Histopathological, enzymatic, and molecular alterations induced by cigarette smoke inhalation in the pulmonary tissue of mice and its amelioration by aqueous azadirachta indica leaf extract

Journal of Environmental Pathology, Toxicology and Oncology

Volumn 31, Issue 1, 2012, Pages 7-15

  Koul, Ashwani ^a   Kapoor, Neha ^a   Bharati, Sanjay ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Azadirachta indica; Chemoprevention; FT IR

Indexed keywords

AMIDE; AZADIRACHTA INDICA EXTRACT; CARCINOGEN; CIGARETTE SMOKE; CYTOCHROME P450; ETHYL 6 DEOXY 3,5 DI O METHYL 6 (3 METHYL 3 NITROSOUREIDO) ALPHA GLUCOFURANOSIDE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; LUNG ENZYME; MALONALDEHYDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; AZADIRACHTA INDICA; CANCER PREVENTION; CANCER RISK; CIGARETTE SMOKING; CONTROLLED STUDY; DETOXIFICATION; HISTOPATHOLOGY; INFRARED SPECTROSCOPY; LIPID PEROXIDATION; LUNG CANCER; LUNG INFILTRATE; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; OXYGEN TENSION; PLANT LEAF; PNEUMONIA; PRIORITY JOURNAL; XENOBIOTIC METABOLISM;

ANIMALIA; AZADIRACHTA INDICA; MUS;

EID: 84861907731     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: 10.1615/JEnvironPatholToxicolOncol.v31.i1.20     Document Type: Article

References (34)

1. Edwards TM, Myers JP. Environmental exposures and gene regulation in disease etiology. Environ Health Perspect. 2007:115(9):1264-1270.
2. Malcolm RL, Hackshaw AK. Environmental tobacco smoke. Br Med Bull. 1996:52(1):22-34.
3. Bruin JE, Gerstein SC, Holloway AC. Longterm consequences of fetal and neonatal nicotine exposure: a critical review. Toxicol Sci. 2010:116(2):364-374.
4. Bernert JT, Pirkle JL, Xia Y, Jain RB, Ashley DL, Sampson EJ. Urine concentrations of a tobaccospecific nitrosamine carcinogen in the U.S. population from secondhand smoke exposure. CancerEpidemiol Biomarkers Prev. 2010:19:2969-2977.
5. Hecht SS, Kassie F, Hatsukami DK. Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers. Nat Rev Cancer. 2009:9:476-488.
6. Puliyappadamba VT, Cheriyan VT, Thulasidasan AK, Bava SV, Vinod BS, Prabhu PR, Varghese R, Bevin A, Venugopal S, Anto RJ. Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010:9:220.
7. Arora N, Koul A, Bansal MP. Chemopreventive activity of Azadirachta indica on two-stage skin carcinogenesis in murine model. Phytother Res. 2011:25(3):408-416.
8. Manikandan P, Letchoumy PV, Gopalakrishnan M, Nagini M. Evaluation of Azadirachta indica leaf fractions for in vitro antioxidant potential and in vivo modulation of biomarkers of chemoprevention in the hamster buccal pouch carcinogenesis model. Food Chem Toxicol. 2008:46(7):2332-2343.
9. Chaube SK, Prasad PV, Khillare B, Shrivastav TG. Extract of Azadirachta indica (neem) leaf induces apoptosis in rat oocytes cultured in vitro. Fertil Steril. 2006:85(Suppl 1):1223-1231.
10. Koul A, Arora N. Celecoxib mitigates cigarette smoke induced oxidative stress in mice. Indian J Biochem Biophys. 2010:47(5):285-291.
11. Gangar SC, Sandhir R, Rai DV, Koul A. Preventive effects of Azadirachta indica on benzo(a)pyrene- DNA adduct formation in murine forestomach and hepatic tissues. Phytother Res. 2006:20(10):889-895.
12. Guidolin LBM, Murakami LS, Nomizo A, Bachmann L. Fourier transform infrared spectroscopy of skin cancer cells and tissues. Appl Spectrosc. 2009:44:438-455.
13. Omura J, Sato R. The carbon-monoxide binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J Biol Chem. 1964:239:2370-2378.
14. Habig WH, Pabst MJ, Jakoby WB. Glutathione Stransferases: the first enzymatic step in mercapturic acid formation. J Biol Chem. 1974:249:7130-7139.
15. Moron MS, Depierre JW, Mannervik B. Levels of glutathione, glutathione reductase and glutathione- S-transferase activities in rat lung and liver. Biochim Biophys Acta. 1979:582:67-78.
16. Trush MA, Mimnaugh EG, Ginsburg E, Gram TE. In vitro stimulation by paraquat of reactive oxygenmediated lipid peroxidation in rat lung microsomes. Toxicol Appl Pharmacol. 1981:60:279-286.
17. Petibois C, Deleris G. Chemical mapping of tumor progression by FT-IR imaging: towards molecular histopathology. Trends Biotechnol. 2006:24(10):455-462.
18. Song DJ. Environmental tobacco smoke and childhood asthma. Korean J Pediatr. 2010:53(2):121-128.
19. Smith John A. Neutrophils, host defense, and inflammation: a double-edged sword. J Leukoc Biol. 1994:56:672-686.
20. Petibios C, Deleris G. Oxidative stress effects on erythrocytes determined by FT-IR spectroscopy. Analyst. 2004:129:912-916.
21. Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med.1991:11:81-128.
22. Negre-Salvayre A, Coatrieux, C, Ingueneau C, Salvayre R. Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors. Br J Pharmacol. 2008:153:6-20.
23. Ding YS, Ashley DL, Watson CH. Determination of 10 carcinogenic polycyclic aromatic hydrocarbons in mainstream cigarette smoke. J Agric Food Chem. 2007:55(15):5966-5973.
24. Poirier MC, Beland FA. DNA adduct measurement and tumor incidence during chronic carcinogen exposure in animal models: implications for DNA adduct-based human cancer risk assessment. Chem Res Toxicol. 1992:5:749-755.
25. Gelhaus SL, Harvey RG, Penning TM, Blair IA. Regulation of benzo[a]pyrene-mediated DNA- and glutathione-adduct formation by 2,3,7,8-tetrachlorodibenzo- p-dioxin in human lung cells. Chem Res Toxicol. 2011:24(1):89-98.
26. Sundberg K, Dreij K, Seidel A, Jernström B. Glutathione conjugation and DNA adduct formation of dibenzo[a,l]pyrene and benzo[a]pyrene diol epoxides in V79 cells stably expressing different human glutathione transferases. Chem Res Toxicol. 2002:15(2):170-179.
27. Benedetti E, Teodori L, Trinca ML, Vergamini P, Salvati F, Mauro F, Spremolla G. A New approach to the study of human solid tumor cells by means of FT-IR microspectroscopy. Appl Spectrosc.1990:44(8):1276-1280.
28. Tarlo SM. Workplace irritant exposures: do they produce true occupational asthma? Ann Allergy Asthma Immunol. 2003:90(suppl 2):19-23.
29. Muñoz J, Bolufer P, Rodriguez A, Antonio P, Vazquez C. DNA/protein ratio as an index of oestrogen receptor content in human breast cancer. Eur J Cancer Clin Oncol. 1983:19(9):1207-1212.
30. Trombino A, Cesario S, Margaritora P, Granone G, Motta C, Falugi P, Russo. Alpha7-nicotinic acetylcholine receptors affect growth regulation of human mesothelioma cells: role of mitogenactivated protein kinase pathway. Cancer Res. 2004:64(1):135-145.
31. Trombino S, Bisio A, Catassi A, Cesario A, Falugi C, Russo P. Role of the non-neuronal human cholinergic system in lung cancer and mesothelioma: possibility of new therapeutic strategies. Curr Med Chem Anticancer Agents. 2004:4(6):535-542.
32. Schuller HM, Plummer HK 3rd, Jull BA. Receptor- mediated effects of nicotine and its nitrosated derivative NNK on pulmonary neuroendocrine cells. Anat Rec A Discov Mol Cell Evol Biol. 2003:270(1):51-58.
33. Wong HP, Yu L, Lam EK, Tai EK, Wu WK, Cho CH. Nicotine promotes colon tumor growth and angiogenesis through beta-adrenergic activation. Toxicol Sci. 2007:97(2):279-287.
34. Laag E, Majidi M, Cekanova M, Masi T, Takahashi T, Schuller HM. NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells. Int J Cancer. 2006:119(7):1547-1552.