Tracking a complete voltage-sensor cycle with metal-ion bridges

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 22, 2012, Pages 8552-8557

  Henrion, Ulrike ^a   Renhorn, Jakob ^a   Börjesson, Sara I ^a   Nelson, Erin M ^a   Schwaiger, Christine S ^b   Bjelkmar, Pär ^b,c   Wallner, Björn ^a   Lindahl, Erik ^b,c   Elinder, Fredrik ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^c STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Conformational transition; Electrophysiology; Inactivation; Voltage clamp; Xenopus oocytes

Indexed keywords

METAL ION; POTASSIUM CHANNEL; POTASSIUM CHANNEL KV1.2; POTASSIUM CHANNEL KV2.1; SHAKER POTASSIUM CHANNEL; UNCLASSIFIED DRUG; VOLTAGE GATED CHANNEL FORMING PROTEIN; VOLTAGE SENSOR DOMAIN;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; CRYSTAL STRUCTURE; ELECTRIC POTENTIAL; MEMBRANE POTENTIAL; MOLECULAR DYNAMICS; MOLECULAR SENSOR; NONHUMAN; OOCYTE; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIMULATION; X RAY CRYSTALLOGRAPHY; XENOPUS;

ANIMALS; BINDING SITES; CADMIUM; CHELATING AGENTS; COMPUTER SIMULATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EGTAZIC ACID; FEMALE; ION CHANNEL GATING; KINETICS; MEMBRANE POTENTIALS; METALS; MODELS, MOLECULAR; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; XENOPUS LAEVIS;

EID: 84861838905     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1116938109     Document Type: Article

References (50)

1. Borjesson SI, Elinder F (2008) Structure, function, and modification of the voltage sensor in voltage-gated ion channels. Cell Biochem Biophys 52:149-74.
2. Schoppa NE, et al. (1992) The size of gating charge in wild-type and mutant Shaker potassium channels. Science 255:1712-1715.
3. Zagotta WN, Hoshi T, Aldrich RW (1994) Shaker potassium channel gating III: Evaluation of kinetic models for activation. J Gen Physiol 103:321-62. (Pubitemid 24068562)
4. Keynes RD, Elinder F (1998) Modelling the activation, opening, inactivation and reopening of the voltage-gated sodium channel. Proc Biol Sci 265:263-70. (Pubitemid 28077517)
5. + channel in a lipid membrane-like environment. Nature 450:376-382.
6. + channel. Neuron 14:1293-301.
7. DeCaen PG, et al. (2008) Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation. Proc Natl Acad Sci USA 105:15142-15147.
8. DeCaen PG, et al. (2009) Sequential formation of ion pairs during activation of a sodium channel voltage sensor. Proc Natl Acad Sci USA 106:22498-22503.
9. Villalba-Galea CA, et al. (2008) S4-based voltage sensors have three major conformations. Proc Natl Acad Sci USA 105:17600-17607.
10. Murata Y, et al. (2005) Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. Nature 435:1239-1243. (Pubitemid 40943089)
11. Sasaki M, Takagi M, Okamura Y (2006) A voltage sensor-domain protein is a voltage-gated proton channel. Science 312:589-592.
12. Ramsey IS, et al. (2006) A voltage-gated proton-selective channel lacking the pore domain. Nature 440:1213-1216.
13. Ashcroft FM (1999) Ion Channels and Disease (Academic, San Diego), 1st Ed.
14. Sokolov S, Scheuer T, Catterall WA (2007) Gating pore current in an inherited ion channelopathy. Nature 446:76-78. (Pubitemid 46348048)
15. Borjesson SI, et al. (2010) Electrostatic tuning of cellular excitability. Biophys J 98:396-403.
16. Catterall WA, et al. (2007) Voltage-gated ion channels and gating modifier toxins. Toxicon 49:124-141. (Pubitemid 46151715)
17. Catterall WA (2010) Ion channel voltage sensors:structure, function, and pathophysiology. Neuron 67:915-928.
18. Borjesson SI, Elinder F (2011) An electrostatic potassium channel opener targeting the final voltage sensor transition. J Gen Physiol 137:563-577.
19. Hessa T, White SH, von Heijne G (2005) Membrane insertion of a potassium-channel voltage sensor. Science 307:1427. (Pubitemid 40321932)
20. Payandeh J, et al. (2011) The crystal structure of a voltage-gated sodium channel. Nature 475:353-358.
21. Schoppa NE, Sigworth FJ (1998) Activation of Shaker potassium channels. III. An activation gating model forwild-type and V2 mutant channels. J Gen Physiol 111:313-342. (Pubitemid 28113080)
22. + channels. Neuron 27:573-583.
23. Broomand A, Elinder F (2008) Large-scale movement within the voltage-sensor paddle of a potassium channel-support for a helical-screw motion. Neuron 59:770-777.
24. Careaga CL, Falke JJ (1992) Thermal motions of surface alpha-helices in the D-galactose chemosensory receptor Detection by disulfide trapping. J Mol Biol 226:1219-1235.
25. + channels defined by high-affinity metal bridges. Nature 428:864-868.
26. Campos FV, et al. (2007) Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed stateof Shaker K channel. Proc Natl Acad Sci USA 104:7904-7909. (Pubitemid 47185849)
27. Li M, et al. (2011) Gating the pore of P2X receptor channels. Nat Neurosci 11:883-887.
28. Lin MC, et al. (2011) R1 in the Shaker S4 occupies the gating charge transfer center in the resting state. J Gen Physiol 138:155-163.
29. 2+) in metalloproteins. J Inorg Biochem 71:115-127.
30. Vargas E, Bezanilla F, Roux B (2011) In search of a consensus model of the resting state of a voltage-sensing domain. Neuron 72:713-720.
31. Lehmann C, Heldstab H, Greeff NG (2012) Positioning and Guidance of the Voltage Sensor S4 Within the Omega/Gating-Pore in the Shaker K-Channel. Biophys J 102:532a.
32. Pless SA, et al. (2011) Contributions of counter-charge in a potassium channel voltage-sensor domain. Nat Chem Biol 7:617-623.
33. Schwaiger CS, et al. (2011) 3-helix conformation facilitates the transition of a voltage sensor S4 segment toward the down state. Biophys J 100:1446-1454.
34. Khalili-Araghi F, et al. (2010) Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel. Biophys J 98:2189-2198.
35. Schow EV, et al. (2010) Down-state model of the voltage-sensing domain of a potassium channel. Biophys J 98:2857-2866.
36. Pathak MM, et al. (2007) Closing in on the resting state of the Shaker K(+) channel. Neuron 56:124-140. (Pubitemid 47484186)
37. Tao X, et al. (2010) A gating charge transfer center in voltage sensors. Science 328:67-73.
38. Delemotte L, et al. (2011) Intermediate states of the Kv1.2 voltage sensor from atomistic molecular dynamics simulations. Proc Natl Acad Sci USA 108:6109-6114.
39. Cole KS, Moore JW (1960) Potassium ion current in the squid giant axon:dynamic characteristic. Biophys J 1:1-14.
40. Khalili-Araghi F, et al. (2012) Molecular Dynamics Investigation of the omega-Current in the Kv1.2 Voltage Sensor Domains. Biophys J 102:258-267.
41. Kamb A, Tseng-Crank J, Tanouye MA (1988) Multiple products of the Drosophila Shaker gene may contribute to potassium channel diversity. Neuron 1:421-430.
42. Hoshi T, Zagotta WN, Aldrich RW (1990) Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 250:533-538. (Pubitemid 120031778)
43. Soding J (2005) Protein homology detection by HMM-HMM comparison. Bioinformatics 21:951-960.
44. Sali A, Blundell TL (1993) Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 234:779-815. (Pubitemid 24007801)
45. Lindorff-Larsen K, et al. (2010) Improved side-chain torsion potentials for the Amber ff99SB protein force field. Proteins 78:1950-1958.
46. Berger O, Edholm O, Jahnig F (1997) Molecular dynamics simulations of a fluid bilayer of dipalmitoylphosphatidylcholine at full hydration, constant pressure, and constant temperature. Biophys J 72:2002-2013. (Pubitemid 27184429)
47. Jorgensen WL, et al. (1983) Comparison of simple potential functions for simulating liquid water. J Chem Phys 79:926-935.
48. Hess B, et al. (2008) GROMACS 4.0:Algorithms for highly efficient, load balanced, and scalable molecular simulation. J Chem Theory Comput 4:435-447.
49. Bussi G, Donadio D, Parrinello M (2007) Canonical sampling through velocity rescaling. J Chem Phys 126:014101-014107.
50. Parrinello M, Rahman A (1981) Polymorphic transitions in single crystals:A new molecular dynamics method. J Appl Phys 52:7182-7190. (Pubitemid 12456820)