Testing protein leverage in lean humans: A randomised controlled experimental study

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Gosby, Alison K ^a   Conigrave, Arthur D ^a   Lau, Namson S ^a   Iglesias, Miguel A ^a   Hall, Rosemary M ^b   Jebb, Susan A ^b   Brand Miller, Jennie ^a   Caterson, Ian D ^a   Raubenheimer, David ^c   Simpson, Stephen J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c MASSEY UNIVERSITY   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; FAT; PROTEIN; UREA; SODIUM CHLORIDE;

ADULT; ARTICLE; CALORIC INTAKE; CARBOHYDRATE INTAKE; CONTROLLED STUDY; DIETARY INTAKE; EXPERIMENTAL STUDY; FAT INTAKE; FEEDING BEHAVIOR; FEMALE; FOOD AVAILABILITY; FOOD COMPOSITION; FOOD QUALITY; HUMAN; HUMAN EXPERIMENT; HUNGER; HYPOTHESIS; LEAN BODY WEIGHT; MACRONUTRIENT; MALE; MEAL; NORMAL HUMAN; OBESITY; PALATABILITY; PROTEIN APPETITE; PROTEIN INTAKE; PROTEIN LEVERAGE HYPOTHESIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); WEIGHT GAIN; ADOLESCENT; BODY WEIGHT; CARBOHYDRATE DIET; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DIETARY FIBER; ENERGY METABOLISM; METABOLISM; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ADULT; DIETARY CARBOHYDRATES; DIETARY FIBER; DIETARY PROTEINS; ENERGY METABOLISM; FEMALE; HUMANS; HUNGER; MALE; MIDDLE AGED; SODIUM CHLORIDE; THINNESS; YOUNG ADULT;

EID: 80053994168     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025929     Document Type: Article

References (55)

1. Swinburn BA, Sacks G, Lo SK, Westerterp KR, Rush EC, et al. (2009) Estimating the changes in energy flux that characterize the rise in obesity prevalence. Am J Clin Nutr 89 (6): 1723-1728.
2. Simpson SJ, Raubenheimer D, (2005) Obesity: the protein leverage hypothesis. Obes Rev 6 (2): 133-142.
3. Simpson SJ, Batley R, Raubenheimer D, (2003) Geometric analysis of macronutrient intake in humans: the power of protein? Appetite 41 (2): 123-140.
4. Westerterp-Plantenga MS, (2004) Fat intake and energy-balance effects. Physiol Behav 83 (4): 579-585.
5. FAOSTAT database (2010) Food Balance Sheets [Online]. Available: http://faostat.fao.org/site/368/default.aspx#ancor. Accessed 2010 Sep 15.
6. Austin GL, Ogden LG, Hill JO, (2011) Trends in carbohydrate, fat and protein intakes and association with energy intake in normal-weight, overweight, and obese individuals: 1971-2006. Am J Clin Nutr 93 (4): 836-843.
7. Larsen TM, Dalskov SM, van Baak M, Jebb SA, Papadaki A, et al. (2010) Diets with high or low protein content and glycemic index for weight-loss maintenance. N Engl J Med 363 (22): 2102-2113.
8. Felton AM, Felton A, Lindenmayer DB, Foley WJ, (2009) Nutritional goals of wild primates. Functional Ecology 23 (1): 70-78.
9. Kyriazakis I, Emmans GC, Whittemore CT, (1991) The ability of pigs to control their protein intake when fed in three different ways. Physiol Behav 50 (6): 1197-1203.
10. Webster AJ, (1993) Energy partitioning, tissue growth and appetite control. Proc Nutr Soc 52 (1): 69-76.
11. Sørensen A, Mayntz D, Raubenheimer D, Simpson SJ, (2008) Protein-leverage in mice: the geometry of macronutrient balancing and consequences for fat deposition. Obesity 16 (3): 566-571.
12. Shariatmadari F, Forbes JM, (1993) Growth and food intake responses to diets of different protein contents and a choice between diets containing two concentrations of protein in broiler and layer strains of chicken. Br Poult Sci 34 (5): 959-970.
13. Raubenheimer D, Zemke-White WL, Phillips RJ, Clements KD, (2005) Algal macronutrients and food selection by the omnivorous marine fish Girella tricuspidata. Ecology 86 (10): 2601-2610.
14. Raubenheimer D, Simpson SJ, (1997) Integrative models of nutrient balancing: application to insects and vertebrates. Nutr Res Rev 10 (1): 151-179.
15. Brooks RC, Simpson SJ, Raubenheimer D, (2010) The price of protein: combining evolutionary and economic analysis to understand excessive energy consumption. Obes Rev 11 (12): 887-894.
16. Eaton SB, (2006) The ancestral human diet: what was it and should it be a paradigm for contemporary nutrition? Proc Nutr Soc 65 (1): 1-6.
17. Cordain L, Miller JB, Eaton SB, Mann N, Holt SH, et al. (2000) Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter-gatherer diets. Am J Clin Nutr 71 (3): 682-692.
18. Weigle DS, Breen PA, Matthys CC, Callahan HS, Meeuws KE, et al. (2005) A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations. Am J Clin Nutr 82 (1): 41-48.
19. Skov AR, Toubro S, Ronn B, Holm L, Astrup A, (1999) Randomized trial on protein vs carbohydrate in ad libitum fat reduced diet for the treatment of obesity. Int J Obes Relat Metab Disord 23 (5): 528-536.
20. Due A, Toubro S, Skov AR, Astrup A, (2004) Effect of normal-fat diets, either medium or high in protein, on body weight in overweight subjects: a randomised 1-year trial. Int J Obes Relat Metab Disord 28 (10): 1283-1290.
21. Due A, Toubro S, Stender S, Skov AR, Astrup A, (2005) The effect of diets high in protein or carbohydrate on inflammatory markers in overweight subjects. Diabetes Obes Metab 7 (3): 223-229.
22. Gosby AK, Soares-Wynter S, Campbell C, Badaloo A, Antonelli M, et al. (2010) Design and testing of foods differing in protein to energy ratios. Appetite 55 (2): 367-370.
23. Human energy requirements Scientific background papers from the Joint FAO/WHO/UNU Expert Consultation. October 17-24, 2001 (2005). Public Health Nutr 8 (7A): 929-1228.
24. Stock MJ, (1999) Gluttony and thermogenesis revisited. Int J Obes 23: 1105-1117.
25. Brown WJ, Williams L, Ford JH, Ball K, Dobson AJ, (2005) Identifying the energy gap: magnitude and determinants of 5-year weight gain in midage women. Obes Res 13 (8): 1431-1441.
26. Hall KD, Sacks G, Chandramohan D, Chow CC, Wang YC, et al. (2011) Quantification of the effect of energy balance on bodyweight. Lancet 378: 826-37.
27. Keast DR, Nicklas TA, O'Neil CE, (2010) Snacking is associated with reduced risk of overweight and reduced abdominal obesity in adolescents: National Health and Nutrition Examination Survey (NHANES) 1999-2004. Am J Clin Nutr 92 (2): 428-435.
28. Kerver JM, Yang EJ, Obayashi S, Bianchi L, Song WO, (2006) Meal and snack patterns are associated with dietary intake of energy and nutrients in US adults. J Am Diet Assoc 106 (1): 46-53.
29. Johnson L, Wilks DC, Lindroos AK, Jebb SA, (2009) Reflections from a systematic review of dietary energy density and weight gain: is the inclusion of drinks valid? Obes Rev 10 (6): 681-692.
30. Popkin BM, Duffey KJ, (2010) Does hunger and satiety drive eating anymore? Increasing eating occasions and decreasing time between eating occasions in the United States. Am J Clin Nutr 91 (5): 1342-1347.
31. Stubbs RJ, Johnstone AM, Mazlan N, Mbaiwa SE, Ferris S, (2001) Effect of altering the variety of sensorially distinct foods, of the same macronutrient content, on food intake and body weight in men. Eur J Clin Nutr 55 (1): 19-28.
32. Maillot M, Vieux F, Ferguson EF, Volatier JL, Amiot MJ, et al. (2009) To meet nutrient recommendations, most French adults need to expand their habitual food repertoire. J Nutr 139 (9): 1721-1727.
33. Brondel L, Romer M, Van Wymelbeke V, Pineau N, Jiang T, et al. (2009) Variety enhances food intake in humans: role of sensory-specific satiety. Physiol Behav 97 (1): 44-51.
34. Norton GN, Anderson AS, Hetherington MM, (2006) Volume and variety: relative effects on food intake. Physiol Behav 87 (4): 714-722.
35. Nolan LJ, Hetherington MM, (2009) The effects of sham feeding-induced sensory specific satiation and food variety on subsequent food intake in humans. Appetite 52 (3): 720-725.
36. Potier M, Fromentin G, Calvez J, Benamouzig R, Martin-Rouas C, et al. (2009) A high-protein, moderate-energy, regular cheesy snack is energetically compensated in human subjects. Br J Nutr 102 (4): 625-631.
37. Johnstone AM, Shannon E, Whybrow S, Reid CA, Stubbs RJ, (2000) Altering the temporal distribution of energy intake with isoenergetically dense foods given as snacks does not affect total daily energy intake in normal-weight men. Br J Nutr 83 (1): 7-14.
38. Marmonier C, Chapelot D, Louis-Sylvestre J, (2000) Effects of macronutrient content and energy density of snacks consumed in a satiety state on the onset of the next meal. Appetite 34 (2): 161-168.
39. Lejeune MPGM, Westerterp KR, Adam TCM, Luscombe-Marsh ND, Westerterp-Plantenga MS, (2006) Ghrelin and glucagon-like peptide 1 concentrations, 24-h satiety, and energy and substrate metabolism during a high-protein diet and measured in a respiration chamber. Am J Clin Nutr 83: 89-94.
40. Gietzen DW, Hao S, Anthony TG, (2007) Mechanisms of Food Intake Repression in Indispensable Amino Acid Deficiency. Annu Rev Nutr 27: 63-78.
41. Simpson SJ, Raubenheimer D, (2009) Macronutrient balance and lifespan. Aging 1 (10): 875-880.
42. Potier M, Darcel N, Tomé D, (2009) Protein, amino acids and the control of food intake. Curr Opin Clin Nutr Metab Care 12: 54-58.
43. Tannous dit El Khoury D, Obeid O, Azar ST, Hwalla N, (2006) Variations in postprandial ghrelin status following ingestion of high-carbohydrate, high-fat, and high-protein meals in males. Ann Nutr Metab 50 (3): 260-269.
44. Leidy HJ, Armstrong CL, Tang M, Mattes RD, Campbell WW, (2010) The Influence of Higher Protein Intake and Greater Eating Frequency on Appetite Control in Overweight and Obese Men. Obesity 18 (9): 1725-1732.
45. Cheng K, Simpson SJ, Raubenheimer D, (2008) A geometry of regulatory scaling. Am Nat 172 (5): 681-693.
46. Prentice A, Jebb S, (2004) Energy intake/physical activity interactions in the homestasis of body weight regulation. Nutr Rev 62 (7, Part2): S98-104.
47. Lee KP, Simpson SJ, Clissold FJ, Brooks R, Ballard JW, et al. (2008) Lifespan and reproduction in Drosophila: New insights from nutritional geometry. Proc Natl Acad Sci U S A 105 (7): 2498-2503.
48. Metges CC, Barth CA, (2000) Metabolic consequences of a high dietary-protein intake in adulthood: assessment of the available evidence. J Nutr 130 (4): 886-889.
49. Stubbs RJ, Harbron CG, Murgatroyd PR, Prentice AM, (1995) Covert manipulation of dietary fat and energy density: effect on substrate flux and food intake in men eating ad libitum. Am J Clin Nutr 62 (2): 316-329.
50. Long SJ, Jeffcoat AR, Millward DJ, (2000) Effect of habitual dietary-protein intake on appetite and satiety. Appetite 35 (1): 79-88.
51. Tomé D, Bos C, (2000) Dietary protein and nitrogen utilization. Journal of Nutrition 130 (7): 1868S-1873S.
52. Simpson SJ, Raubenheimer D, (1997) Geometric analysis of macronutrient selection in the rat. Appetite 28 (3): 201-213.
53. Flint A, Raben A, Blundell JE, Astrup A, (2000) Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord 24 (1): 38-48.
54. R Development Core Team (2010) R: a language and environment for statistical computing. Available: http://www.R-project.org. Accessed 2010 Sep 15.
55. Hothorn T, Bretz F, Westfall P, (2008) Simultaneous inference in general parametric models. Biom J 50 (3): 346-363.