Impaired function and expression of P-glycoprotein in blood-brain barrier of streptozotocin-induced diabetic rats

Brain Research

Volumn 1123, Issue 1, 2006, Pages 245-252

  Liu, Haiyan ^a   Xu, Xiao ^a   Yang, Zhihong ^a   Deng, Yuanxiong ^a   Liu, Xiaodong ^a   Xie, Lin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Blood brain barrier; Diabetes mellitus; P glycoprotein; Rhodamine 123; Vincristine

Indexed keywords

EVANS BLUE; GLYCOPROTEIN P; RHODAMINE 123; STREPTOZOCIN; VINCRISTINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN MICROCIRCULATION; CELL CULTURE; CELL DAMAGE; CONTROLLED STUDY; ELECTRON MICROSCOPE; ENDOTHELIUM CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; STREPTOZOCIN DIABETES; WESTERN BLOTTING;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CEREBRAL CORTEX; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIAL CELLS; MALE; P-GLYCOPROTEIN; RATS; RATS, SPRAGUE-DAWLEY; RHODAMINE 123; STATISTICS, NONPARAMETRIC; VINCRISTINE;

EID: 33751194417     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.09.061     Document Type: Article

References (32)

1. Ando H., Nishio Y., Ito K., Nakao A., Wang L., and Zhao Y.L. Effect of endotoxin on P-glycoprotein mediated biliary and renal excretion of rhodamine-123 in rats. Antimicrob. Agents Chemother. 45 (2001) 3462-3467
2. Baria O., and Mutlu K. Influence of acute arterial hypertension on blood-brain barrier permeability in streptozocin-induced diabetic rats. Neuro. Lett. 188 (1995) 93-96
3. Belayev L., Busto R., Watson B.D., and Ginsberg M.D. Post-ischemic administration of HU-211, a novel non-competitive NMDA antagonist, protects against blood-brain barrier disruption in photochemical cortical infraction in rats: a quantitative study. Brain Res. 702 (1995) 266-270
4. Dan P., Yaron D., Dina M., and Rimona M. Fluoxetine inhibits multidrug resistance extrusion pumps and enhances responses to chemotherapy in syngeneic and in human xenograft mouse tumor models. Cancer Res. 64 (2004) 7562-7569
5. de Vries H.E., Kuiper J., Deboer A.G., Vanberkei T.J., and Breimer D.D. The blood-brain barrier in neuroinflammatory diseases. Pharmacol. Rev. 49 (1997) 143-155
6. Fontaine M., Elmquist W.F., and Miller D.W. Use of Rhodamine123 to examine the functional activity of P-glycoprotein in primary cultured brain microvessel endothelial cell monolayers. Life Sci. 59 (1996) 1521-1531
7. Fouyas I.P., Kelly P.A.T., Ritchie I.M., Lammie G.A., and Whittle I.R. Cerebrovascular responses to pathophysiological insult in diabetic rats. J. Clin. Neurosci. 10 (2003) 88-91
8. Gonzalez-Scarano F., and Baltuch G. Microglia as mediators of inflammatory and degenerative diseases. Annu. Rev. Neurosci. 22 (1999) 219-240
9. Guo P., Wang X.M., Zhou F., and Gallo J.M. Determination of vincristine in mouse plasma and brain tissues by liquid chromatography-electrospray mass spectrometry. J. Chromatogr., B, Biomed. Sci. Appl. 809 (2004) 273-278
10. Heidrun P., and Wolfgang L. In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats. Epilepsia 42 (2001) 1231-1240
11. Heidrun P., Maren F., and Wolfgang L. P-glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats. Neuro. Lett. 327 (2002) 173-176
12. Hiroyuki K., and Yuichi S. Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier. Drug Discov. Today 6 (2001) 150-156
13. Kamei J., Hirano S., Miyata S., Saito A., and Onodera K. Effects of first- and second-generation histamine-H1-receptor antagonists on the pentobarbital-induced loss of the righting reflex in streptozotocin-induced diabetic mice. J. Pharmacol. Sci. 97 (2005) 266-272
14. Liu X.D., Pan G.Y., Xie L., Hou Y.Y., Lan W., and Su J. P-glycoprotein inhibitor cyclosprin A enhanced the protection of nimodipine against brain damage induced by hypoxia-ischemia in mice and rats. Acta Pharmacol. Sin. 23 (2003) 225-229
15. Lorenzi M., Healy D.P., Hawkins R., Printz J.M., and Printz M.P. Studies on the permeability of the blood-brain barrier in experimental diabetes. Diabetologia 29 (1986) 58-62
16. Miles W.R., and Root H.F. Psychologic tests applied to diabetic patients. Arch. Int. Med. 30 (1992) 767-777
17. Mooradian A.D. Central nervous system complications of diabetes mellitus-a perspective from the blood-brain barrier. Brain Res. Rev. .23 (1997) 210-218
18. Ornoy A., Zaken V., Abir R., Yaffe P., and Raz I. Effects on rat embryos of culture in serum of women with gestational diabetes. Toxicol. In Vitro 9 (1995) 643-651
19. Schinkel A.H. P-glycoprotein, a gatekeeper in the blood-brain barrier. Adv. Drug Deliv. Rev. 36 (1999) 179-194
20. Stauber W.T., Oug S.H., and McCuskey R.S. Selective extravascular escape of albumin into the cerebral cortex of the diabetic rat. Diabetes 30 (1981) 500-503
21. Sun H.Y., Dai H.Q., Shaik N., and William F. Drug efflux transporters in the CNS. Adv. Drug Deliv. Rev. 55 (2003) 83-105
22. Sun J.J., Xie L., and Liu X.D. Transport of carbamazepine and drug interactions at the blood-brain barrier. Acta Pharmacol. Sin. 27 (2006) 249-253
23. Tarui S., Yamada K., and Hanafusa T. Animal models utilized in the research of diabetes mellitus-with special reference in insulin-associated diabetes. Prog. Clin. Biol. Res. 229 (1997) 211-223
24. Týmea B., Bernadett B., Balazs D., Imola S., and Karoly T. Insulin in flavin-containing monooxygenase regulation flavin-containing monooxygenase and cytochrome P450 activities in experimental diabetes. Eur. J. Pharm. Sci. 28 (2006) 51-58
25. Tishler D.M., Weinberg K.T., and Hinton D.R. MDR gene expression in brain of patients with medically intractable epilepsy. Epilepsia 36 (1995) 1-6
26. van Waarde W.M., Verkade H.J., Wolters H., Havinga R., Baller J., and Bloks V. Differential effects of streptozotocin-induced diabetes on expression of hepatic ABC-transporters in rats. Gastroenterology 122 (2005) 1842-1852
27. Vellonen K.S., Honkakoski P., and Urtti A. Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity. Eur. J. Pharm. Sci. 23 (2004) 181-188
28. Yoshiyuki H., Sachiko H., Noriyuki S., and Kikuo K. High-glucose-induced nuclear factor κB activation in vascular smooth muscle cells. Cardiovasc. Res. 46 (2000) 188-197
29. Zhang L., Liu X.D., Xin L., and Wang G.J. P-glycoprotein restricted transport of nimodipine across blood-brain barrier. Acta Pharmacol. Sin. 24 (2003) 903-906
30. Zhao Y.L., Du J., Kanazawa H., Sugawara A., Takagi K., and Kitaichi K. Effect of endotoxin on doxorubicin transport across blood-brain barrier and P-glycoprotein function in mice. Eur. J. Pharmacol. 445 (2002) 115-123
31. Zhou H.H., Tong Z., and James F.M. "Cocktail" approaches and strategies in drug development: valuable tool or flawed science?. J. Clin. Pharmacol. 44 (2004) 120-134
32. Zhu H.J., and Liu G.Q. Glutamate up-regulates P-glycoprotein expression in rat brain microvessel endothelial cells by an NMDA receptor-mediated mechanism. Life Sci. 75 (2004) 1313-1322