in bacteria. Microbiology and molecular biology reviews: MMBR 75: 192 212.
11. Ruggiero A, Squeglia F, Marasco D, Marchetti R, Molinaro A, (2011) X-ray structural studies of the entire extracellular region of the serine/threonine kinase PrkC from Staphylococcus aureus. The Biochemical journal 435: 33 41.
12. Donat S, Streker K, Schirmeister T, Rakette S, Stehle T, (2009) Transcriptome and functional analysis of the eukaryotic-type serine/threonine kinase PknB in Staphylococcus aureus. Journal of bacteriology 191: 4056 4069.
13. Lomas-Lopez R, Paracuellos P, Riberty M, Cozzone AJ, Duclos B, (2007) Several enzymes of the central metabolism are phosphorylated in Staphylococcus aureus. FEMS microbiology letters 272: 35 42.
14. De Lencastre H, Wu SW, Pinho MG, Ludovice AM, Filipe S, (1999) Antibiotic resistance as a stress response: complete sequencing of a large number of chromosomal loci in Staphylococcus aureus strain COL that impact on the expression of resistance to methicillin. Microbial drug resistance 5: 163 175.
15. Yeats C, Finn RD, Bateman A, (2002) The PASTA domain: a beta-lactam-binding domain. Trends in biochemical sciences 27: 438.
16. Gordon E, Mouz N, Duee E, Dideberg O, (2000) The crystal structure of the penicillin-binding protein 2x from Streptococcus pneumoniae and its acyl-enzyme form: implication in drug resistance. Journal of molecular biology 299: 477 485.
17. Paracuellos P, Ballandras A, Robert X, Kahn R, Herve M, (2010) The extended conformation of the 2.9-A crystal structure of the three-PASTA domain of a Ser/Thr kinase from the human pathogen Staphylococcus aureus. Journal of molecular biology 404: 847 858.
18. Truong-Bolduc QC, Hooper DC, (2010) Phosphorylation of MgrA and its effect on expression of the NorA and NorB efflux pumps of Staphylococcus aureus. Journal of bacteriology 192: 2525 2534.
19. Tamber S, Schwartzman J, Cheung AL, (2010) Role of PknB kinase in antibiotic resistance and virulence in community-acquired methicillin-resistant Staphylococcus aureus strain USA300. Infection and immunity 78: 3637 3646.
20. Miller M, Donat S, Rakette S, Stehle T, Kouwen TR, (2010) Staphylococcal PknB as the first prokaryotic representative of the proline-directed kinases. PloS one 5: e9057.
21. Debarbouille M, Dramsi S, Dussurget O, Nahori MA, Vaganay E, (2009) Characterization of a serine/threonine kinase involved in virulence of Staphylococcus aureus. Journal of bacteriology 191: 4070 4081.
22. Lombana TN, Echols N, Good MC, Thomsen ND, Ng HL, (2010) Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknB. Structure 18: 1667 1677.
23. Ortiz-Lombardia M, Pompeo F, Boitel B, Alzari PM, (2003) Crystal structure of the catalytic domain of the PknB serine/threonine kinase from Mycobacterium tuberculosis. The Journal of biological chemistry 278: 13094 13100.
24. Young TA, Delagoutte B, Endrizzi JA, Falick AM, Alber T, (2003) Structure of Mycobacterium tuberculosis PknB supports a universal activation mechanism for Ser/Thr protein kinases. Nature structural biology 10: 168 174.
25. Mieczkowski C, Iavarone AT, Alber T, (2008) Auto-activation mechanism of the Mycobacterium tuberculosis PknB receptor Ser/Thr kinase. The EMBO journal 27: 3186 3197.
26. Wehenkel A, Fernandez P, Bellinzoni M, Catherinot V, Barilone N, (2006) The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria. FEBS letters 580: 3018 3022.
27. Kabsch W, (2010) Xds. Acta crystallographica Section D, Biological crystallography 66: 125 132.
28. McCoy AJ, Grosse-Kunstleve RW, Adams PD, Winn MD, Storoni LC, (2007) Phaser crystallographic software. Journal of applied crystallography 40: 658 674.
29. Emsley P, Lohkamp B, Scott WG, Cowtan K, (2010) Features and development of Coot. Acta crystallographica Section D, Biological crystallography 66: 486 501.
30. Adams PD, Afonine PV, Bunkoczi G, Chen VB, Davis IW, (2010) PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta crystallographica Section D, Biological crystallography 66: 213 221.
31. Brunger AT, (1992) Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. Nature 355: 472 475.
32. Schuttelkopf AW, van Aalten DM, (2004) PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Acta crystallographica Section D, Biological crystallography 60: 1355 1363.
33. Av-Gay Y, Jamil S, Drews SJ, (1999) Expression and characterization of the Mycobacterium tuberculosis serine/threonine protein kinase PknB. Infection and immunity 67: 5676 5682.
34. Karlsson R, Zheng J, Xuong N, Taylor SS, Sowadski JM, (1993) Structure of the mammalian catalytic subunit of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation. Acta crystallographica Section D, Biological crystallography 49: 381 388.
35. Zheng J, Trafny EA, Knighton DR, Xuong NH, Taylor SS, (1993) 2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor. Acta crystallographica Section D, Biological crystallography 49: 362 365.
36. Xu W, Doshi A, Lei M, Eck MJ, Harrison SC, (1999) Crystal structures of c-Src reveal features of its autoinhibitory mechanism. Molecular cell 3: 629 638.
37. Thompson JD, Higgins DG, Gibson TJ, (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic acids research 22: 4673 4680.
38. Gouet P, Courcelle E, Stuart DI, Metoz F, (1999) ESPript: analysis of multiple sequence alignments in PostScript. Bioinformatics 15: 305 308.
39. Gille C, Frommel C, (2001) STRAP: editor for STRuctural Alignments of Proteins. Bioinformatics 17: 377 378.
40. Taylor SS, Kornev AP, (2011) Protein kinases: evolution of dynamic regulatory proteins. Trends in biochemical sciences 36: 65 77.
41. Kornev AP, Haste NM, Taylor SS, Eyck LF, (2006) Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism. Proceedings of the National Academy of Sciences of the United States of America 103: 17783 17788.
42. Kornev AP, Taylor SS, (2010) Defining the conserved internal architecture of a protein kinase. Biochimica et biophysica acta 1804: 440 444.
43. Kornev AP, Taylor SS, Ten Eyck LF, (2008) A helix scaffold for the assembly of active protein kinases. Proceedings of the National Academy of Sciences of the United States of America 105: 14377 14382.
44. Bossemeyer D, (1994) The glycine-rich sequence of protein kinases: a multifunctional element. Trends in biochemical sciences 19: 201 205.
45. Saraste M, Sibbald PR, Wittinghofer A, (1990) The P-loop-a common motif in ATP- and GTP-binding proteins. Trends in biochemical sciences 15: 430 434.
46. Huse M, Kuriyan J, (2002) The conformational plasticity of protein kinases. Cell 109: 275 282.
47. Cox S, Radzio-Andzelm E, Taylor SS, (1994) Domain movements in protein kinases. Current opinion in structural biology 4: 893 901.
48. Johnson LN, Noble ME, Owen DJ, (1996) Active and inactive protein kinases: structural basis for regulation. Cell 85: 149 158.
49. Hubbard SR, (1999) Src autoinhibition: let us count the ways. Nature structural biology 6: 711 714.
50. Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz J, (1995) Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature 376: 313 320.
51. Alber T, (2009) Signaling mechanisms of the Mycobacterium tuberculosis receptor Ser/Thr protein kinases. Current opinion in structural biology 19: 650 657.
52. Schulze-Gahmen U, De Bondt HL, Kim SH, (1996) High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design. Journal of medicinal chemistry 39: 4540 4546.