Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1α-mediated mRNA transcription and continuous protein synthesis

FASEB Journal

Volumn 26, Issue 6, 2012, Pages 2620-2630

  Natsuizaka, Mitsuteru ^a,b   Naganuma, Seiji ^a,b   Kagawa, Shingo ^a,b   Ohashi, Shinya ^a,b,d   Ahmadi, Azal ^a,b   Subramanian, Harry ^a,b   Chang, Sanders ^a,b   Nakagawa, Kei J ^a,b   Ji, Xinjun ^a   Liebhaber, Stephen A ^a   Klein Szanto, Andres J ^c   Nakagawa, Hiroshi ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c FOX CHASE CANCER CENTER   (United States)

^d Kitano Hospital   (Japan)

Author keywords

Cap dependent translation; Internal ribosome entry site

Indexed keywords

BETA ACTIN; GUANOSINE TRIPHOSPHATE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; SOMATOMEDIN BINDING PROTEIN 3;

5' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME ACTIVITY; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; GENE LOCATION; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; KERATINIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; RNA INTERFERENCE; RNA TRANSCRIPTION; RNA TRANSLATION; TUMOR MICROENVIRONMENT; UPREGULATION;

ANIMALS; ANOXIA; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; ESOPHAGEAL NEOPLASMS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; MICE; NEOPLASM TRANSPLANTATION; POLYRIBOSOMES; PROTEIN BIOSYNTHESIS; RNA CAP ANALOGS; RNA CAPS; RNA, MESSENGER; TOR SERINE-THREONINE KINASES; TRANSCRIPTION, GENETIC; TRANSPLANTATION, HETEROLOGOUS;

MAMMALIA;

EID: 84861778563     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-198598     Document Type: Article

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