The nature of nutrition: A unifying framework

Australian Journal of Zoology

Volumn 59, Issue 6, 2011, Pages 350-368

  Simpson, Stephen J ^a   Raubenheimer, David ^b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b MASSEY UNIVERSITY   (New Zealand)

Author keywords

Ageing; cannibalism; conservation; Geometric Framework.

Indexed keywords

AGING; ANIMAL; CANNIBALISM; ECOSYSTEM STRUCTURE; FITNESS; FOOD WEB; GRAPHICAL METHOD; GROUP BEHAVIOR; NUTRITION; NUTRITIONAL REQUIREMENT; NUTRITIVE VALUE; PHYSIOLOGY;

ANIMALIA;

EID: 84861998695     PISSN: 0004959X     EISSN: None     Source Type: Journal    
DOI: 10.1071/ZO11068     Document Type: Conference Paper

References (197)

1. Abisgold, J. D., Simpson, S. J., and Douglas, A. E. (1994). Nutrient regulation in the pea aphid Acyrthosiphon pisum: Application of a novel geometric framework to sugar and amino acid consumption. Physiological Entomology 19, 95-102. doi:10.1111/j.1365-3032.1994.tb01081.x (Pubitemid 2095605)
2. Altmann, J., Schoeller, D., Altmann, S. A., Muruthi, P., and Sapolsky, R. M. (1993). Body size and fatness of free-living baboons reflect food availability and activity levels. American Journal of Primatology 30, 149-161. doi:10.1002/ajp.1350300207
3. Andrew, R., Wallis, I. R., Harwood, C. E., Henson, M., and Foley, W. J. (2007). Heritable variation in the foliar secondary metabolite sideroxylonal in Eucalyptus confers cross-resistance to herbivores. Oecologia 153, 891-901. doi:10.1007/s00442-007-0784-1 (Pubitemid 47389319)
4. Angilletta, M. J. (2009). 'Thermal Adaptation: A Theoretical and Empirical Synthesis.' (Oxford University Press: Oxford.)
5. Archer, C. R., Royle, N., South, S., Selman, C., and Hunt, J. (2009). Nutritional geometry provides food for thought. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 64A, 956-959. doi:10.1093/gerona/glp069
6. Aubert, A., Goodall, G., and Dantzer, R. (1995). Compared effects of cold ambient temperature and cytokines on macronutrient intake in rats. Physiology & Behavior 57, 869-873. doi:10.1016/0031-9384(94) 00391-H
7. Barker, D. J. P. (1998), 'Mothers, Babies and Health in Later Life.' 2nd edn. (Churchill Livingstone: London.)
8. Barton Browne, L. (1995). Ontogenetic changes in feeding behavior. In 'Regulatory Mechanisms in Insect Feeding'. (Eds R. F. Chapman and G. de Boer.) pp. 307-342. (Chapman and Hall: New York.)
9. Bazazi, S., Buhl, J., Hale, J. J., Anstey,M.L., Sword, G. A., Simpson, S. J., and Couzin, I. D. (2008). Collective motion and cannibalism in locust migratory bands. Current Biology 18, 735-739. doi:10.1016/j.cub.2008. 04.035
10. Bazazi, S., Romanczuk, P., Thomas, S., Schimansky-Geier, L., Hale, J. J., Miller, G. A., Sword, G. A., Simpson, S. J., and Couzin, I. D. (2011). Nutritional state and collective motion: From individuals to mass migration. Proceedings. Biological Sciences 278, 356-363. doi:10.1098/rspb.2010.1447
11. Behmer, S. T. (2009). Insect herbivore nutrient regulation. Annual Review of Entomology 54, 165-187. doi:10.1146/annurev.ento.54. 110807.090537
12. Behmer, S. T., Simpson, S. J., and Raubenheimer, D. (2002). Herbivore foraging strategies in chemically heterogeneous environments: Allelochemical-nutrient interactions. Ecology 83, 2489-2501. doi:10.1890/0012-9658(2002)083[2489:HFICHE]2.0.CO;2 (Pubitemid 36524734)
13. Berenbaum, M. R. (1995). Turnabout is fair play: Secondary roles for primary compounds. Journal of Chemical Ecology 21, 925-940. doi:10.1007/ BF02033799
14. Bernays, E. A. (1993). Food aversion learning. In 'Insect Learning'. (Eds A. C. Lewis and D. Papaj.) pp. 1-17. (Chapman and Hall: New York.)
15. Boersma, M., and Elser, J. J. (2006). Too much of a good thing: On stoichiometrically balanced diets and maximal growth. Ecology 87, 1325-1330. doi:10.1890/0012-9658(2006)87[1325:TMOAGT]2.0. CO;2
16. Booth, D. A., and Thibault, L. (2000). Macronutrient-specific hungers and satieties and their neural bases, learnt from pre- and postingestinal effects of eating particular foodstuffs. In 'Neural and Metabolic Control of Macronutrient Intake'. (Eds H.-R. Berthoud and R. J. Seeley.) pp. 61-91. (CRC Press: Boca Raton, FL.)
17. Burke, C. J., and Waddell, S. (2011). Remembering nutrient quality of sugar in Drosophila. Current Biology 21, 746-750. doi:10.1016/j.cub.2011. 03.032
18. Calabrese, E. J. (2005). Paradigm lost, paradigm found: The re-emergence of hormesis as a fundamental dose response model in the toxicological sciences. Environmental Pollution 138, 379-412. doi:10.1016/j.envpol. 2004.10.001 (Pubitemid 41140395)
19. Calabrese, E. J., and Baldwin, L. A. (2003). Toxicology rethinks its central belief - hormesis demands a reappraisal of the way risks are assessed. Nature 421, 691-692. doi:10.1038/421691a (Pubitemid 36227604)
20. Calabrese, E. J., Baldwin, L. A., and Holland, C. D. (1999). Hormesis: A highly generalizable and reproducible phenomenon with important implications for risk assessment. Risk Analysis 19, 261-281. doi:10.1111/j.1539-6924.1999. tb00404.x (Pubitemid 29374651)
21. Carey, J. R., Harshman, L. G., Liedo, P., Müller, H.-G., Wang, J.-L., and Zhang, Z. (2008). Longevity-fertility trade-offs in the tephritid fruit fly, Anastrepha ludens, across dietary-restriction gradients. Aging Cell 7, 470-477. doi:10.1111/j.1474-9726.2008.00389.x (Pubitemid 351998607)
22. Carleton, A., Accolla, R., and Simon, S. A. (2010). Coding in the mammalian gustatory system. Trends in Neurosciences 33, 326-334. doi:10.1016/j.tins.2010.04.002
23. Cassill, D. L., and Tschinkel, W. R. (1999). Regulation of diet in the fire ant, Solenopsis invicta. Journal of Insect Behavior 12, 307-328. doi:10.1023/A:1020835304713 (Pubitemid 29347830)
24. Chambers, P. G., Simpson, S. J., and Raubenheimer, D. (1995). Behavioural mechanisms of nutrient balancing in Locusta migratoria. Animal Behaviour 50, 1513-1523. doi:10.1016/0003-3472(95)80007-7 (Pubitemid 3008404)
25. Chambers, P. G., Simpson, S. J., and Raubenheimer, D. (1997). The functional significance of switching interval in food mixing by Locusta migratoria. Journal of Insect Physiology 44, 77-85. doi:10.1016/S0022-1910(97) 00085-1 (Pubitemid 28087226)
26. Clissold, F. J., Tedder, B. J., Conigrave,A. D., and Simpson, S. J. (2010). The gastrointestinal tract as a nutrient balancing organ. Proceedings. Biological Sciences 277, 1751-1759. doi:10.1098/rspb.2009.2045
27. Coggan, N., Clissold, F. J., and Simpson, S. J. (2011). Locusts use dynamic thermoregulatory behaviour to optimise nutritional outcomes. Proceedings. Biological Sciences 278, 2745-2752. doi:10.1098/rspb. 2010.2675
28. Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., and Weindruch, R. (2009). Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325, 201-204. doi:10.1126/science.1173635
29. Cook, S. C., Eubanks, M. D., Gold, R. E., and Behmer, S. T. (2010). Colony-level macronutrient regulation in ants: Mechanisms, hoarding and associated costs. Animal Behaviour 79, 429-437. doi:10.1016/j.anbehav.2009.11. 022
30. Cota, D., Proulx, K., and Seeley, R. J. (2007). The role of CNS fuel sensing in energy and glucose regulation. Gastroenterology 132, 2158-2168. doi:10.1053/j.gastro.2007.03.049 (Pubitemid 46693748)
31. Cotter, S. C., Simpson, S. J., Raubenheimer, D., and Wilson, K. (2011). Macronutrient balance mediates trade-offs between immune function and life history traits. Functional Ecology 25, 186-198. doi:10.1111/j.1365-2435.2010. 01766.x
32. Crespi, E. J., and Denver, R. J. (2006). Leptin (ob gene) of the South African clawed frog Xenopus laevis. Proceedings of the National Academy of Sciences of the United States of America 103, 10 092-10 097. doi:10.1073/pnas.0507519103 (Pubitemid 43993628)
33. Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., Kolodny, G. M., and Kahn, C. R. (2009). Identification and importance of brown adipose tissue in adult humans. The New England Journal of Medicine 360, 1509-1517. doi:10.1056/NEJMoa0810780
34. De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccinie, G., and Lionetti, P. (2010). Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proceedings of the National Academy of Sciences of the United States of America 107, 14 691-14 696. doi:10.1073/pnas.1005963107
35. DeAngelis, D. L., Mulholland, P. J., Palumbo, A. V., Steinmen, A. D., Huston, M. A., and Elwood, J. W. (1989). Nutrient dynamics and food-web stability. Annual Review of Ecology and Systematics 20, 71-95. doi:10.1146/annurev.es.20.110189.000443
36. Dearing, M. D., Forbey, J. S., McLister, J. D., and Santos, L. (2008). Ambient temperature influences diet selection and physiology of an herbivorous mammal, Neotoma albigula. Physiological and Biochemical Zoology 81, 891-897. doi:10.1086/588490
37. Denno, R. F., and Fagan, W. F. (2003). Might nitrogen limitation promote omnivory among carnivorous arthropods? Ecology 84, 2522-2531. doi:10.1890/02-0370 (Pubitemid 38261143)
38. Dethier, V. G. (1976). 'The Hungry Fly.' (Princeton University Press: Princeton, NJ.)
39. Dong, D., Jones, G., and Zhang, S. (2009). Dynamic evolution of bitter taste receptor genes in vertebrates. BMC Evolutionary Biology 9, 1-9. doi:10.1186/1471-2148-9-12
40. Douglas, A. E. (2010). 'The Symbiotic Habit.' (Princeton University Press: Princeton, NJ.)
41. Dukas, R. (2008). Evolutionary biology of insect learning. Annual Review of Entomology 53, 145-160. doi:10.1146/annurev.ento.53.103106. 093343 (Pubitemid 351341935)
42. Dussutour, A., and Simpson, S. J. (2008). Carbohydrate regulation in relation to colony growth in ants. The Journal of Experimental Biology 211, 2224-2232. doi:10.1242/jeb.017509
43. Dussutour, A., and Simpson,S. J. (2009).Communalnutrition in ants. Current Biology 19, 740-744. doi:10.1016/j.cub.2009.03.015
44. Everitt, A. V., Rattan, S., Le Couteur, D., and de Cabo, R. (Eds) 2010). 'Calorie Restriction, Aging, and Longevity.' Springer: Dordrecht.)
45. Fagan, W. F., and Denno, R. F. (2004). Stoichiometry of actual vs. potential predator-prey interactions: Insights into nitrogen limitation for arthropod predators. Ecology Letters 7, 876-883. doi:10.1111/j.1461-0248.2004. 00641.x (Pubitemid 39175200)
46. Fanson, B. G., and Taylor, P. W. (2011). Protein: Carbohydrate ratios explain lifespan patterns found in Queensland fruit fly on diets varying in yeast : Sugar ratios. Age. doi:10.1007/s11357-011-9308-3
47. Fanson, B. G., Weldon, C. W., Pérez-Staples, D., Simpson, S. J., and Taylor, P. W. (2009). Nutrients, not caloric restriction, extend lifespan in Queensland fruit flies (Bactrocera tryoni). Aging Cell 8, 514-523. doi:10.1111/j.1474-9726.2009.00497.x
48. Felton, A. M., Felton, A., Raubenheimer, D., Simpson, S. J., Foley, W. J., Wood, J. T., Wallis, I. R., and Lindenmayer, D. B. (2009a). Protein content of diets dictates the daily energy intake of a free-ranging primate. Behavioral Ecology 20, 685-690. doi:10.1093/beheco/arp021
49. Felton, A. M., Felton, A., Wood,J. T., Foley,W.J., Raubenheimer, D., Wallis, I. R., and Lindenmayer, D. B. (2009b). Nutritional ecology of Ateles chamek in lowland Bolivia: How macronutrient balancing influences food choices. International Journal of Primatology 30, 675-696. doi:10.1007/s10764-009-9367-9
50. Finger, T. E. (1997). Evolution of taste and solitary chemoreceptor cell systems. Brain, Behavior and Evolution 50, 234-243. doi:10.1159/000113337 (Pubitemid 127467465)
51. Flatt, T. (2011). Survival costs of reproduction in Drosophila. Experimental Gerontology 46, 369-375. doi:10.1016/j.exger.2010.10.008
52. Fujita, M., and Tanimura, T. (2011). Drosophila evaluates and learns the nutritional value of sugars. Current Biology 21, 751-755. doi:10.1016/j.cub. 2011.03.058
53. Galef, B. G. Jr. and Laland, K. N. (2005). Social learning in animals: Empirical studies and theoretical models. Bioscience 55, 489-499. doi:10.1641/0006-3568(2005)055[0489:SLIAES]2.0.CO;2 (Pubitemid 40748383)
54. Gluckman, P. D., and Hanson, M. A. (2004). The developmental origins of the metabolic syndrome. Trends in Endocrinology and Metabolism 15, 183-187. doi:10.1016/j.tem.2004.03.002 (Pubitemid 38510499)
55. Gluckman, P. D., and Hanson, M. A. (Eds) (2006a). 'Developmental Origins of Health and Disease.' (Cambridge University Press: Cambridge.)
56. Gluckman, P. D., and Hanson, M. A. (2006b). 'Mismatch: Why Our World No Longer Fits Our Bodies.' (Oxford University Press: Oxford.)
57. Gluckman, P. D., Hanson, M. A., Bateson, P., Beedle, A. S., Law, C. M., Bhutta, Z. A., Anokhin, K. V., Bougnères, P., Chandak, G. R., Dasgupta, P., Smith, G. D., Ellison, P. T., Forrester, T., Gilbert, S. F., Jablonka, E., Kaplan, H., Prentice, A. M., Simpson, S. J., Uauy, R., and West-Eberhard, M. J. (2009). Towards a new developmental synthesis: Adaptive developmental plasticity and human disease. Lancet 373, 1654-1657. doi:10.1016/S0140-6736(09)60234-8
58. Gosby, A. K., Conigrave, A. D., Lau, N. S., Iglesias, M. A., Hall, R. M., Jebb, S. A., Brand-Miller, J., Caterson, I. D., Raubenheimer, D., and Simpson, S. J. (2011). Testing protein leverage in lean humans: A randomised controlled experimental study. PLoS ONE 6, e25929. doi:10.1371/journal.pone.0025929
59. Grandison, R. C., Piper, M. D. W., and Partridge, L. (2009). Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature 462, 1061-1064. doi:10.1038/nature08619
60. Grimm, V., and Railsback, S. F. (2005). 'Individual-based Modeling and Ecology.' (Princeton University Press: Princeton, NJ.)
61. Hansen, B. C. (2001). Causes of obesity and consequences of obesity prevention in non-human primates and other animals. In 'International Textbook of Obesity'. (Ed. P. Björntorp.) pp. 181-201. (John Wiley and Sons: Chichester, UK.)
62. Hansen, M. J., Buhl, J., Bazazi, S., Simpson, S. J., and Sword, G. A. (2011). Cannibalism in the lifeboat - Collective movement in Australian plague locusts. Behavioral Ecology and Sociobiology 65, 1715-1720. doi:10.1007/s00265- 011-1179-1
63. Hawlena, D., and Schmitz, O. J. (2010). Herbivore physiological response to predation risk and implications for ecosystem nutrient dynamics. Proceedings of the National Academy of Sciences of the United States of America 107, 15503-15507. doi:10.1073/pnas.1009300107
64. Hayes, D. P. (2007). Nutritional hormesis. European Journal of Clinical Nutrition 61, 147-159. doi:10.1038/sj.ejcn.1602507
65. Hewson-Hughes, A. K., Hewson-Hughes, V. L., Miller, A. T., Hall, S. R., Simpson, S. J., and Raubenheimer, D. (2011). Geometric analysis of macronutrient selection in the adult domestic cat, Felis catus. The Journal of Experimental Biology 214, 1039-1051. doi:10.1242/jeb. 049429
66. Hölldobler, B., and Wilson, E. O. (2009). 'The Superorganism: The Beauty, Elegance, and Strangeness of Insect Societies.' (W.W. Norton & Co.: New York.)
67. Houston, A., and Sumida, B. (1985).Apositive feedback model for switching between two activities. Animal Behaviour 33, 315-325. doi:10.1016/S0003- 3472(85)80145-7
68. Huffman, M. A. (2001). Self-medicative behavior in the African great apes: An evolutionary perspective into the origins of human traditional medicine. Bioscience 51, 651-661. doi:10.1641/0006-3568(2001)051 [0651:SMBITA]2.0.CO;2 (Pubitemid 32792833)
69. Huffman, M. A. (2003). Animal self-medication and ethno-medicine: Exploration and exploitation of the medicinal properties of plants. The Proceedings of the Nutrition Society 62, 371-381. doi:10.1079/PNS2003257 (Pubitemid 36841611)
70. Hunt, J. H., and Nalepa, C. A. (Eds) (1994). 'Nourishment and Evolution in Insect Societies.' (Westview Press: Boulder, CO.)
71. Hutchings, M. R., Athanasiadou, S., Kyriazakis, I., and Gordon, I. J. (2003). Cananimals use foraging behaviour to combat parasites? The Proceedings of the Nutrition Society 62, 361-370. doi:10.1079/PNS2003243 (Pubitemid 36841610)
72. Hutchinson, G. E. (1957). Concluding remarks. Cold Spring Harbor Symposia on Quantitative Biology 22, 415-427. doi:10.1101/SQB.1957. 022.01.039
73. Ja, W. W., Carvalho,G. B., Zid, B. M., Mak, E. M., Brummel, T., and Benzer, S. (2009). Water- and nutrient-dependent effects of dietary restriction on Drosophila lifespan. Proceedings of the National Academy of Sciences of the United States of America 106, 18 633-18 637. doi:10.1073/pnas. 0908016106
74. Jensen, K., Mayntz, D., Tøft, S., Raubenheimer, D., and Simpson, S. J. (2011). Nutrient regulation in a predator, the wolf spider Pardosa prativaga. Animal Behaviour 81, 993-999. doi:10.1016/j.anbehav.2011.01.035
75. Jensen, K., Mayntz, D., Tøft, S., Clissold, F. J., Hunt, J., Raubenheimer, D., and Simpson, S. J. (2012). Optimal foraging for specific nutrients in predatory beetles. Proceedings of the Royal Society B: Biological Sciences. doi:10.1098/rspb.2011.2410
76. Kamakura,M.(2011). Royalactin induces queen differentiation in honeybees. Nature 473, 478-483. doi:10.1038/nature10093
77. Karban, R., and Baldwin, I. T. (1997). 'Induced Responses to Herbivory.' (University of Chicago Press: Chicago, IL.)
78. Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., and Gordon, J I (2011). Human nutrition, the gut microbiome and the immune system. Nature 474, 327-336. doi:10.1038/nature10213
79. Kearney, M. (2006). Habitat, environment and niche: What are we modelling? Oikos 115, 186-191. doi:10.1111/j.2006.0030-1299.14908.x (Pubitemid 44521332)
80. Kearney, M., and Porter, W. P. (2009). Mechanistic niche modelling: Combining physiological and spatial data to predict species' ranges. Ecology Letters 12, 334-350. doi:10.1111/j.1461-0248.2008.01277.x
81. Kearney, M., Simpson, S. J., Raubenheimer, D., and Helmuth, B. (2010). Modelling the ecological niche from functional traits. Philosophical Transactions of the Royal Society B. Biological Sciences 365, 3469-3483. doi:10.1098/rstb.2010.0034
82. Kirkwood, T. B. L. (2005). Understanding the odd science of aging. Cell 120, 437-447. doi:10.1016/j.cell.2005.01.027 (Pubitemid 40269759)
83. Kooijman, S. A. L.M.(2009). 'DynamicEnergy Budget Theory for Metabolic Organisation.' (Cambridge University Press: Cambridge.)
84. Kuijper, L. D. J., Anderson, T. R., and Kooijman, S. A. L. M. (2004). C andN gross growth efficiencies of copepod egg production studied using a dynamic energy budget model. Journal of Plankton Research 26, 213-226. doi:10.1093/plankt/fbh020 (Pubitemid 38260835)
85. Kytö, M., Niemelä, P., and Larsson, S. (1996). Insects on trees: Population and individual response to fertilization. Oikos 75, 148-159. doi:10.2307/3546238
86. Le Rohellec, M., and Le Bourg, É. (2009). Contrasted effects of suppressing live yeast from food on longevity, aging and resistance to several stresses in Drosophila melanogaster. Experimental Gerontology 44, 695-707. doi:10.1016/j.exger.2009.08.001
87. Lee, K. P., Behmer, S. T., Simpson, S. J., and Raubenheimer, D. (2002). A geometric analysis of nutrient regulation in the generalist caterpillar Spodoptera littoralis (Boisduval). Journal of Insect Physiology 48, 655-665. doi:10.1016/S0022-1910(02)00088-4 (Pubitemid 34855663)
88. Lee, K. P., Raubenheimer, D., and Simpson, S. J. (2003). A correlation between nutrient balancing and insect host-plant range: Evidence from the specialist caterpillar Spodoptera exempta. Journal of Insect Physiology 49, 1161-1171. doi:10.1016/j.jinsphys.2003.08.013 (Pubitemid 37519212)
89. Lee, K. P., Simpson, S. J., and Raubenheimer, D. (2004). A comparison of nutrient regulation between solitarious and gregarious phases of the specialist caterpillar, Spodoptera exempta (Walker). Journal of Insect Physiology 50, 1171-1180. doi:10.1016/j.jinsphys.2004.10.009
90. Lee, K. P., Cory, J. S., Wilson, K., Raubenheimer, D., and Simpson, S. J. (2006a). Flexible diet choice offsets protein costs of pathogen resistance in a caterpillar. Proceedings. Biological Sciences 273, 823-829. doi:10.1098/rspb.2005.3385 (Pubitemid 46780855)
91. Lee, K. P., Behmer, S. T., and Simpson, S. J. (2006b). Nutrient regulation in relation to diet breadth: A comparison of Heliothis sister species and a hybrid. The Journal of Experimental Biology 209, 2076-2084. doi:10.1242/jeb.02253 (Pubitemid 43987884)
92. Lee, K. P., Simpson, S. J., Clissold, F. J., Brooks, R., Ballard, J. W. O., Taylor, P. W., Soran, N., and Raubenheimer, D. (2008a). Lifespan and reproduction in Drosophila: New insights from nutritional geometry. Proceedings of the National Academy of Sciences of the United States of America 105, 2498-2503. doi:10.1073/pnas.0710787105 (Pubitemid 351520542)
93. Lee, K. P., Simpson, S. J., and Wilson, K. (2008b). Dietary protein-quality influences melanization and immune function in an insect. Functional Ecology 22, 1052-1061. doi:10.1111/j.1365-2435.2008.01459.x
94. Leibowitz, S. F., Lucas, D. J., Leibowitz, K. L., and Jhanwar, Y. S. (1991). Developmental patterns of macronutrient intake in female and male rats from weaning to maturity. Physiology & Behavior 50, 1167-1174. doi:10.1016/0031-9384(91)90578-C
95. Lorch, P. D., Sword, G. A., Gwynne, D. T., and Anderson, G. L. (2005). Radiotelemetry reveals differences in individual movement patterns between outbreak and non-outbreak Mormon cricket populations. Ecological Entomology 30, 548-555. doi:10.1111/j.0307-6946.2005. 00725.x (Pubitemid 43906581)
96. Lozano, G. A. (1998). Parasitic stress and self-medication. Advances in the Study of Behavior 27, 291-317. doi:10.1016/S0065-3454(08) 60367-8
97. Luckey, T. D., and Stone, P. C. (1960). Hormology in nutrition. Science 132, 1891-1893. doi:10.1126/science.132.3443.1891
98. Mair, W., Piper, M. D. W., and Partridge, L. (2005). Calories do not explain extension of life span by dietary restriction in Drosophila. PLoS Biology 3, e223. doi:10.1371/journal.pbio.0030223 (Pubitemid 41032198)
99. Maklakov, A. A., Simpson, S. J., Zajitschek, F., Hall, M. D., Dessmann, J., Clissold, F., Raubenheimer, D., Bonduriansky, R., and Brooks, R. C. (2008). Sex-specific fitness effects of nutrient intake on reproduction and lifespan. Current Biology 18, 1062-1066. doi:10.1016/j.cub.2008. 06.059
100. Masoro, E. J. (2005). Overview of caloric restriction and ageing. Mechanisms of Ageing and Development 126, 913-922. doi:10.1016/j.mad.2005. 03.012 (Pubitemid 41033171)
101. Mayntz, D., Raubenheimer, D., Salomon, M., Tøft, S., and Simpson, S. J. (2005). Nutrient-specific foraging in invertebrate predators. Science 307, 111-113. doi:10.1126/science.1105493 (Pubitemid 40093490)
102. Mayntz, D., Nielsen, V. H., Sørensen, A., Tøft, S., Raubenheimer, D., Hejlesen, C., and Simpson, S. J. (2009). Balancing of protein and lipid intake by a mammalian carnivore, the mink, Mustela vison. Animal Behaviour 77, 349-355. doi:10.1016/j.anbehav.2008.09.036
103. McCay, C. M., Crowell, M. F., and Maynard, L. A. (1935). The effect of retarded growth upon the length of life and upon ultimate size. Journal of Nutrition 10, 63-79.
104. McMillen, C., and Robinson, J. S. (2005). Developmental origins of the metabolic syndrome: Prediction, plasticity, and programming. Physiological Reviews 85, 571-633. doi:10.1152/physrev.00053.2003 (Pubitemid 40404637)
105. Mertz, W. (1981). The essential trace elements. Science 213, 1332-1338. doi:10.1126/science.7022654 (Pubitemid 12243630)
106. Miller, R. A., Buehner, G., Chang, Y., Harper, J. M., Sigler, R., and Smith-Wheelock, M. (2005). Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell 4, 119-125. doi:10.1111/j.1474-9726.2005.00152.x (Pubitemid 41602745)
107. Miller, G. A., Clissold, F. J., Mayntz, D., and Simpson, S. J. (2009). Speed over efficiency: Locusts select body temperatures that favour growth rate over efficient nutrient utilization. Proceedings. Biological Sciences 276, 3581-3589. doi:10.1098/rspb.2009.1030
108. Morton, G. J., and Schwartz, M. W. (2011). Leptin and the central nervous system control of glucose metabolism. Physiological Reviews 91, 389-411. doi:10.1152/physrev.00007.2010
109. Musten, B., Peace, D., and Anderson, G. H. (1974). Food intake regulation in the weanling rat: Self-selection of protein and energy. The Journal of Nutrition 104, 563-572.
110. Newland, P. L., and Yates, P. (2008). Nitric oxide modulates salt and sugar responses via different signaling pathways. Chemical Senses 33, 347-356. doi:10.1093/chemse/bjm094 (Pubitemid 351676372)
111. Ng, S.-F., Lin, R. C. Y., Laybutt, D. R., Barres, R., Owens, J. A., and Morris, M. J. (2010). Chronic high-fat diet in fathers programs b-cell dysfunction in female rat offsrping. Nature 467, 963-966. doi:10.1038/ nature09491
112. Nonaka, E., and Holme, P. (2007). Agent-based model approach to optimal foraging in heterogeneous landscapes: Effects of patch clumpiness. Ecography 30, 777-788. doi:10.1111/j.2007.0906-7590.05148.x (Pubitemid 350292418)
113. O'Brien, D. M., Min, K.-J., Larsen, T., and Tatar, M. (2008). Use of stable isotopes to examine how dietary restriction extends Drosophila lifespan. Current Biology 18, R155-R156. doi:10.1016/j.cub.2008.01.021 (Pubitemid 351265395)
114. Oom, S. P., Beecham, J. A., Legg, C. J., and Hester, A. J. (2004). Foraging in a complex environment: From foraging strategies to emergent spatial properties. Ecological Complexity 1, 299-327. doi:10.1016/j.ecocom. 2004.06.003 (Pubitemid 41150838)
115. Orentreich, N., Matias, J. R., DeFelice, A., and Zimmerman, J. A. (1993). Low methionine ingestion by rats extends life span. The Journal of Nutrition 123, 269-274. (Pubitemid 23063011)
116. Peck, M. D., Babcock, G. F., and Alexander, J. W. (1992). The role of protein and calorie restriction in outcome from Salmonella infection in mice. Journal of Parenteral and Enteral Nutrition 16, 561-565. doi:10.1177/ 0148607192016006561
117. Pincebourde, S., and Casas, J. (2006). Multitrophic biophysical budgets: Thermal ecology of an intimate herbivore insect plant interaction. Ecological Monographs 76, 175-194. doi:10.1890/0012-9615(2006)076 [0175:MBBTEO]2.0.CO;2
118. Pirk, C. W. W., Boodhoo, C., Human, H., and Nicolson, S. W. (2010). The importance of protein type and protein to carbohydrate ratio for survival and ovarian activation of caged honeybees (Apis mellifera scutellata). Apidologie 41, 62-72. doi:10.1051/apido/2009055
119. Ponton, F., Lalubin, F., Fromont, C., Wilson, K., Behm, C., and Simpson, S. J. (2011a). Hosts use altered macronutrient intake to circumvent parasiteinduced reduction in fecundity. International Journal for Parasitology 41, 43-50. doi:10.1016/j.ijpara.2010.06.007
120. Ponton, F., Wilson, K., Cotter, S. C., Raubenheimer, D., and Simpson, S. J. (2011b). Nutritional immunology: A multi-dimensional approach. PLoS Pathogens 7, e1002223. doi:10.1371/journal.ppat.1002223
121. Porter, W. P., and Gates, D. M. (1969). Thermodynamic equilibria of animals with environment. Ecological Monographs 39, 227-244. doi:10.2307/1948545
122. Povey, S., Cotter, S. C., Simpson, S. J., Lee, K. P., and Wilson, K. (2009). Can the protein costs of bacterial resistance be offset by altered feeding behaviour? Journal of Animal Ecology 78, 437-446. doi:10.1111/j.1365- 2656.2008.01499.x
123. Raubenheimer, D., and Bassil, K. (2007). Separate effects of macronutrient concentration and balance on plastic gut responses in locusts. Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology 177, 849-855. doi:10.1007/s00360-007-0180-5 (Pubitemid 47632218)
124. Raubenheimer, D., and Jones, S. A. (2006). Nutritional imbalance in an extreme generalist omnivore: Tolerance and recovery through complementary food selection. Animal Behaviour 71, 1253-1262. doi:10.1016/j.anbehav.2005.07.024 (Pubitemid 43867477)
125. Raubenheimer, D., and Simpson, S. J. (1992). Analysis of covariance: An alternative to nutritional indices. Entomologia Experimentalis et Applicata 62, 221-231. doi:10.1111/j.1570-7458.1992.tb00662.x (Pubitemid 23400185)
126. Raubenheimer, D., and Simpson, S. J. (1993). The geometry of compensatory feeding in the locust. Animal Behaviour 45, 953-964. doi:10.1006/anbe.1993.1114
127. Raubenheimer, D., and Simpson, S. J. (1994). The analysis of nutrient budgets. Functional Ecology 8, 783-791. doi:10.2307/2390238
128. Raubenheimer, D., and Simpson, S. J. (1995). Constructing nutrient budgets. Entomologia Experimentalis et Applicata 77, 99-104. doi:10.1111/j.1570-7458.1995.tb01990.x
129. Raubenheimer, D., and Simpson, S. J. (1999). Integrating nutrition: A geometrical approach. Entomologia Experimentalis et Applicata 91, 67-82. doi:10.1046/j.1570-7458.1999.00467.x (Pubitemid 29416986)
130. Raubenheimer, D., and Simpson, S. J. (2003). Nutrient balancing in grasshoppers: Behavioural and physiological correlates of dietary breadth. The Journal of Experimental Biology 206, 1669-1681. doi:10.1242/jeb.00336 (Pubitemid 36599393)
131. Raubenheimer, D., and Simpson,S. J. (2006).The challenge of supplementary feeding: Can geometric analysis help save the kakapo? Notornis 53, 100-111.
132. Raubenheimer, D., and Simpson, S. J. (2009). Nutritional pharmecology: Doses, nutrients, toxins, and medicines. Integrative and Comparative Biology 49, 329-337. doi:10.1093/icb/icp050
133. Raubenheimer, D., and Tucker, D. (1997). Associative learning by locusts: Pairing of visual cues with consumption of protein and carbohydrate. Animal Behaviour 54, 1449-1459. doi:10.1006/anbe.1997.0542 (Pubitemid 28037938)
134. Raubenheimer, D., Lee, K. P., and Simpson, S. J. (2005). Does Bertrand's rule apply to macronutrients? Proceedings. Biological Sciences 272, 2429-2434. doi:10.1098/rspb.2005.3271 (Pubitemid 41579371)
135. Raubenheimer, D., Mayntz, D., Simpson, S. J., and Tøft, S. (2007). Nutrient specific compensation following overwintering diapause in a generalist predatory invertebrate: Implications for intraguild predations. Ecology 88, 2598-2608. doi:10.1890/07-0012.1 (Pubitemid 351345116)
136. Raubenheimer, D., Simpson, S. J., and Mayntz, D. (2009). Nutrition, ecology and nutritional ecology: Toward an integrated framework. Functional Ecology 23, 4-16. doi:10.1111/j.1365-2435.2009.01522.x
137. Ribeiro, C., and Dickson, B. J. (2010). Sex peptide receptor and neuronal TOR/S6K signaling modulate nutrient balancing in Drosophila. Current Biology 20, 1000-1005. doi:10.1016/j.cub.2010.03.061
138. Rodriguez, E., and Wrangham, R. (1993). Zoopharmacognosy: The use of medicinal plants by animals. In 'Recent Advances in Phytochemistry. Phytochemical Potential of Tropical Plants. Vol. 27'. (Eds K. R.Downum, J. T. Romeo, and H. A. Stafford.) pp. 89-105. (Plenum Press:NewYork.)
139. Romano, M. D., Piatt, J. F., and Roby, D. D. (2006). Testing the junk-food hypothesis on marine birds: Effects of prey type on growth and development. Waterbirds 29, 407-414. doi:10.1675/1524-4695(2006)29 [407:TTJHOM]2.0.CO;2 (Pubitemid 46344442)
140. Rosen, D. A. S., and Trites, A. W. (2000). Pollock and the decline of Steller sea lions: Testing the junk-food hypothesis. Canadian Journal of Zoology 78, 1243-1250. doi:10.1139/z00-060
141. Ross, M. H. (1961). Length of life and nutrition in the rat. The Journal of Nutrition 75, 197-210.
142. Rubio, V. C., Sánchez-Vázquez, F. J., and Madrid, J. A. (2003). Macronutrient selection through postingestive signals in sea bass fed on gelatine capsules. Physiology& Behavior 78, 795-803. doi:10.1016/S0031-9384 (03)00082-9
143. Sánchez-Vázquez, F. J., Yamamoto, T., Akiyama, T., Madrid, J. A., and Tabata, M. (1999). Macronutrient self-selection through demand-feeders in rainbow trout. Physiology & Behavior 66, 45-51. doi:10.1016/S0031-9384(98)00313-8 (Pubitemid 29155257)
144. Schoonhoven, L. M., van Loon, J. J. A., and Dicke, M. (2005). 'Insect-Plant Biology.' (Oxford University Press: Oxford.)
145. Schwartz, S. M., Kemnitz, J. W., and Howard, C. F. (1993). Obesity in freeranging rhesus macaques. International Journal of Obesity 17, 1-9.
146. Schwartz, M. W., Woods, S. C., Porte, D. Jr. Seeley, R. J., and Baskin, D. G. (2000). Central nervous control of food intake. Nature 404, 661-671. (Pubitemid 30205071)
147. Sclafani, A. (2000). Macronutrient-conditioned flavor preferences. In 'Neural and Metabolic Control of Macronutrient Intake'. (Eds H.-R. Berthoud and R. J. Seeley.) pp. 93-107. (CRC Press: Boca Raton, FL.)
148. Shuster, S. M., Lonsdorf, E. V., Wimp, G. M., Bailey, J. K., and Whitham, T. G. (2006). Community heritability measures the evolutionary consequences of indirect genetic effects on community structure. Evolution 60, 991-1003. (Pubitemid 44804498)
149. Silva, J. E. (2006). Thermogenic mechanisms and their hormonal regulation. Physiological Reviews 86, 435-464. doi:10.1152/physrev.00009.2005
150. Simpson, S. J., and Raubenheimer, D. (1993). A multi-level analysis of feeding behaviour: The geometry of nutritional decisions. Philosophical Transactions of the Royal Society B. Biological Sciences 342, 381-402. doi:10.1098/rstb.1993.0166 (Pubitemid 2029737)
151. Simpson, S. J., and Raubenheimer, D. (1995). The geometric analysis of feeding and nutrition: A user's guide. Journal of Insect Physiology 41, 545-553. doi:10.1016/0022-1910(95)00006- (Pubitemid 26451241)
152. Simpson, S. J., and Raubenheimer, D. (1997). The geometric analysis of feeding and nutrition in the rat. Appetite 28, 201-213. doi:10.1006/appe.1996. 0077 (Pubitemid 27308175)
153. Simpson, S. J., and Raubenheimer, D. (2000). The hungry locust. Advances in the Study of Behavior 29, 1-44. doi:10.1016/S0065-3454(08)60102-3
154. Simpson, S. J., and Raubenheimer, D. (2001). The geometric analysis of nutrient-allelochemical interactions: A case study using locusts. Ecology 82, 422-439. (Pubitemid 32152264)
155. Simpson, S. J., and Raubenheimer, D. (2005). Obesity: The protein leverage hypothesis. Obesity Reviews 6, 133-142. doi:10.1111/j.1467-789X.2005. 00178.x (Pubitemid 40604422)
156. Simpson, S. J., and Raubenheimer, D. (2007). Caloric restriction and aging revisited: The need for a geometric analysis of the nutritional bases of aging. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 62, 707-713. doi:10.1093/gerona/62.7.707 (Pubitemid 350143600)
157. Simpson, S. J., and Raubenheimer, D. (2009). Macronutrient balance and lifespan. Aging 1, 875-880.
158. Simpson, S. J., and Raubenheimer, D. (2012). 'The Nature of Nutrition: A Unifying Framework from Animal Adaptation to Human Obesity.' (Princeton University Press: Princeton, NJ.)
159. Simpson, S. J., and White, P. R. (1990). Associative learning and locust feeding: Evidence for a 'learned hunger' for protein. Animal Behaviour 40, 506-513. doi:10.1016/S0003-3472(05)80531-7
160. Simpson, S. J., Raubenheimer, D., Behmer, S. T., Whitworth, A., and Wright, G. A. (2002). A comparison of nutritional regulation in solitarious and gregarious phase nymphs of the desert locust, Schistocerca gregaria. The Journal of Experimental Biology 205, 121-129. (Pubitemid 34861265)
161. Simpson, S. J., Sibly, R. M., Lee, K. P., Behmer, S. T., and Raubenheimer, D. (2004). Optimal foraging when regulating intake of multiple nutrients. Animal Behaviour 68, 1299-1311. doi:10.1016/j.anbehav.2004.03.003 (Pubitemid 39588471)
162. Simpson, S. J., Sword, G. A., Lorch, P. D., and Couzin, I. D. (2006). Cannibal crickets on a forced march for protein and salt. Proceedings of the National Academy of Sciences of the United States of America 103, 4152-4156. doi:10.1073/pnas.0508915103
163. Simpson, S. J., Raubenheimer, D., Charleston, M.A., and Clissold, F. J.ARCNZ Vegetation Function Network Herbivory Working Group. (2010). Modelling nutritional interactions: From individuals to communities. Trends in Ecology & Evolution 25, 53-60. doi:10.1016/j.tree.2009. 06.012
164. Skorupa, D. A., Dervisefendic, A., Zwiener, J., and Pletcher, S. D. (2008). Dietary composition specifies consumption, obesity, and lifespan in Drosophila melanogaster. Aging Cell 7, 478-490. doi:10.1111/j.1474-9726.2008. 00400.x (Pubitemid 351998608)
165. Slansky, F. (1992). Allelochemical-nutrient interactions in herbivore nutritional ecology. In 'Herbivores: Their Interaction with Secondary Plant Metabolites'. (Eds G. A. Rosenthal and M. R. Berenbaum.) pp. 135-174. (Academic Press: New York.)
166. Smith, V. H., and Holt, R. D. (1996). Resource competition and within-host disease dynamics. Trends in Ecology & Evolution 11, 386-389. doi:10.1016/0169-5347(96)20067-9 (Pubitemid 126381533)
167. Sørensen, A., Mayntz, D., Simpson, S. J., and Raubenheimer, D. (2010). Dietary ratio of protein to carbohydrate induces plastic responses in the gastrointestinal tract of mice. Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology 180, 259-266. doi:10.1007/s00360-009-0402-0
168. Sotka, E. E., Forbey, J., Horn, M., Poore, A., Raubenheimer, D., and Whalen, K. (2009). The emerging role of pharmacology in understanding marine and freshwater consumer-prey interactions. Integrative and Comparative Biology 49, 291-313. doi:10.1093/icb/icp049
169. Sousa, T., Domingos, T., and Kooijman, S. A. L. M. (2008). From empirical patterns to theory: A formal metabolic theory of life. Philosophical Transactions of the Royal Society B. Biological Sciences 363, 2453-2464. doi:10.1098/rstb.2007.2230 (Pubitemid 351839871)
170. South, S. H., House, C. M., Moore, A. J., Simpson, S. J., and Hunt, J. (2011). Male cockroaches prefer a high carbohydrate diet that makes them more attractive to females: Implications for the study of condition-dependence. Evolution 65, 1594-1606. doi:10.1111/j.1558-5646.2011.01233.x
171. Stephens, D. W., and Krebs, J. R. (1986). 'Foraging Theory.' (Princeton University Press: Princeton, NJ.)
172. Stephens, D. W., Brown, J. S., and Ydenberg, R. C. (2007). 'Foraging: Behavior and Ecology.' (The University of Chicago Press: Chicago, IL.)
173. Sterner, R. W., and Elser, J. J. (2002). 'Ecological Stoichiometry: The Biology of Elements from Molecules to the Biosphere.' (Princeton University Press: Princeton, NJ.)
174. Sterner, R. W., Elser, J. J., Chrzanowski, T. H., Schampel, J. H., and George, N. B. (1996). Biogeochemistry and trophic ecology: A new food web diagram. In 'Food Webs: Integration of Patterns and Dynamics'. (Eds G. A. Polis and K. O. Winemiller.) pp. 72-80. (Chapman and Hall: New York.)
175. Stock, M. J. (1999). Gluttony and thermogenesis revisited. International Journal of Obesity 23, 1105-1117. doi:10.1038/sj.ijo.0801108
176. Sword, G. A., Lorch, P. D., and Gwynne, D. T. (2005). Migratory bands give crickets protection. Nature 433, 703. doi:10.1038/433703a (Pubitemid 40292970)
177. Tatar, M. (2007). Diet restriction in Drosophila melanogaster. In 'Mechanisms of Dietary Restriction in Aging and Disease'. (Eds C. V. Mobbs, K. Yen, and P. R. Hof.) pp. 115-136. (Karger: Basel.)
178. Tatar, M. (2011). The plate half-full: Status of research on the mechanisms of dietary restriction in Drosophila melanogaster. Experimental Gerontology 46, 363-368. doi:10.1016/j.exger.2010.12.002
179. Tilman, D. (1982). 'Resource Competition and Community Structure.' (Princeton University Press: Princeton, NJ.)
180. Tomé, D. (2004). Protein, amino acids and the control of food intake. The British Journal of Nutrition 92, S27-S30. doi:10.1079/BJN20041138 (Pubitemid 39214258)
181. Torregrossa, A.-M., and Dearing, D. (2009). Nutritional toxicology of mammals: Regulated intake of plant secondary compounds. Functional Ecology 23, 48-56. doi:10.1111/j.1365-2435.2008.01523.x
182. Touzani, K., and Sclafani, A. (2005). Critical role of amygdala in flavor but not taste preference learning in rats. The European Journal of Neuroscience 22, 1767-1774. doi:10.1111/j.1460-9568.2005.04360.x (Pubitemid 41482965)
183. Turnbaugh, P. J., Ridaura, V. K., Faith, J. J., Rey, F. E., Knight, R., and Gordon, G I (2009). The effect of diet on the human gut microbiome: A metagenomic analysis in humanized gnotobiotic mice. Science Translational Medicine 1, 6-14.
184. Vargas, M. A., Luo, N., Yamaguchi, A., and Kapahi, P. (2010). A role for S6 kinase and serotonin in postmating dietary switch and balance of nutrients in D. melanogaster. Current Biology 20, 1006-1011. doi:10.1016/j.cub.2010.04.009
185. Vigne, P., and Frelin, C. (2010). Hypoxia modifies the feeding preferences of Drosophila. Consequences for diet dependent hypoxic survival. BMC Physiology 10, 1-9. doi:10.1186/1472-6793-10-8
186. Villalba, J. J., and Provenza, F. D. (2007). Self-medication and homeostatic behaviour in herbivores: Learning about the benefits of nature's pharmacy. Animal 1, 1360-1370. doi:10.1017/S1751731107000134 (Pubitemid 47519274)
187. Warbrick-Smith, J., Behmer, S. T., Lee, K. P., Raubenheimer, D., and Simpson, S. J. (2006). Evolving resistance to obesity in an insect. Proceedings of the National Academy of Sciences of the United States of America 103, 14 045-14 049. doi:10.1073/pnas.0605225103 (Pubitemid 44452977)
188. Weindruch, R., and Walford, R. L. (1988). 'The Retardation of Aging and Disease by Dietary Restriction.' (Charles C. Thomas: Springfield, IL.)
189. White, T. C. R. (1983). 'The Inadequate Environment: Nitrogen and the Abundance of Animals.' (Springer: Berlin.)
190. Wilder, S. M., and Eubanks, M. D. (2010). Might nitrogen limitation promote omnivory among carnivorous arthropods? Ecology 91, 3114-3117. doi:10.1890/09-2080.1
191. Withers, P. C., and Cooper, C. E. (2010). Metabolic depression: A historical perspective. In 'Aestivation: Molecular and Physiological Aspects. Progress in Molecular and Subcellular Biology. Vol. 49'. (Eds C. A. Navas and J. E. Carvalho.) pp. 1-23. (Springer: Berlin.)
192. Yarmolinsky, D. A., Zuker, C. S., and Ryba, N. J. (2009). Common sense about taste: From mammals to insects. Cell 139, 234-244. doi:10.1016/j.cell. 2009.10.001
193. Zanotto, F. P., Simpson, S. J., and Raubenheimer, D. (1993). The regulation of growth by locusts through post-ingestive compensation for variation in the levels of dietary protein and carbohydrate. Physiological Entomology 18, 425-434. doi:10.1111/j.1365-3032.1993.tb00617.x (Pubitemid 2026926)
194. Zanotto, F. P., Gouveia, S. M., Simpson, S. J., Raubenheimer, D., and Calder, P. C. (1997). Nutritional homeostasis in locusts: Is there a mechanism for increased energy expenditure during carbohydrate overfeeding? The Journal of Experimental Biology 200, 2437-2448. (Pubitemid 27439755)
195. Zera, A. J., and Harshman, L. G. (2001). The physiology of life history tradeoffs in animals. Annual Review of Ecology and Systematics 32, 95-126. doi:10.1146/annurev.ecolsys.32.081501.114006 (Pubitemid 34043157)
196. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J. M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432. doi:10.1038/372425a0 (Pubitemid 24365442)
197. Zimmerman, J. A., Malloy, V., Krajcik, R., and Orentreich, N. (2003). Nutritional control of aging. Experimental Gerontology 38, 47-52. doi:10.1016/S0531-5565(02)00149-3 (Pubitemid 36113261)