Membrane insertion of a potassium-channel voltage sensor

Science

Volumn 307, Issue 5714, 2005, Pages 1427-

  Hessa, Tara ^a   White, Stephen H ^b   Von Heijne, Gunnar ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; BACTERIAL PROTEIN; GLYCINE; PROTEIN LEP; TRANSLOCON; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

MEMBRANE; SENSOR;

ACCURACY; AMINO ACID SEQUENCE; ARTICLE; CALCULATION; ELECTRIC POTENTIAL; ENDOPLASMIC RETICULUM; ENERGY; GLYCOSYLATION; HYDROPHOBICITY; LIPID BILAYER; MEASUREMENT; MEMBRANE DEPOLARIZATION; MODEL; NONHUMAN; PRIORITY JOURNAL; SENSOR;

ARGININE; CELL MEMBRANE; ENDOPLASMIC RETICULUM; ESCHERICHIA COLI PROTEINS; GLYCOSYLATION; HYDROPHOBICITY; INTRACELLULAR MEMBRANES; LIPID BILAYERS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; PLASMIDS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN STRUCTURE, SECONDARY; THERMODYNAMICS;

EID: 20044389842     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1109176     Document Type: Article

References (9)

1. Y. Jiang et al., Nature 423, 33 (2003).
2. Y. Jiang, V. Ruta, J. Chen, A. Lee, R. MacKinnon, Nature 423, 42 (2003).
3. M. Grabe, H. Lecar, Y. N. Jan, L. Y. Jan, Proc. Natl. Acad. Sci. U.S.A. 101, 17640 (2004).
4. T. Hessa et al., Nature 433, 377 (2005).
5. Materials and methods are available as supporting material on Science Online.
6. L. Tu, J. Wang, A. Helm, W. R. Skach, C. Deutsch, Biochemistry 39, 824 (2000).
7. R. MacKinnon, Science 306, 1304 (2004).
8. J. A. Freites, S. H. White, unpublished data.
9. We thank E. Missioux. Supported by the Swedish Cancer Foundation, the Marianne and Marcus Wallenberg Foundation, the Swedish Research Council (G.v.H.), and the National Institute of General Medical Sciences (grant nos. GM46823 and GM68002, S.H.W.).