An osteoclastic protein-tyrosine phosphatase regulates the β3-integrin, syk, and shp1 signaling through respective src-dependent phosphorylation in osteoclasts

American Journal of Physiology - Cell Physiology

Volumn 302, Issue 11, 2012, Pages 1676-1686

  William Lau, K H ^a,b   Stiffel, Virginia ^a   Amoui, Mehran ^a  

^a Jerry L Pettis Memorial VA Medical Center   (United States)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Rac; Resorption; siRNA; Trapping mutant pull down; Vav

Indexed keywords

BETA3 INTEGRIN; GLUTATHIONE TRANSFERASE; PROTEIN KINASE SYK; PROTEIN SRC; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; RAC1 PROTEIN; SMALL INTERFERING RNA; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL ASSAY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; GLUTATHIONE TRANSFERASE PULL DOWN ASSAY; INTRACELLULAR SIGNALING; MALE; MOUSE; NONHUMAN; OSTEOCLAST; PRIORITY JOURNAL; WESTERN BLOTTING;

ANIMALS; BONE RESORPTION; CELL LINE; INTEGRIN BETA3; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NEUROPEPTIDES; OSTEOCLASTS; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; PROTEIN TYROSINE PHOSPHATASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-VAV; RAC GTP-BINDING PROTEINS; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 84861856401     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00042.2012     Document Type: Article

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