Urine concentrations of a tobacco-specific nitrosamine carcinogen in the U.S. population from secondhand smoke exposure

Cancer Epidemiology Biomarkers and Prevention

Volumn 19, Issue 11, 2010, Pages 2969-2977

  Bernert, John T ^a   Pirkle, James L ^a   Xia, Yang ^a   Jain, Ram B ^a   Ashley, David L ^a   Sampson, Eric J ^a  

^a NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANOL; CIGARETTE SMOKE; COTININE;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD LEVEL; CHILD; CIGARETTE SMOKING; CONTROLLED STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; POPULATION EXPOSURE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; TANDEM MASS SPECTROMETRY; URINE LEVEL;

ADOLESCENT; ADULT; AGE DISTRIBUTION; BIOLOGICAL MARKERS; CARCINOGENS; CHILD; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HUMANS; MALE; MASS SPECTROMETRY; NITROSAMINES; NUTRITION SURVEYS; PYRIDINES; SMOKING; TOBACCO SMOKE POLLUTION; UNITED STATES; YOUNG ADULT;

EID: 78549278152     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-10-0711     Document Type: Article

References (26)

1. CDC (Centers for Disease Control and Prevention). Annual smoking-attributable mortality, years of potential life lost, and productivity losses - United States, 1997-2001. 2002, Available: http://www.cdc.gov/mmwr/ preview/mmwrhtml/mm5114a2.htm.[cited 2006 Dec 5].
2. CDC (Centers for Disease Control and Prevention). CDC. Hyattsville (MD): National Center for Health Statistics; 2009, (http://www.cdc.gov/nchs/nhanes. htm; accessed on January 30, 2010.
3. HHS (U.S. Department of Health and Human Services). The health consequences of smoking: a report of the surgeon general. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2004.
4. Vineis P, Alavanja M, Buffler P, et al. Tobacco and cancer: recent epidemiological evidence. J Natl Cancer Inst 2004;96:99-106.
5. Secretan B, Straif K, Baan R, et al. A review of human carcinogens - Part E: tobacco, areca nut, alcohol, coal smoke, and salted fish. Lancet Oncol 2009;10:1033-4.
6. HHS (U.S. Department of Health and Human Services). The health consequences of involuntary exposure to tobacco smoke: a report of the surgeon general. U.S. HHS Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2006.
7. IOM (Institute of Medicine). Clearing the smoke. Assessing the science base for tobacco harm reduction. Washington (DC): National Academy Press; 2001. p. 636.
8. Hoffman D, Hoffman I, El-Bayoumy K. The less harmful cigarette: a controversial issue. A tribute to Ernst L. Wynder. Chem Res Toxicol 2001;14:767-90.
9. Hecht SS. Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer. Carcinogenesis 2002;23:907-22.
10. National Research Council. Environmental tobacco smoke: measuring exposures and assessing health effects. Committee on Passive Smoking, Board on Environmental Studies and Toxicology. Washington (DC): National Academy Press; 1986.
11. Akoyan G, Bonavida B. Understanding tobacco smoke carcinogen NNK and lung turorigenesis. Int J Oncol 2006;29:745-52.
12. Hecht SS. Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nat Rev Cancer 2003;3:733-44.
13. Hecht SS. Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. Chem Res Toxicol 1998;11:559-603.
14. Hecht SS, Ye M, Carmella S, et al. Metabolites of a tobacco-specific lung carcinogen in the urine of elementary school-aged children. Cancer Epidemiol Biomarkers Prev 2001;10:1109-16.
15. Benowitz N. Cotinine as a biomarker of environmental tobacco smoke exposure. Environ Rev 1996;18:188-204.
16. SRNT Subcommittee on Biochemical Verification. Biochemical verification of tobacco use and cessation. Nicotine Tob Res 2002;4:149-59.
17. Xia Y, McGuffey JE, Bhattacharyya S, et al. Analysis of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in urine by extraction on a molecularly imprinted polymer column and liquid chromatography/atmospheric-pressure ionization tandem mass spectrometry. Anal Chem 2005;77:7639-45.
18. Xia Y, Bernert JT. Stability of the tobacco-specific nitrosamine 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanol)NNAL) in urine samples stored at various temperatures. J Anal Toxicol. In press 2010.
19. Caudill SP, Schleicher RL, Pirkle JL. Multi-rule quality control for the age-related eye disease study. Stat Med 2008;10:4094-106.
20. Pirkle JL, Flegal KM, Bernert JT, Brody DJ, Etzel RA, Maurer KR. Exposure of the U.S. population to environmental tobacco smoke: the Third National Health and Nutrition Examination Survey, 1988-1991. JAMA 1996;275:1233-40.
21. Benowitz NL, Bernert JT, Caraballo RS, Holiday DB, Wang J. Optimal serum cotinine levels for distinguishing cigarette smokers and nonsmokers within different racial/ethnic groups in the United States between 1999 and 2004. Am J Epidemiol 2009;169:236-48.
22. HHS (U.S. Department of Health and Human Services). Healthy people 2010: understanding and improving health. 2nd ed. Washington (DC): 2000.
23. Lackmann GM, Saltzberger U, Tooler U, Chen M, Carmella SG, Hecht SS. Metabolites of a tobacco-specific carcinogen in urine from newborns. J Natl Cancer Inst 1999;91:459-65.
24. Hecht SS, Carmella SG, Le KA, et al. 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanol and its glucuronides in the urine of infants exposed to environmental tobacco smoke. Cancer Epidemiol Biomarkers Prev 2006;15:988-92.
25. Stepanov I, Hecht SS, Duca G, Mardari I. Uptake of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by Moldavan children. Cancer Epidemiol Biomarkers Prev 2006;15:7-11.
26. Tulunay OE, Hecht SS, Carmella SG, et al. Urinary metabolites of a tobacco-specific lung carcinogen in nonsmoking hospitality workers. Cancer Epidemiol Biomarkers Prev 2005;14:1283-86.