Evaluation of the binding orientations of testosterone in the active site of homology models for CYP2C11 and CYP2C13

Biochemical Pharmacology

Volumn 78, Issue 4, 2009, Pages 406-413

  Wang, Hongwu ^a   Cheng, Jemmie D ^a   Montgomery, Diana ^a   Cheng, K C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

CYP binding site; CYP2C; Homology modeling; Substrate docking; Testosterone metabolism

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2C11; CYTOCHROME P450 2C13; TESTOSTERONE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; HORMONE BINDING; HORMONE STRUCTURE; METABOLITE; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; TESTOSTERONE METABOLISM;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; BIOPHYSICAL PROCESSES; CATALYTIC DOMAIN; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; KINETICS; MICROSOMES, LIVER; MODELS, MOLECULAR; RATS; STEROID 16-ALPHA-HYDROXYLASE; SUBSTRATE SPECIFICITY; TESTOSTERONE;

EID: 67349240434     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.04.020     Document Type: Article

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