Gene-sodium interaction and blood pressure: Findings from genomics research of blood pressure salt sensitivity

Progress in Molecular Biology and Translational Science

Volumn 108, Issue , 2012, Pages 237-260

  Kelly, Tanika N ^a   He, Jiang ^a,b  

^a TULANE UNIVERSITY   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Blood pressure; Dietary sodium; Genetics; Polymorphism; Salt sensitivity

Indexed keywords

EID: 84861836243     PISSN: 18771173     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-398397-8.00010-1     Document Type: Chapter

References (140)

1. P.M. Kearney, M. Whelton, K. Reynolds, P. Muntner, P.K. Whelton, and J. He Global burden of hypertension: analysis of worldwide data Lancet 365 2005 217 223
2. A.D. Lopez, C.D. Mathers, M. Ezzati, D.T. Jamison, and C.J.L. Murray Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data Lancet 367 2006 1747 1757
3. G. Danaei, M.M. Finucane, J.K. Lin, G.M. Singh, C.J. Paciorek, and M.J. Cowan National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5.4 million participants Lancet 377 2011 568 577
4. N. Kato, F. Takeuchi, Y. Tabara, T.N. Kelly, M.J. Go, and X. Sim Meta-analysis identifies five novel loci associated with blood pressure in East Asians Nat Genet 43 2011 531 538
5. D. Levy, G.B. Ehret, K. Rice, G.C. Verwoert, L.J. Launer, and A. Dehghan Genome-wide association study of blood pressure and hypertension Nat Genet 41 2009 677 687
6. C. Newton-Cheh, T. Johnson, V. Gateva, M.D. Tobin, M. Bochud, and L. Coin Genome-wide association study identifies eight loci associated with blood pressure Nat Genet 41 2009 666 676
7. J. He, and P.K. Whelton Salt intake, hypertension and risk of cardiovascular disease: an important public health challenge Int J Epidemiol 31 2002 327 331 discussion 331-332
8. A.V. Chobanian, and M. Hill National Heart, Lung, and Blood Institute Workshop on Sodium and Blood Pressure: a critical review of current scientific evidence Hypertension 35 2000 858 863
9. L. Tobian Salt and hypertension. Lessons from animal models that relate to human hypertension Hypertension 17 1991 I52 I58
10. D. Denton, R. Weisinger, N.I. Mundy, E.J. Wickings, A. Dixson, and P. Moisson The effect of increased salt intake on blood pressure of chimpanzees Nat Med 1 1995 1009 1016
11. P. Elliott, J. Stamler, R. Nichols, A.R. Dyer, R. Stamler, and H. Kesteloot Intersalt revisited: further analyses of 24 hour sodium excretion and blood pressure within and across populations. Intersalt Cooperative Research Group BMJ 312 1996 1249 1253 [Erratum appears in BMJ 1997 Aug 23;315(7106):458]
12. J. He, G.S. Tell, Y.C. Tang, P.S. Mo, and G.Q. He Relation of electrolytes to blood pressure in men. The Yi people study Hypertension 17 1991 378 385
13. J.A. Cutler, D. Follmann, and P.S. Allender Randomized trials of sodium reduction: an overview Am J Clin Nutr 65 1997 643S 651S
14. F.M. Sacks, L.P. Svetkey, W.M. Vollmer, L.J. Appel, G.A. Bray, and D. Harsha Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group N Engl J Med 344 2001 3 10
15. J. He, L.G. Ogden, S. Vupputuri, L.A. Bazzano, C. Loria, and P.K. Whelton Dietary sodium intake and subsequent risk of cardiovascular disease in overweight adults JAMA 282 1999 2027 2034
16. J. Tuomilehto, P. Jousilahti, D. Rastenyte, V. Moltchanov, A. Tanskanen, and P. Pietinen Urinary sodium excretion and cardiovascular mortality in Finland: a prospective study Lancet 357 2001 848 851
17. N.R. Cook, J.A. Cutler, E. Obarzanek, J.E. Buring, K.M. Rexrode, and S.K. Kumanyika Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP) BMJ 334 2007 885 888
18. P. Strazzullo, L. D'Elia, N.-B. Kandala, and F.P. Cappuccio Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies BMJ 339 2009 b4567
19. T. Kawasaki, C.S. Delea, F.C. Bartter, and H. Smith The effect of high-sodium and low-sodium intakes on blood pressure and other related variables in human subjects with idiopathic hypertension Am J Med 64 1978 193 198
20. M.H. Weinberger Salt sensitivity of blood pressure in humans Hypertension 27 1996 481 490
21. F.C. Luft, and M.H. Weinberger Heterogeneous responses to changes in dietary salt intake: the salt-sensitivity paradigm Am J Clin Nutr 65 1997 612S 617S
22. G. GenSalt Collaborative Research GenSalt: rationale, design, methods and baseline characteristics of study participants J Hum Hypertens 21 2007 639 646
23. J.-B. Marteau, M. Zaiou, G. Siest, and S. Visvikis-Siest Genetic determinants of blood pressure regulation J Hypertens 23 2005 2127 2143
24. R.P. Lifton, A.G. Gharavi, and D.S. Geller Molecular mechanisms of human hypertension Cell 104 2001 545 556
25. P.C. White Disorders of aldosterone biosynthesis and action N Engl J Med 331 1994 250 258
26. J.M. Connell, S.M. MacKenzie, E.M. Freel, R. Fraser, and E. Davies A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function Endocr Rev 29 2008 133 154
27. R.P. Lifton Molecular genetics of human blood pressure variation Science 272 1996 676 680
28. P. Ferrari, E. Lovati, and F.J. Frey The role of the 11beta- hydroxysteroid dehydrogenase type 2 in human hypertension J Hypertens 18 2000 241 248
29. J.W. Funder, P.T. Pearce, R. Smith, and A.I. Smith Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated Science 242 1988 583 585
30. J.W. Funder Mineralocorticoids, glucocorticoids, receptors and response elements Science 259 1993 1132 1133
31. P.M. Stewart, A.M. Wallace, R. Valentino, D. Burt, C.H. Shackleton, and C.R. Edwards Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age Lancet 2 1987 821 824
32. R.P. Lifton, R.G. Dluhy, M. Powers, G.M. Rich, S. Cook, and S. Ulick A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension Nature 355 1992 262 265
33. F.C. Luft Mendelian forms of human hypertension and mechanisms of disease Clin Med Res 1 2003 291 300
34. A.R. Lafferty, D.J. Torpy, M. Stowasser, S.E. Taymans, J.P. Lin, and P. Huggard A novel genetic locus for low renin hypertension: familial hyperaldosteronism type II maps to chromosome 7 (7p22) J Med Genet 37 2000 831 835
35. A. So, D.L. Duffy, R.D. Gordon, Y.W.A. Jeske, K. Lin-Su, and M.I. New Familial hyperaldosteronism type II is linked to the chromosome 7p22 region but also shows predicted heterogeneity J Hypertens 23 2005 1477 1484
36. M. Stowasser, R.D. Gordon, T.J. Tunny, S.A. Klemm, W.L. Finn, and A.L. Krek Familial hyperaldosteronism type II: five families with a new variety of primary aldosteronism Clin Exp Pharmacol Physiol 19 1992 319 322
37. D.S. Geller, J. Zhang, M.V. Wisgerhof, C. Shackleton, M. Kashgarian, and R.P. Lifton A novel form of human mendelian hypertension featuring nonglucocorticoid-remediable aldosteronism J Clin Endocrinol Metab 93 2008 3117 3123
38. M. Choi, U.I. Scholl, P. Yue, P. Bjorklund, B. Zhao, and C. Nelson-Williams K + channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension Science 331 2011 768 772
39. D.S. Geller, A. Farhi, N. Pinkerton, M. Fradley, M. Moritz, and A. Spitzer Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy Science 289 2000 119 123
40. R.A. Shimkets, R.P. Lifton, and C.M. Canessa The activity of the epithelial sodium channel is regulated by clathrin-mediated endocytosis J Biol Chem 272 1997 25537 25541
41. P.M. Snyder, M.P. Price, F.J. McDonald, C.M. Adams, K.A. Volk, and B.G. Zeiher Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na + channel Cell 83 1995 969 978
42. O. Staub, S. Dho, P. Henry, J. Correa, T. Ishikawa, and J. McGlade WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na + channel deleted in Liddle's syndrome EMBO J 15 1996 2371 2380
43. R.D. Gordon, R.A. Geddes, C.G. Pawsey, and M.W. O'Halloran Hypertension and severe hyperkalaemia associated with suppression of renin and aldosterone and completely reversed by dietary sodium restriction Australas Ann Med 19 1970 287 294
44. K.T. Kahle, A.M. Ring, and R.P. Lifton Molecular physiology of the WNK kinases Annu Rev Physiol 70 2008 329 355
45. T.A. Mansfield, D.B. Simon, Z. Farfel, M. Bia, J.R. Tucci, and M. Lebel Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21 Nat Genet 16 1997 202 205
46. F.H. Wilson, S. Disse-Nicodeme, K.A. Choate, K. Ishikawa, C. Nelson-Williams, and I. Desitter Human hypertension caused by mutations in WNK kinases Science 293 2001 1107 1112
47. R. Birkenhager, E. Otto, M.J. Schurmann, M. Vollmer, E.M. Ruf, and I. Maier-Lutz Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure Nat Genet 29 2001 310 314
48. K. Nozu, T. Inagaki, X.J. Fu, Y. Nozu, H. Kaito, and K. Kanda Molecular analysis of digenic inheritance in Bartter syndrome with sensorineural deafness J Med Genet 45 2008 182 186
49. S. Riazuddin, S. Anwar, M. Fischer, Z.M. Ahmed, S.Y. Khan, and A.G.H. Janssen Molecular basis of DFNB73: mutations of BSND can cause nonsyndromic deafness or Bartter syndrome Am J Hum Genet 85 2009 273 280
50. K.P. Schlingmann, M. Konrad, N. Jeck, P. Waldegger, S.C. Reinalter, and M. Holder Salt wasting and deafness resulting from mutations in two chloride channels N Engl J Med 350 2004 1314 1319
51. D.B. Simon, R.S. Bindra, T.A. Mansfield, C. Nelson-Williams, E. Mendonca, and R. Stone Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III Nat Genet 17 1997 171 178
52. D.B. Simon, F.E. Karet, J.M. Hamdan, A. DiPietro, S.A. Sanjad, and R.P. Lifton Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2 Nat Genet 13 1996 183 188
53. D.B. Simon, F.E. Karet, J. Rodriguez-Soriano, J.H. Hamdan, A. DiPietro, and H. Trachtman Genetic heterogeneity of Bartter's syndrome revealed by mutations in the K + channel, ROMK Nat Genet 14 1996 152 156
54. Y. Mitsuuchi, T. Kawamoto, K. Miyahara, S. Ulick, D.H. Morton, and Y. Naiki Congenitally defective aldosterone biosynthesis in humans: inactivation of the P-450C18 gene (CYP11B2) due to nucleotide deletion in CMO I deficient patients Biochem Biophys Res Commun 190 1993 864 869
55. D.B. Simon, C. Nelson-Williams, M.J. Bia, D. Ellison, F.E. Karet, and A.M. Molina Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter Nat Genet 12 1996 24 30
56. D.S. Geller, J. Rodriguez-Soriano, A. Vallo Boado, S. Schifter, M. Bayer, and S.S. Chang Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I Nat Genet 19 1998 279 281
57. S.S. Chang, S. Grunder, A. Hanukoglu, A. Rosler, P.M. Mathew, and I. Hanukoglu Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1 Nat Genet 12 1996 248 253
58. P.W. Speiser, and P.C. White Congenital adrenal hyperplasia N Engl J Med 349 2003 776 788
59. P.C. White, M.I. New, and B. Dupont Congenital adrenal hyperplasia (2) N Engl J Med 316 1987 1580 1586
60. M. Caulfield, S. Newhouse, and P. Munroe Genetics of essential hypertension D. Khumar, P. Elliot, Clinical cardiovascular genetics 2010 Oxford University Press New York 329 336
61. M. Botero-Velez, J.J. Curtis, and D.G. Warnock Brief report: Liddle's syndrome revisited - a disorder of sodium reabsorption in the distal tubule N Engl J Med 330 1994 178 181
62. J. He, D. Gu, J. Chen, C.E. Jaquish, D.C. Rao, and J.E. Hixson Gender difference in blood pressure responses to dietary sodium intervention in the GenSalt study J Hypertens 27 2009 48 54
63. C. Barlassina, C. Dal Fiume, C. Lanzani, P. Manunta, G. Guffanti, and A. Ruello Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension Hum Mol Genet 16 2007 1630 1638
64. J.Z. Miller, M.H. Weinberger, J.C. Christian, and S.A. Daugherty Familial resemblance in the blood pressure response to sodium restriction Am J Epidemiol 126 1987 822 830
65. L.P. Svetkey, S.P. McKeown, and A.F. Wilson Heritability of salt sensitivity in black Americans Hypertension 28 1996 854 858
66. C. Yagil, M. Sapojnikov, R. Kreutz, G. Katni, K. Lindpaintner, and D. Ganten Salt susceptibility maps to chromosomes 1 and 17 with sex specificity in the Sabra rat model of hypertension Hypertension 31 1998 119 124
67. A.W. Cowley Jr., M. Stoll, A.S. Greene, M.L. Kaldunski, R.J. Roman, and P.J. Tonellato Genetically defined risk of salt sensitivity in an intercross of Brown Norway and Dahl S rats Physiol Genomics 2 2000 107 115
68. Mei H, Gu D, Hixson JE, Rice TK, Chen J, Shimmin LC, Schwander K, Kelly TN, Liu D, Chen S, Huang J, Jaquish CE, Rao DC, He J. Genome-wide linkage and association study of blood pressure response to dietary sodium intervention: The GenSalt Study. Am J Epidemiol. [Accepted]
69. D.R. Dengel, M.D. Brown, R.E. Ferrell, and M.A. Supiano Role of angiotensin converting enzyme genotype in sodium sensitivity in older hypertensives Am J Hypertens 14 2001 1178 1184
70. H. Hiraga, T. Oshima, M. Watanabe, M. Ishida, T. Ishida, and T. Shingu Angiotensin I-converting enzyme gene polymorphism and salt sensitivity in essential hypertension Hypertension 27 1996 569 572
71. E. Poch, D. Gonzalez, V. Giner, E. Bragulat, A. Coca, and A. de La Sierra Molecular basis of salt sensitivity in human hypertension. Evaluation of renin-angiotensin-aldosterone system gene polymorphisms Hypertension 38 2001 1204 1209
72. Q. Zhao, J.E. Hixson, D.C. Rao, D. Gu, C.E. Jaquish, and T.K. Rice Genetic variants in the apelin system and blood pressure responses to dietary sodium interventions: a family-based association study J Hypertens 28 2010 756 763
73. A.G. Johnson, T.V. Nguyen, and D. Davis Blood pressure is linked to salt intake and modulated by the angiotensinogen gene in normotensive and hypertensive elderly subjects J Hypertens 19 2001 1053 1060
74. U. Schorr, K. Blaschke, J. Beige, A. Distler, and A.M. Sharma Angiotensinogen M235T variant and salt sensitivity in young normotensive Caucasians J Hypertens 17 1999 475 479
75. L.P. Svetkey, E.L. Harris, E. Martin, W.M. Vollmer, G.T. Meltesen, and V. Ricchiuti Modulation of the BP response to diet by genes in the renin-angiotensin system and the adrenergic nervous system Am J Hypertens 24 2011 209 217
76. S.C. Hunt, N.R. Cook, A. Oberman, J.A. Cutler, C.H. Hennekens, and P.S. Allender Angiotensinogen genotype, sodium reduction, weight loss, and prevention of hypertension: trials of hypertension prevention, phase II Hypertension 32 1998 393 401
77. S.C. Hunt, J.M. Geleijnse, L.L. Wu, J.C. Witteman, R.R. Williams, and D.E. Grobbee Enhanced blood pressure response to mild sodium reduction in subjects with the 235T variant of the angiotensinogen gene Am J Hypertens 12 1999 460 466
78. T. Norat, R. Bowman, R. Luben, A. Welch, K.T. Khaw, and N. Wareham Blood pressure and interactions between the angiotensin polymorphism AGT M235T and sodium intake: a cross-sectional population study Am J Clin Nutr 88 2008 392 397
79. D. Gu, T.N. Kelly, J.E. Hixson, J. Chen, D. Liu, and J.-c. Chen Genetic variants in the renin-angiotensin-aldosterone system and salt sensitivity of blood pressure J Hypertens 28 2010 1210 1220
80. K. Miyaki, A. Hara, J. Araki, L. Zhang, Y. Song, and T. Kimura C3123A polymorphism of the angiotensin II type 2 receptor gene and salt sensitivity in healthy Japanese men J Hum Hypertens 20 2006 467 469
81. G.T. Cicila, M.R. Garrett, S.J. Lee, J. Liu, H. Dene, and J.P. Rapp High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains Genomics 72 2001 51 60
82. N. Iwai, K. Kajimoto, H. Tomoike, and N. Takashima Polymorphism of CYP11B2 determines salt sensitivity in Japanese Hypertension 49 2007 825 831
83. E. Pamies-Andreu, R. Ramirez-Lorca, P. Stiefel Garcia-Junco, O. Muniz-Grijalbo, I. Vallejo-Maroto, and S. Garcia Morillo Renin-angiotensin- aldosterone system and G-protein beta-3 subunit gene polymorphisms in salt-sensitive essential hypertension J Hum Hypertens 17 2003 187 191
84. A. Wrona, K. Widecka, G. Adler, S. Czekalski, and A. Ciechanowicz Promoter variants of aldosterone synthase gene (CYP11B2) and salt-sensitivity of blood pressure Pol Arch Med Wewn 111 2004 191 197
85. E. Lovati, P. Ferrari, B. Dick, K. Jostarndt, B.M. Frey, and F.J. Frey Molecular basis of human salt sensitivity: the role of the 11beta-hydroxysteroid dehydrogenase type 2 J Clin Endocrinol Metab 84 1999 3745 3749
86. A.K. Agarwal, G. Giacchetti, G. Lavery, H. Nikkila, M. Palermo, and M. Ricketts CA-Repeat polymorphism in intron 1 of HSD11B2: effects on gene expression and salt sensitivity Hypertension 36 2000 187 194
87. M. Adamzik, U.H. Frey, K. Bitzer, H. Jakob, H.A. Baba, and R.E. Schmieder A novel-1364A/C aquaporin 5 gene promoter polymorphism influences the responses to salt loading of the renin-angiotensin-aldosterone system and of blood pressure in young healthy men Basic Res Cardiol 103 2008 598 610
88. Q. Zhao, D. Gu, J.E. Hixson, D. Liu, D.C. Rao, and C.E. Jaquish Common variants in epithelial sodium channel genes contribute to salt-sensitivity of blood pressure: The GenSalt Study Circ Cardiovasc Genet 4 2011 375 380
89. L. Citterio, M. Simonini, L. Zagato, E. Salvi, S. Delli Carpini, and C. Lanzani Genes involved in vasoconstriction and vasodilation system affect salt-sensitive hypertension PLoS One 6 2011 e19620
90. P. Manunta, G. Lavery, C. Lanzani, P.S. Braund, M. Simonini, and C. Bodycote Physiological interaction between alpha-adducin and WNK1-NEDD4L pathways on sodium-related blood pressure regulation Hypertension 52 2008 366 372
91. Y. Osada, R. Miyauchi, T. Goda, N. Kasezawa, H. Horiike, and M. Iida Variations in the WNK1 gene modulates the effect of dietary intake of sodium and potassium on blood pressure determination J Hum Genet 54 2009 474 478
92. A.M. Castejon, J. Bracero, I.S. Hoffmann, A.B. Alfieri, and L.X. Cubeddu NAD(P)H oxidase p22phox gene C242T polymorphism, nitric oxide production, salt sensitivity and cardiovascular risk factors in Hispanics J Hum Hypertens 20 2006 772 779
93. T. Shindo, H. Kurihara, K. Maemura, Y. Kurihara, O. Ueda, and H. Suzuki Renal damage and salt-dependent hypertension in aged transgenic mice overexpressing endothelin-1 J Mol Med 80 2002 105 116
94. J. Caprioli, C. Mele, C. Mossali, L. Gallizioli, G. Giacchetti, and M. Noris Polymorphisms of EDNRB, ATG, and ACE genes in salt-sensitive hypertension Can J Physiol Pharmacol 86 2008 505 510
95. D.R. Dengel, M.D. Brown, R.E. Ferrell, T.H. Reynolds, and M.A. Supiano A preliminary study on T-786C endothelial nitric oxide synthase gene and renal hemodynamic and blood pressure responses to dietary sodium Physiol Res 56 2007 393 401
96. K. Miyaki, S. Tohyama, M. Murata, H. Kikuchi, I. Takei, and K. Watanabe Salt intake affects the relation between hypertension and the T-786C polymorphism in the endothelial nitric oxide synthase gene Am J Hypertens 18 2005 1556 1562
97. E. Beeks, A.G.H. Kessels, A.A. Kroon, M.M. van der Klauw, and P.W. de Leeuw Genetic predisposition to salt-sensitivity: a systematic review J Hypertens 22 2004 1243 1249
98. C. Barlassina, N.J. Schork, P. Manunta, L. Citterio, M. Sciarrone, and G. Lanella Synergistic effect of alpha-adducin and ACE genes causes blood pressure changes with body sodium and volume expansion Kidney Int 57 2000 1083 1090
99. D. Cusi, C. Barlassina, T. Azzani, G. Casari, L. Citterio, and M. Devoto Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension Lancet 349 1997 1353 1357 [Erratum appears in Lancet 1997 Aug 16;350(9076):524]
100. N. Glorioso, P. Manunta, F. Filigheddu, C. Troffa, P. Stella, and C. Barlassina The role of alpha-adducin polymorphism in blood pressure and sodium handling regulation may not be excluded by a negative association study Hypertension 34 1999 649 654
101. F.D. Grant, J.R. Romero, X. Jeunemaitre, S.C. Hunt, P.N. Hopkins, and N.H. Hollenberg Low-renin hypertension, altered sodium homeostasis, and an alpha-adducin polymorphism Hypertension 39 2002 191 196
102. P. Manunta, D. Cusi, C. Barlassina, M. Righetti, C. Lanzani, and M. D'Amico Alpha-adducin polymorphisms and renal sodium handling in essential hypertensive patients Kidney Int 53 1998 1471 1478
103. P. Manunta, M. Maillard, C. Tantardini, M. Simonini, C. Lanzani, and L. Citterio Relationships among endogenous ouabain, alpha-adducin polymorphisms and renal sodium handling in primary hypertension J Hypertens 26 2008 914 920
104. M.T. Sciarrone, P. Stella, C. Barlassina, P. Manunta, C. Lanzani, and G. Bianchi ACE and alpha-adducin polymorphism as markers of individual response to diuretic therapy Hypertension 41 2003 398 403
105. T.N. Kelly, T.K. Rice, D. Gu, J.E. Hixson, J. Chen, and D. Liu Novel genetic variants in the alpha-adducin and guanine nucleotide binding protein beta-polypeptide 3 genes and salt sensitivity of blood pressure Am J Hypertens 22 2009 985 992
106. L. Pojoga, N.S. Kolatkar, J.S. Williams, T.S. Perlstein, X. Jeunemaitre, and N.J. Brown Beta-2 adrenergic receptor diplotype defines a subset of salt-sensitive hypertension Hypertension 48 2006 892 900
107. B. Sun, J.S. Williams, L.P. Svetkey, N.S. Kolatkar, and P.R. Conlin Beta2-adrenergic receptor genotype affects the renin-angiotensin-aldosterone system response to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern Am J Clin Nutr 92 2010 444 449
108. H. Sanada, J. Yatabe, S. Midorikawa, S. Hashimoto, T. Watanabe, and J.H. Moore Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension Clin Chem 52 2006 352 360
109. K. Widecka, A. Ciechanowicz, G. Adler, E. Szychot, M. Wodecki, and S. Czekalski Analysis of polymorphisms Sma (Hpa II) and Sca I gene precursors of atrial natriuretic peptide (ANP) in patients with essential hypertension Pol Arch Med Wewn 100 1998 27 34
110. C.B. Eap, M. Bochud, R.C. Elston, P. Bovet, M.P. Maillard, and J. Nussberger CYP3A5 and ABCB1 genes influence blood pressure and response to treatment, and their effect is modified by salt Hypertension 49 2007 1007 1014
111. M. Bochud, C.B. Eap, R.C. Elston, P. Bovet, M. Maillard, and L. Schild Association of CYP3A5 genotypes with blood pressure and renal function in African families J Hypertens 24 2006 923 929
112. H. Ho, A. Pinto, S.D. Hall, D.A. Flockhart, L. Li, and T.C. Skaar Association between the CYP3A5 genotype and blood pressure Hypertension 45 2005 294 298
113. C. Yagil, N. Hubner, J. Monti, H. Schulz, M. Sapojnikov, and F.C. Luft Identification of hypertension-related genes through an integrated genomic-transcriptomic approach Circ Res 96 2005 617 625
114. Z. Tian, A.S. Greene, K. Usa, I.R. Matus, J. Bauwens, and J.L. Pietrusz Renal regional proteomes in young Dahl salt-sensitive rats Hypertension 51 2008 899 904
115. R.J. Havlik Predictors of hypertension. Population studies Am J Hypertens 4 1991 586S 589S
116. H. Castrop, and A. Kurtz Differential nNOS gene expression in salt-sensitive and salt-resistant Dahl rats J Hypertens 19 2001 1223 1231
117. C. Fava, E. Danese, M. Montagnana, M. Sjogren, P. Almgren, and G. Engstrom Serine/threonine kinase 39 is a candidate gene for primary hypertension especially in women: results from two cohort studies in Swedes J Hypertens 29 2011 484 491
118. S. Kojima, T. Inenaga, H. Matsuoka, M. Kuramochi, T. Omae, and Y. Nara The association between salt sensitivity of blood pressure and some polymorphic factors J Hypertens 12 1994 797 801
119. E. Brand, U. Schorr, J. Ringel, J. Beige, A. Distler, and A.M. Sharma Aldosterone synthase gene (CYP11B2) C-344T polymorphism in Caucasians from the Berlin Salt-Sensitivity Trial (BeSST) J Hypertens 17 1999 1563 1567
120. H. Oberleithner, K. Kusche-Vihrog, and H. Schillers Endothelial cells as vascular salt sensors Kidney Int 77 2010 490 494
121. N. Toda, and K. Arakawa Salt-induced hemodynamic regulation mediated by nitric oxide J Hypertens 29 2011 415 424
122. U. Schorr, J. Beige, J. Ringel, S. Turan, R. Kreutz, and A. Distler Hpa II polymorphism of the atrial natriuretic peptide gene and the blood pressure response to salt intake in normotensive men J Hypertens 15 1997 715 718
123. A.M. Castejon, A.B. Alfieri, I.S. Hoffmann, A. Rathinavelu, and L.X. Cubeddu Alpha-adducin polymorphism, salt sensitivity, nitric oxide excretion, and cardiovascular risk factors in normotensive Hispanics Am J Hypertens 16 2003 1018 1024
124. A. Ciechanowicz, K. Widecka, R. Drozd, G. Adler, L. Cyrylowski, and S. Czekalski Lack of association between Gly460Trp polymorphism of alpha-adducin gene and salt sensitivity of blood pressure in Polish hypertensives Kidney Blood Press Res 24 2001 201 206
125. G.F. DiBona Sympathetic nervous system and the kidney in hypertension Curr Opin Nephrol Hypertens 11 2002 197 200
126. A. Stella, and A. Zanchetti Interactions between the sympathetic nervous system and the kidney: experimental observations J Hypertens Suppl 3 1985 S19 S25
127. A. Reaux, N. De Mota, I. Skultetyova, Z. Lenkei, S. El Messari, and K. Gallatz Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain J Neurochem 77 2001 1085 1096
128. W.-W. Li, W.-Q. Niu, Y. Zhang, S. Wu, P.-J. Gao, and D.-L. Zhu Family-based analysis of apelin and AGTRL1 gene polymorphisms with hypertension in Han Chinese J Hypertens 27 2009 1194 1201
129. L.G. Melo, A.T. Veress, C.K. Chong, S.C. Pang, T.G. Flynn, and H. Sonnenberg Salt-sensitive hypertension in ANP knockout mice: potential role of abnormal plasma renin activity Am J Physiol 274 1998 R255 R261
130. K.L. Ellis, C. Newton-Cheh, T.J. Wang, C.M. Frampton, R.N. Doughty, and G.A. Whalley Association of genetic variation in the natriuretic peptide system with cardiovascular outcomes J Mol Cell Cardiol 50 2011 695 701
131. S.W. John, J.H. Krege, P.M. Oliver, J.R. Hagaman, J.B. Hodgin, and S.C. Pang Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension Science 267 1995 679 681 [Erratum appears in Science 1995 Mar 24;267(5205):1753]
132. C. Newton-Cheh, M.G. Larson, R.S. Vasan, D. Levy, K.D. Bloch, and A. Surti Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure Nat Genet 41 2009 348 353
133. P. Madeddu, M.V. Varoni, M.P. Demontis, J. Chao, J.A. Simson, and N. Glorioso Kallikrein-kinin system and blood pressure sensitivity to salt Hypertension 29 1997 471 477
134. P. Madeddu, M.V. Varoni, M.P. Demontis, P. Pinna-Parpaglia, N. Glorioso, and V. Anania Urinary kallikrein: a marker of blood pressure sensitivity to salt Kidney Int 49 1996 1422 1427
135. G. Bonner, B. Thieven, H. Rutten, R. Chrosch, and W. Krone Renal kallikrein is a determinant of salt sensitivity J Hypertens Suppl 11 1993 S210 S211
136. J. Cohen, A. Pertsemlidis, I.K. Kotowski, R. Graham, C.K. Garcia, and H.H. Hobbs Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9 Nat Genet 37 2005 161 165 [Erratum appears in Nat Genet 2005 Mar;37(3):328]
137. J.C. Cohen, R.S. Kiss, A. Pertsemlidis, Y.L. Marcel, R. McPherson, and H.H. Hobbs Multiple rare alleles contribute to low plasma levels of HDL cholesterol Science 305 2004 869 872
138. J.C. Cohen, A. Pertsemlidis, S. Fahmi, S. Esmail, G.L. Vega, and S.M. Grundy Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels Proc Natl Acad Sci USA 103 2006 1810 1815
139. J.C. Cohen, E. Boerwinkle, T.H. Mosley Jr., and H.H. Hobbs Sequence variations in PCSK9, low LDL, and protection against coronary heart disease N Engl J Med 354 2006 1264 1272
140. W. Ji, J.N. Foo, B.J. O'Roak, H. Zhao, M.G. Larson, and D.B. Simon Rare independent mutations in renal salt handling genes contribute to blood pressure variation Nat Genet 40 2008 592 599