Association between MTHFR C677T and A1298C, and MTRR A66G polymorphisms and susceptibility to schizophrenia in a Syrian study cohort

Asian Journal of Psychiatry

Volumn 5, Issue 2, 2012, Pages 144-149

  Lajin, Bassam ^a   Alhaj Sakur, Amir ^a   Michati, Roula ^b   Alachkar, Amal ^a  

^a UNIVERSITY OF ALEPPO   (Syrian Arab Republic)

^b Ibn Khaldoon Psychiatric Hospital   (Syrian Arab Republic)

Author keywords

Folate homocysteine; MTHFR; MTRR; Polymorphisms; Schizophrenia

Indexed keywords

FOLIC ACID; HOMOCYSTEINE;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; FEMALE; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; SYRIAN ARAB REPUBLIC;

ADULT; ALLELES; COHORT STUDIES; FEMALE; FERREDOXIN-NADP REDUCTASE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, GENETIC; SCHIZOPHRENIA; SYRIA;

EID: 84862001854     PISSN: 18762018     EISSN: 18762026     Source Type: Journal    
DOI: 10.1016/j.ajp.2012.03.002     Document Type: Article

References (47)

1. Abdolmaleky H.M., Cheng K.H., et al. Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2005, 134B(1):60-66.
2. Allen N.C., Bagade S., et al. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nature Genetics 2008, 40(7):827-834.
3. Arinami T., Yamada N., et al. Methylenetetrahydrofolate reductase variant and schizophrenia/depression. American Journal of Medical Genetics 1997, 74(5):526-528.
4. Boyles A.L., Hammock P., et al. Candidate gene analysis in human neural tube defects. American Journal of Medical Genetics Part C: Seminars in Medical Genetics 2005, 135C(1):9-23.
5. Brattström L., Wilcken D.E.L., et al. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation 1998, 98(23):2520-2526.
6. Chen Z., Karaplis A.C., et al. Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition. Human Molecular Genetics 2001, 10(5):433-443.
7. Feng L.G., Song Z.W., et al. Association of plasma homocysteine and methylenetetrahydrofolate reductase C677T gene variant with schizophrenia: A Chinese Han population-based case-control study. Psychiatry Research 2009, 168(3):205-208.
8. Friedman G., Goldschmidt N., et al. A common mutation A1298C in human methylenetetrahydrofolate reductase gene: association with plasma total homocysteine and folate concentrations. The Journal of Nutrition 1999, 129(9):1656-1661.
9. Frosst P., Blom H.J., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nature Genetics 1995, 10(1):111-113.
10. Gaughan D.J., Kluijtmans L.A., et al. The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations. Atherosclerosis 2001, 157(2):451-456.
11. Gilbody S., Lewis S., et al. Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review. American Journal of Epidemiology 2007, 165(1):1-13.
12. Green R., Miller J.W. Folate deficiency beyond megaloblastic anemia: hyperhomocysteinemia and other manifestations of dysfunctional folate status. Seminars in Hematology 1999, 36(1):47-64.
13. Gudnason V., Stansbie D., et al. C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): its frequency and impact on plasma homocysteine concentration in different European populations. Atherosclerosis 1998, 136(2):347-354.
14. Gueant-Rodriguez R.M., Juilliere Y., et al. Association of MTRR A66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population. Thrombosis and Haemostasis 2005, 94(3):510-515.
15. Hustad S., Ueland P.M., et al. Riboflavin as a determinant of plasma total homocysteine: effect modification by the methylenetetrahydrofolate reductase C677T polymorphism. Clinical Chemistry 2000, 46(8 Pt 1):1065-1071.
16. Jacques P.F., Bostom A.G., et al. Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study. Atherosclerosis 2003, 166(1):49-55.
17. Jonsson E.G., Larsson K., et al. Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: an association study. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2008, 147B(6):976-982.
18. Joober R., Benkelfat C., et al. Association between the methylenetetrahydrofolate reductase 677C→T missense mutation and schizophrenia. Molecular Psychiatry 2000, 5(3):323-326.
19. Kempisty B., Mostowska A., et al. Association of 677C→T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene with bipolar disorder and schizophrenia. Neuroscience Letters 2006, 400(3):267-271.
20. Kempisty B., Bober A., et al. Distribution of 1298A→C polymorphism of methylenetetrahydrofolate reductase gene in patients with bipolar disorder and schizophrenia. European Psychiatry 2007, 22(1):39-43.
21. Kunugi H., Fukuda R., et al. C677T polymorphism in methylenetetrahydrofolate reductase gene and psychoses. Molecular Psychiatry 1998, 3(5):435-437.
22. Lajin B., Alachkar A., Alhaj Sakur A. Triplex Tetra-Primer ARMS-PCR Method for the Simultaneous Detection of MTHFR c.677C→T and c.1298A→C, and MTRR c.66A→G Polymorphisms of the folate-homocysteine metabolic pathway. Molecular and Cellular Probes 2011, 26(1):16-20.
23. Laraqui A., Allami A., et al. Influence of methionine synthase (A2756G) and methionine synthase reductase (A66G) polymorphisms on plasma homocysteine levels and relation to risk of coronary artery disease. Acta Cardiologica 2006, 61(1):51-61.
24. Lewis S.J., Zammit S., et al. A meta-analysis of the MTHFR C677T polymorphism and schizophrenia risk. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2005, 135B(1):2-4.
25. Muntjewerff J.W., Blom H.J. Aberrant folate status in schizophrenic patients: what is the evidence?. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2005, 29(7):1133-1139.
26. Muntjewerff J.W., Hoogendoorn M.L., et al. Hyperhomocysteinemia, methylenetetrahydrofolate reductase 677TT genotype, and the risk for schizophrenia: a Dutch population based case-control study. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2005, 135B(1):69-72.
27. Muntjewerff J.W., Kahn R.S., et al. Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis. Molecular Psychiatry 2006, 11(2):143-149.
28. Olteanu H., et al. Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase. Biochemistry (Moscow) 2002, 41:13378-13385.
29. Olteanu H., Munson T., et al. Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase. Biochemistry 2002, 41(45):13378-13385.
30. Refsum H., Smith A.D., et al. Facts and recommendations about total homocysteine determinations: an expert opinion. Clinical Chemistry 2004, 50(1):3-32.
31. Regland B., Johansson B.V., et al. Homocysteinemia and schizophrenia as a case of methylation deficiency. Journal of Neural Transmission General Section 1994, 98(2):143-152.
32. Saetre P., Vares M., et al. Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and age of onset in schizophrenia: a combined analysis of independent samples. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2011, 156(2):215-224.
33. Sazci A., Ergul E., et al. Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene with schizophrenia: association is significant in men but not in women. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2005, 29(7):1113-1123.
34. Shi J., Gershon E.S., et al. Genetic associations with schizophrenia: meta-analyses of 12 candidate genes. Schizophrenia Research 2008, 104(1-3):96-107.
35. Slatkin M., Excoffier L. Testing for linkage disequilibrium in genotypic data using the EM algorithm. Heredity 1996, 76:377-383.
36. Szvetko A.L., Fowdar J., et al. No association between MTHFR A1298C and MTRR A66G polymorphisms, and MS in an Australian cohort. Journal of the Neurological Sciences 2007, 252(1):49-52.
37. Tan E.C., Chong S.A., et al. Genetic analysis of the thermolabile methylenetetrahydrofolate reductase variant in schizophrenia and mood disorders. Psychiatric Genetics 2004, 14(4):227-231.
38. Ueland P.M., Hustad S., et al. Biological and clinical implications of the MTHFR C677T polymorphism. Trends in Pharmacological Sciences 2001, 22(4):195-201.
39. Urreizti R., Moya-Garcia A.A., et al. Molecular characterization of five patients with homocystinuria due to severe methylenetetrahydrofolate reductase deficiency. Clinical Genetics 2010, 78(5):441-448.
40. van der Put N.M., Gabreels F., et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?. American Journal of Human Genetics 1998, 62(5):1044-1051.
41. Vares M., Saetre P., et al. Association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age of onset in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2010, 153B(2):610-618.
42. Vilella E., Virgos C., et al. Further evidence that hyperhomocysteinemia and methylenetetrahydrofolate reductase C677T and A1289C polymorphisms are not risk factors for schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2005, 29(7):1169-1174.
43. Virgos C., Martorell L., et al. Plasma homocysteine and the methylenetetrahydrofolate reductase C677T gene variant: lack of association with schizophrenia. Neuroreport 1999, 10(10):2035-2038.
44. Yoo J., Seo B. SNPAnalyzer: a web-based integrated workbench for single-nucleotide polymorphism analysis. Nucleic Acids Research 2005, 33(Suppl. 2):W483-W488.
45. Yu L., Li T., et al. No association between polymorphisms of methylenetetrahydrofolate reductase gene and schizophrenia in both Chinese and Scottish populations. Molecular Psychiatry 2004, 9(12):1063-1065.
46. Zintzaras E. C677T and A1298C methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, bipolar disorder and depression: a meta-analysis of genetic association studies. Psychiatric Genetics 2006, 16(3):105-115.
47. Zintzaras E., Koufakis T., et al. A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia. European Journal of Epidemiology 2006, 21(7):501-510.