ATP released from cardiac fibroblasts via connexin hemichannels activates profibrotic P2Y2 receptors

FASEB Journal

Volumn 26, Issue 6, 2012, Pages 2580-2591

  Lu, David ^a   Soleymani, Sahar ^a   Madakshire, Rohit ^a   Insel, Paul A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

smooth muscle actin; Cardiac fibrosis; Extracellular matrix; MAPK ERK activation; Purinergic signaling

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ADENOSINE TRIPHOSPHATE; ALPHA SMOOTH MUSCLE ACTIN; APYRASE; BREFELDIN A; CARBENOXOLONE; COLLAGEN; CONNEXIN 43; CONNEXIN 45; GAP JUNCTION PROTEIN; MATRIX METALLOPROTEINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROBENECID; PURINERGIC P2Y2 RECEPTOR; SURAMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIAC FIBROBLAST; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FIBROBLAST; GENE EXPRESSION; GENE SILENCING; HEART MUSCLE FIBROSIS; HOMEOSTASIS; INTRACELLULAR SIGNALING; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; PROTEIN SECRETION; RAT;

ACTINS; ADENOSINE TRIPHOSPHATE; ANIMALS; APYRASE; CALCIUM; CHEMOKINE CCL2; COLLAGEN; CONNEXIN 43; CONNEXINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; HYPOTONIC SOLUTIONS; MALE; MAP KINASE SIGNALING SYSTEM; MYOCARDIUM; PLASMINOGEN ACTIVATOR INHIBITOR 1; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2Y2;

EID: 84861765275     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-204677     Document Type: Article

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