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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 13, 2012, Pages 4396-4403

Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90

(12) Buchstaller, Hans Peter a Eggenweiler, Hans Michael a Sirrenberg, Christian a Grädler, Ulrich a Musil, Djordje a Hoppe, Edmund a Zimmermann, Astrid a Schwartz, Harry a März, Joachim a Bomke, Jörg a Wegener, Ansgar a Wolf, Michael a

a Merck Serono GmbH (Germany)

Author keywords

Anti cancer drug; Docking; Fragments; Heat shock protein 90; Hsp90; Indazoles; X ray structure

Indexed keywords

ADENOSINE TRIPHOSPHATE; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR;

ARTICLE; BINDING AFFINITY; CANCER CELL; CELL PROLIFERATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING;

AMIDES; BINDING SITES; CELL LINE, TUMOR; CELL SURVIVAL; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; HSP90 HEAT-SHOCK PROTEINS; HUMANS; INDAZOLES; PROTEIN STRUCTURE, TERTIARY; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862190612 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.04.121 Document Type: Article

Times cited : (21)

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