Effects of melatonin on islet neogenesis and beta cell apoptosis in streptozotocin-induced diabetic rats: An immunohistochemical study

Domestic Animal Endocrinology

Volumn 43, Issue 1, 2012, Pages 47-57

  Simsek, N ^a   Kaya, M ^a   Kara, A ^a   Can, I ^a   Karadeniz, A ^a   Kalkan, Y ^b  

^a ATATÜRK UNIVERSITY   (Turkey)

^b RECEP TAYYIP ERDOGAN UNIVERSITY   (Turkey)

Author keywords

Bcl xL; Beta cell neogenesis; Caspase 3; Diabetes; Insulin; Melatonin

Indexed keywords

MELATONIN;

ANIMAL; APOPTOSIS; ARTICLE; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; IMAGE PROCESSING; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; PANCREAS ISLET BETA CELL; PHYSIOLOGY; RANDOMIZATION; RAT; REGENERATION; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; DIABETES MELLITUS, EXPERIMENTAL; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; INSULIN-SECRETING CELLS; MALE; MELATONIN; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REGENERATION;

RATTUS;

EID: 84862142372     PISSN: 07397240     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.domaniend.2012.02.002     Document Type: Article

References (45)

1. Cemek M., Kaǧa S., Şimşek N., Büyükokuroǧlu M.E., Konuk M. Antihyperglycemic and antioxidative potential of Matricaria chamomilla L. In streptozotocin-induced diabetic rats. J Nat Med 2008, 62:284-293.
2. Thomas H.E., McKenzie M.D., Angstetra E., Campbell P.D., Kay T.W. Beta cell apoptosis in diabetes. Apoptosis 2009, 14:1389-1404.
3. Ryan A., Murphy M., Godson C., Hickey F.B. Diabetes mellitus and apoptosis: Inflammatory cells. Apoptosis 2009, 14:1435-1450.
4. Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 2001, 50:537-546.
5. Anwar M.M., Meki A.R. Oxidative stress in streptozotocin-induced diabetic rats: Effects of garlic oil and melatonin. Comp Biochem Physiol A Mol Integr Physiol 2003, 135:539-547.
6. Gürpinar T., Ekerbiçer N., Uysal N., Barut T., Tarakçi F., Tuǧlu M.I. The histologic evaluation of atorvastatin and melatonin treatment on oxidative stress and apoptosis of diabetic rat pancreas. Kafkas Univ Vet Fak Derg 2010, 16:547-552.
7. Donath M.Y., Storling J., Maedler K., Mandrup-Poulsen T. Inflammatory mediators and islet beta-cell failure: A link between type 1 and type 2 diabetes. J Mol Med 2003, 81:455-470.
8. Criddle D.N., Gerasimenko J.V., Baumgartner H.K., Jaffar M., Voronina S., Sutton R., Petersen O.H., Gerasimenko O.V. Calcium signalling and pancreatic cell death: Apoptosis or necrosis?. Cell Death Differ 2007, 14:1285-1294.
9. Biarnes M., Montolio M., Nacher V., Raurell M., Soler J., Montanya E. Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia. Diabetes 2002, 51:66-72.
10. Hui H., Dotta F., Di Mario U., Perfetti R. Role of caspases in the regulation of apoptotic pancreatic islet beta-cells death. J Cell Physiol 2004, 200:177-200.
11. Cnop M., Welsh N., Jonas J.C., Jorns A., Lenzen S., Eizirik D.L. Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: Many differences, few similarities. Diabetes 2005, 54(Suppl 2):S97-S107.
12. Eizirik D.L., Cardozo A.K., Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 2008, 29:42-61.
13. van der Kallen C.J., van Greevenbroek M.M., Stehouwer C.D., Schalkwijk C.G. Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: Is there a role for adipose tissue and liver?. Apoptosis 2009, 14:1424-1434.
14. Walker A., Taylor S.T., Hickman J.A., Dive C. Germinal center-derived signals act with bcl-2 to decrease apoptosis and increase clonogenicity of drug-treated human B lymphoma cells. Cancer Res 1997, 57:1939-1945.
15. Kanter M., Uysal H., Karaca T., Sagmanligil H.O. Depression of glucose levels and partial restoration of pancreatic beta-cell damage by melatonin in streptozotocin-induced diabetic rats. Arch Toxicol 2006, 80:362-369.
16. Mulder H., Nagorny C.L., Lyssenko V., Groop L. Melatonin receptors in pancreatic islets: Good morning to a novel type 2 diabetes gene. Diabetologia 2009, 52:1240-1249.
17. Bernard C., Berthault M.F., Saulnier C., Ktorza A. Neogenesis vs. apoptosis as main components of pancreatic beta cell mass changes in glucose-infused normal and mildly diabetic adult rats. FASEB J 1999, 13:1195-1205.
18. Drucker D.J. Glucagon-like peptide-1 and the islet beta-cell: Augmentation of cell proliferation and inhibition of apoptosis. Endocrinology 2003, 144:5145-5148.
19. Levetan C. Distinctions between islet neogenesis and beta-cell replication: Implications for reversal of type 1 and 2 diabetes. J Diabetes 2010, 2:76-84.
20. Teitelman G., Alpert S., Hanahan D. Proliferation, senescence, and neoplastic progression of beta cells in hyperplasic pancreatic islets. Cell 1988, 52:97-105.
21. Bonner-Weir S. Regulation of pancreatic beta-cell mass in vivo. Recent Prog Horm Res 1994, 49:91-104.
22. Del Zotto H., Massa L., Rafaeloff R., Pittenger G.L., Vinik A., Gold G., Reifel-Miller A., Gagliardino J.J. Possible relationship between changes in islet neogenesis and islet neogenesis-associated protein-positive cell mass induced by sucrose administration to normal hamsters. J Endocrinol 2000, 165:725-733.
23. Granata R., Volante M., Settanni F., Gauna C., Ghe C., Annunziata M., Deidda B., Gesmundo I., Abribat T., van der Lely A.J., Muccioli G., Ghigo E., Papotti M. Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats. J Mol Endocrinol 2010, 45:9-17.
24. Rooman I., Lardon J., Bouwens L. Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue. Diabetes 2002, 51:686-690.
25. Andersson A.K., Sandler S. Melatonin protects against streptozotocin, but not interleukin-1 beta-induced damage of rodent pancreatic beta-cells. J Pineal Res 2001, 30:157-165.
26. Baydas G., Canatan H., Turkoglu A. Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin-induced diabetes mellitus. Pineal Res 2002, 32:225-230.
27. Champney T.H., Holtorf A.P., Craft C.M., Reiter R.J. Hormonal modulation of pineal melatonin synthesis in rats and syrian hamsters: Effects of streptozotocin-induced diabetes and insulin injections. Comp Biochem Physiol A Comp Physiol 1986, 83:391-395.
28. Peschke E. Melatonin, endocrine pancreas and diabetes. J Pineal Res 2008, 44:26-40.
29. Aksoy N., Vural H., Sabuncu T., Aksoy S. Effects of melatonin on oxidative-antioxidative status of tissues in streptozotocin-induced diabetic rats. Cell Biochem Funct 2003, 21:121-125.
30. Sudnikovich E.J., Maksimchik Y.Z., Zabrodskaya S.V., Kubyshin V.L., Lapshina E.A., Bryszewska M., Reiter R.J., et al. Melatonin attenuates metabolic disorders due to streptozotocin-induced diabetes in rats. Eur J Pharmacol 2007, 569:180-187.
31. Rasmussen D.D., Boldt B.M., Wilkinson C.W., Yellon S.M., Matsumoto A.M. Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin, and plasma insulin to youthful levels. Endocrinology 1999, 140:1009-1012.
32. Peschke E., Stumpf I., Bazwinsky I., Litvak L., Dralle H., Muhlbauer E. Melatonin and type 2 diabetes - a possible link?. J Pineal Res 2007, 42:350-358.
33. Kumar S., Kesari K.K., Behari J. The therapeutic effect of a pulsed electromagnetic field on the reproductive patterns of male Wistar rats exposed to a 2.45-GHz microwave field. Clinics (Sao Paulo) 2011, 66:1237-1245.
34. Kozaki T., Lee S., Nishimura T., Katsuura T., Yasukouchi A. Effects of saliva collection using cotton swabs on melatonin enzyme immunoassay. J Circadian Rhythms 2011, 9:1.
35. Kanter M., Coskun O., Korkmaz A., Oter S. Effects of Nigella sativa on oxidative stress and beta-cell damage in streptozotocin-induced diabetic rats. Anat Rec A Discov Mol Cell Evol Biol 2004, 279:685-691.
36. Karaca T., Yoruk M., Yoruk I.H., Uslu S. Effects of extract of green tea and ginseng on pancreatic beta cells and levels of serum glucose, insulin, cholesterol and triglycerides in rats with experimentally streptozotocin-induced diabetes: a histochemical and immunohistochemical study. J Anim Vet Adv 2010, 9:102-107.
37. Bansal P., Paul P., Mudgal J., Nayak P.G., Thomas Pannakal S., Priyadarsini K.I., Unnikrishnan M.K. Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet/streptozotocin-induced diabetes in mice. Exp Toxicol Pathol 2011, [Epub ahead of print].
38. Vanecek J. Cellular mechanisms of melatonin action. Physiol Rev 1998, 78:687-721.
39. Peschke E., Wolgast S., Bazwinsky I., Ponicke K., Muhlbauer E. Increased melatonin synthesis in pineal glands of rats in streptozotocin induced type 1 diabetes. J Pineal Res 2008, 45:439-448.
40. Stumpf I., Muhlbauer E., Peschke E. Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells. J Pineal Res 2008, 45:318-327.
41. Conti A., Maestroni G.J. Role of the pineal gland and melatonin in the development of autoimmune diabetes in non-obese diabetic mice. J Pineal Res 1996, 20:164-172.
42. Şimşek N., Ergün E., Ergün L. Ankara Tavşaninda endokrin pankreas üzerine işik ve elektron mikroskobik araştirmalar. Ankara Üniv Vet Fak Derg 2010, 57:11-17.
43. Weichselbaum A. Uber die veranderungen des pankreas bei diabetes mellitus. Sitzungsber d kais Akad d Wassnsch-Math-Nat Kl 1910, 119:73-281.
44. Terazono K., Yamamoto H., Takasawa S., Shiga K., Yonemura Y., Tochino Y., Okamoto H. A novel gene activated in regenerating islets. J Biol Chem 1988, 263:2111-2114.
45. Champney T.H., Brainard G.C., Richardson B.A., Reiter R.J. Experimentally-induced diabetes reduces nocturnal pineal melatonin content in the Syrian hamster. Comp Biochem Physiol A Comp Physiol 1983, 76:199-201.