The role of proteomics in depression research

European Archives of Psychiatry and Clinical Neuroscience

Volumn 260, Issue 6, 2010, Pages 499-506

  Martins De Souza, Daniel ^a   Harris, Laura W ^b   Guest, Paul C ^b   Turck, Christoph W ^a   Bahn, Sabine ^b  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Clinical MDD; Major depressive disorder (MDD); Proteomics; Unipolar MDD

Indexed keywords

2',3' CYCLIC NUCLEOTIDE 3' PHOSPHODIESTERASE; ACONITATE HYDRATASE; ALDOLASE C; APOLIPOPROTEIN A1; APOLIPOPROTEIN A2; APOLIPOPROTEIN A4; BRAIN DERIVED NEUROTROPHIC FACTOR; COLLAPSIN RESPONSE MEDIATOR PROTEIN 2; FLUOXETINE; GLIAL FIBRILLARY ACID PROTEIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEXOKINASE; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; N ACETYLASPARTIC ACID; NEUROKININ; NEUROKININ 1; NEURON SPECIFIC ENOLASE; NORADRENALIN; PROTEIN; PUTRESCINE; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SEROTONIN; SPERMIDINE; TRANSFERRIN; UNCLASSIFIED DRUG; VENLAFAXINE;

ARTICLE; BIPOLAR DISORDER; BRAIN; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE METABOLISM; GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID CHROMATOGRAPHY; MAJOR DEPRESSION; MASS SPECTROMETRY; MEDICAL RESEARCH; METABOLOMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOMICS; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SCHIZOPHRENIA; TANDEM MASS SPECTROMETRY; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING;

ANIMALS; ANTIDEPRESSIVE AGENTS; BIOLOGICAL MARKERS; CITALOPRAM; DEPRESSIVE DISORDER; DISEASE MODELS, ANIMAL; DRUG RESISTANCE; HUMANS; MICE; NUCLEUS ACCUMBENS; PROTEOME; PROTEOMICS; SEROTONIN UPTAKE INHIBITORS;

EID: 77956908959     PISSN: 09401334     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00406-009-0093-2     Document Type: Article

References (77)

1. M Aan Het Rot SJ Mathew DS Charney 2009 Neurobiological mechanisms in major depressive disorder CMAJ 180 3 305 313 19188629
2. CL Beasley K Pennington A Behan R Wait MJ Dunn D Cotter 2006 Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: evidence for disease-associated changes Proteomics 6 3414 3425 1:CAS:528:DC%2BD28Xmt1artLY%3D 10.1002/pmic.200500069 16637010 (Pubitemid 43886157)
3. A Behan C Byrne MJ Dunn G Cagney DR Cotter 2009 Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression Mol Psychiatry 14 601 613 1:CAS:528: DC%2BD1MXmtVKnsLc%3D 10.1038/mp.2008.7 18268500
4. D Ben-Shachar 2002 Mitochondrial dysfunction in schizophrenia: a possible linkage to dopamine J Neurochem 83 1241 1251 1:CAS:528:DC%2BD3sXjsFGr 10.1046/j.1471-4159.2002.01263.x 12472879 (Pubitemid 35477464)
5. JD Berke SE Hyman 2000 Addiction, dopamine, and the molecular mechanisms of memory Neuron 25 3 515 532 1:CAS:528:DC%2BD3cXisFKrtLw%3D 10.1016/S0896-6273(00)81056-9 10774721 (review)
6. GP Bertenshaw P Yip P Seshaiah J Zhao TH Chen, et al. 2008 Multianalyte profiling of serum antigens and autoimmune and infectious disease molecules to identify biomarkers dysregulated in epithelial ovarian cancer Cancer Epidemiol Biomarkers Prev 17 10 2872 2881 1:CAS:528:DC%2BD1cXht1egt7nM 10.1158/1055-9965.EPI-08-0464 18843033
7. CF Bisgaard MN Jayatissa JJ Enghild C Sanchéz R Artemychyn O Wiborg 2007 Proteomic investigation of the ventral rat hippocampus links DRP-2 to escitalopram treatment resistance and SNAP to stress resilience in the chronic mild stress model of depression J Mol Neurosci 32 2 132 144 1:CAS:528:DC%2BD2sXns1OqtrY%3D 10.1007/s12031-007-0025-4 17873297 (Pubitemid 47460449)
8. PV Choudary M Molnar SJ Evans H Tomita JZ Li MP Vawter, et al. 2005 Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression Proc Natl Acad Sci USA 102 15653 15658 1:CAS:528:DC%2BD2MXht1ShtrfM 10.1073/pnas.0507901102 16230605 (Pubitemid 41528111)
9. D Clark I Dedova S Cordwell I Matsumoto 2006 A proteome analysis of the anterior cingulate cortex gray matter in schizophrenia Mol Psychiatry 11 459 470 1:CAS:528:DC%2BD28XjslKksrg%3D 10.1038/sj.mp.4001806 16491132
10. N Delaleu H Immervoll J Cornelius R Jonsson 2008 Biomarker profiles in serum and saliva of experimental Sjogren's syndrome: associations with specific autoimmune manifestations Arthritis Res Ther 10 1 R22 10.1186/ar2375 18289371 (Pubitemid 351386985)
11. MR DiMatteo HS Lepper TW Croghan 2000 Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence Arch Intern Med 160 2101 2107 1:STN:280:DC%2BD3czptVKgug%3D%3D 10.1001/archinte.160.14.2101 10904452
12. Ditzen C, Varadarajulu J, Czibere L, Gonik M, Targosz BS et al (2009) Proteomic-based genotyping in a mouse model of trait anxiety exposes disease-relevant pathways. Mol Psychiatry [Epub ahead of print]
13. MR Drew R Hen 2007 Adult hippocampal neurogenesis as target for the treatment of depression CNS Neurol Disord Drug Targets 6 205 218 1:CAS:528:DC%2BD2sXltValtLg%3D 10.2174/187152707780619353 17511617
14. Y Du CF Dreyfus 2006 Oligodendrocytes as providers of growth factors J Neurosci Res 68 647 654 10.1002/jnr.10245
15. H Duan J Fleming DK Pritchard LM Amon J Xue, et al. 2008 Combined analysis of monocyte and lymphocyte messenger RNA expression with serum protein profiles in patients with scleroderma Arthritis Rheum 58 5 1465 1474 1:CAS:528:DC%2BD1cXms1egsrg%3D 10.1002/art.23451 18438864 (Pubitemid 351705936)
16. RS Duman J Malberg S Nakagawa C D'Sa 2000 Neuronal plasticity and survival in mood disorders Biol Psychiatry 48 732 739 1:STN:280: DC%2BD3crht1SitQ%3D%3D 10.1016/S0006-3223(00)00935-5 11063970
17. JA English P Dicker M Föcking MJ Dunn DR Cotter 2009 2-D DIGE analysis implicates cytoskeletal abnormalities in psychiatric disease Proteomics 9 3368 3382 1:CAS:528:DC%2BD1MXotFCnurg%3D 10.1002/pmic.200900015 19562803
18. GP Escobar ML Lindsey 2007 Multi-analyte profiling of post-myocardial infarction plasma samples FASEB J 21 746.11
19. K Fabel K Fabel B Tam D Kaufer A Baiker, et al. 2003 VEGF is necessary for exercise-induced adult hippocampal neurogenesis Eur J Neurosci 18 10 2803 2812 10.1111/j.1460-9568.2003.03041.x 14656329 (Pubitemid 37542133)
20. J Foong M Maier GJ Barker S Brocklehurst DH Miller MA Ron 2000 In vivo investigation of white matter pathology in schizophrenia with magnetization transfer imaging J Neurol Neurosurg Psychiatry 68 70 74 1:STN:280: DC%2BD3c%2FmvF2ktw%3D%3D 10.1136/jnnp.68.1.70 10601405 (Pubitemid 30248662)
21. E Gould 1999 Serotonin and hippocampal neurogenesis Neuropsychopharmacology 21 46S 51S 1:CAS:528:DyaK1MXltVOntL0%3D 10432488
22. PC Guest MR Knowles S Molon-Noblot K Salim D Smith, et al. 2004 Mechanisms of action of the antidepressants fluoxetine and the substance P antagonist L-000760735 are associated with altered neurofilaments and synaptic remodeling Brain Res 1002 1-2 1 10 1:CAS:528:DC%2BD2cXhsVOms7g%3D 10.1016/j.brainres.2003.11.064 14988027 (Pubitemid 38251573)
23. PA Gurbel RP Kreutz KP Bliden J DiChiara US Tantry 2008 Biomarker analysis by fluorokine multianalyte profiling distinguishes patients requiring intervention from patients with long-term quiescent coronary artery disease: a potential approach to identify atherosclerotic disease progression Am Heart J 155 1 56 61 1:CAS:528:DC%2BD2sXhsVenurnP 10.1016/j.ahj.2007.08.021 18082490 (Pubitemid 350234773)
24. SP Gygi GL Corthals Y Zhang Y Rochon R Aebersold 2000 Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology Proc Natl Acad Sci USA 97 17 9390 9395 1:CAS:528:DC%2BD3cXmtVensrs%3D 10.1073/pnas.160270797 10920198
25. Harris LJW, Swatton JE, Wengenroth M, Wayland M, Lockstone HE, Holland A, Faull RLM, Lilley KS, Bahn S (2007) Differences in protein profiles in schizophrenia prefrontal cortex compared to other major brain disorders. Clin Schizophrenia Relat Psychoses 1:21-39
26. PJ Harrison 2002 The neuropathology of primary mood disorder Brain 125 Pt 7 1428 1449 10.1093/brain/awf149 12076995
27. EA Hazlett MS Buchsbaum W Byne TC Wei J Spiegel-Cohen, et al. 1999 Three-dimensional analysis with MRI and PET of the size, shape, and function of the thalamus in the schizophrenia spectrum Am J Psychiatry 156 1190 1199 1:STN:280:DyaK1MznvVOmsQ%3D%3D 10450259
28. MS Henniger F Ohl SM Holter P Weissenbacher N Toschi, et al. 2000 Unconditioned anxiety and social behaviour in two rat lines selectively bred for high and low anxiety-related behaviour Behav Brain Res 111 153 163 1:STN:280:DC%2BD3czotlCktA%3D%3D 10.1016/S0166-4328(00)00151-0 10840141 (Pubitemid 30326711)
29. JT Huang FM Leweke D Oxley L Wang N Harris, et al. 2006 Disease biomarkers in cerebrospinal fluid of patients with first-onset psychosis PLoS Med 3 11 e428 10.1371/journal.pmed.0030428 17090210 (Pubitemid 44875947)
30. JT Huang L Wang S Prabakaran M Wengenroth HE Lockstone, et al. 2008 Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissues Mol Psychiatry 13 12 1118 1128 1:CAS:528:DC%2BD1cXhtlOjtr%2FM 10.1038/sj.mp.4002108 17938634
31. NL Johnston-Wilson CD Sims JP Hofmann L Anderson AD Shore, et al. 2000 Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium Mol Psychiatry 5 142 149 1:CAS:528:DC%2BD3cXlslartrg%3D 10.1038/sj.mp.4000696 10822341
32. X Khawaja J Xu JJ Liang JE Barrett 2004 Proteomic analysis of protein changes developing in rat hippocampus after chronic antidepressant treatment: implications for depressive disorders and future therapies J Neurosci Res 75 4 451 460 1:CAS:528:DC%2BD2cXhsFKhu7c%3D 10.1002/jnr.10869 14743428 (Pubitemid 38160706)
33. S Kim KH Choi AF Baykiz HK Gershenfeld 2007 Suicide candidate genes associated with bipolar disorder and schizophrenia: an exploratory gene expression profiling analysis of post-mortem prefrontal cortex BMC Genom 8 413 10.1186/1471-2164-8-413
34. TA Klempan A Sequeira L Canetti A Lalovic C Ernst, et al. 2009 Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression Mol Psychiatry 14 2 175 189 1:CAS:528:DC%2BD1MXotVejtQ%3D%3D 10.1038/sj.mp.4002110 17938633
35. SA Krömer MS Kessler D Milfay IN Birg M Bunck, et al. 2005 Identification of glyoxalase-I as a protein marker in a mouse model of extremes in trait anxiety J Neurosci 25 17 4375 4384 10.1523/JNEUROSCI.0115-05.2005 15858064 (Pubitemid 40628782)
36. M Kubicki H Park CF Westin PG Nestor RV Mulkern, et al. 2005 DTI and MTR abnormalities in schizophrenia: analysis of white matter integrity Neuroimage 15 1109 1118 10.1016/j.neuroimage.2005.03.026 (Pubitemid 40806489)
37. VA Kulkarni S Jha VA Vaidya 2002 Depletion of norepinephrine decreases the proliferation, but does not influence the survival and differentiation, of granule cell progenitors in the adult rat hippocampus Eur J Neurosci 16 2008 2012 10.1046/j.1460-9568.2002.02268.x 12453065 (Pubitemid 37059588)
38. A Lalovic E Levy L Canetti A Sequeira A Montoudis G Turecki 2007 Fatty acid composition in postmortem brains of people who completed suicide J Psychiatry Neurosci 32 5 363 370 17823652
39. A Lalovic E Levy G Luheshi L Canetti E Grenier, et al. 2007 Cholesterol content in brains of suicide completers Int J Neuropsychopharmacol 10 2 159 166 1:CAS:528:DC%2BD2sXhs1Cqs7k%3D 10.1017/S1461145706006663 16707033
40. Lalovic A, Klempan T, Sequeira A, Luheshi G, Turecki G (2009) Altered expression of lipid metabolism and immune response genes in the frontal cortex of suicide completers. J Affect Disord [Epub ahead of print]
41. J Lee W Duan MP Mattson 2002 Evidence that brain derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus during contextual learning J Neurochem 82 1367 1375 1:CAS:528:DC%2BD38XnsV2hsro%3D 10.1046/j.1471-4159.2002.01085.x 12354284
42. SP Lee KI Ataga M Zayed JM Manganello EP Orringer, et al. 2007 Phase I study of eptifibatide in patients with sickle cell anaemia Br J Haematol 139 4 612 620 1:CAS:528:DC%2BD2sXhsVyjurbM 10.1111/j.1365-2141.2007.06787.x 17916103 (Pubitemid 350043807)
43. Levin Y, Wang L, Schwarz E, Koethe D, Leweke FM, Bahn S (2009) Global proteomic profiling reveals altered proteomic signature in schizophrenia serum. Mol Psychiatry [Epub ahead of print]
44. AJ Link J Eng DM Schieltz E Carmack GJ Mize, et al. 1999 Direct analysis of protein complexes using mass spectrometry Nat Biotechnol 17 7 676 682 1:CAS:528:DyaK1MXksFehsLc%3D 10.1038/10890 10404161 (Pubitemid 29316146)
45. JE Malberg AJ Eisch EJ Nestler RS Duman 2000 Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus J Neurosci 20 9104 9110 1:CAS:528:DC%2BD3MXis1SqsA%3D%3D 11124987
46. D Martins-de-Souza WF Gattaz A Schmitt G Maccarrone E Hunyadi-Gulyás, et al. 2009 Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia J Psychiatr Res 43 978 986 10.1016/j.jpsychires.2008.11.006 19110265
47. D Martins-de-Souza WF Gattaz A Schmitt C Rewerts S Marangoni, et al. 2009 Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis J Neural Transm 116 275 289 1:CAS:528:DC%2BD1MXis12jtLc%3D 10.1007/s00702-008-0156-y 19034380
48. D Martins-de-Souza WF Gattaz A Schmitt C Rewerts G Maccarrone, et al. 2009 Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia Eur Arch Psychiatry Clin Neurosci 259 151 163 10.1007/s00406-008-0847-2 19165527
49. D Martins-de-Souza WF Gattaz A Schmitt JC Novello S Marangoni, et al. 2009 Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation BMC Psychiatry 9 17 10.1186/1471-244X-9-17 19405953
50. D Martins-de-Souza 2009 Proteomics is not only a biomarker discovery tool Proteomics Clin Appl 3 1136 1139 1:CAS:528:DC%2BD1MXht1Kis7zE 10.1002/prca.200900096
51. Martins-de-Souza D, Maccarrone G, Wobrock T, Zerr I, Gormanns P et al (2010) Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers for schizophrenia. J Neurosci (submitted)
52. Martins-de-Souza D, Dias-Neto E, Schmitt A, Falkai P, Gormanns P et al (2010) Proteome analysis of schizophrenia brain tissue. World J Biol Psychiatry (in press)
53. MC McKinnon K Yucel A Nazarov GM MacQueen 2009 A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder J Psychiatry Neurosci 34 1 41 54 19125212
54. GA McLoughlin D Ma TM Tsang DN Jones J Cilia, et al. 2009 Analyzing the effects of psychotropic drugs on metabolite profiles in rat brain using 1H NMR spectroscopy J Proteome Res 8 4 1943 1952 1:CAS:528:DC%2BD1MXivFOmtbs%3D 10.1021/pr800892u 19714815
55. S Morcuende CA Gadd M Peters A Moss EA Harris, et al. 2003 Increased neurogenesis and brain-derived neurotrophic factor in neurokinin-1 receptor gene knockout mice Eur J Neurosci 18 7 1828 1836 10.1046/j.1460-9568.2003.02911.x 14622216 (Pubitemid 37372366)
56. J Mu P Xie ZS Yang DL Yang FJ Lv, et al. 2007 Neurogenesis and major depression: implications from proteomic analyses of hippocampal proteins in a rat depression model Neurosci Lett 416 3 252 256 1:CAS:528:DC%2BD2sXjslSqtLk%3D 10.1016/j.neulet.2007.01.067 17368938 (Pubitemid 46505186)
57. M Nibuya S Morinobu RS Duman 1995 Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments J Neurosci 15 7539 7547 1:CAS:528:DyaK2MXptlOmsLk%3D 7472505
58. SI Novikova F He NJ Cutrufello MS Lidow 2006 Identification of protein biomarkers for schizophrenia and bipolar disorder in the postmortem prefrontal cortex using SELDI-TOF-MS ProteinChip profiling combined with MALDI-TOF-PSD-MS analysis Neurobiol Dis 23 1 61 76 1:CAS:528:DC%2BD28XlvFyqtLc%3D 10.1016/j.nbd.2006.02.002 16549361 (Pubitemid 44192384)
59. K Pennington P Dicker MJ Dunn DR Cotter 2008 Proteomic analysis reveals protein changes within layer 2 of the insular cortex in schizophrenia Proteomics 8 5097 5107 1:CAS:528:DC%2BD1MXlsFentA%3D%3D 10.1002/pmic.200800415 19003868
60. S Prabakaran JE Swatton MM Ryan SJ Huffaker JT Huang, et al. 2004 Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress Mol Psychiatry 9 684 697 1:CAS:528: DC%2BD2cXltFWntLs%3D 10.1038/sj.mp.4001532 15098003 643 (Pubitemid 38932169)
61. S Prabakaran M Wengenroth HE Lockstone K Lilley FM Leweke S Bahn 2007 2-D DIGE analysis of liver and red blood cells provides further evidence for oxidative stress in schizophrenia J Proteome Res 6 141 149 1:CAS:528: DC%2BD28Xht12nsbfL 10.1021/pr060308a 17203958 (Pubitemid 46173666)
62. S Rosenzweig-Lipson, et al. 2007 Differentiating antidepressants of the future: efficacy and safety Pharmacol Ther 113 134 153 1:CAS:528: DC%2BD2sXhsFCktQ%3D%3D 10.1016/j.pharmthera.2006.07.002 17010443 (Pubitemid 46017069)
63. K Salim L Kehoe MS Minkoff JG Bilsland I Munoz-Sanjuan PC Guest 2006 Identification of differentiating neural progenitor cell markers using shotgun isobaric tagging mass spectrometry Stem Cells Dev 15 3 461 470 1:CAS:528:DC%2BD28XmvFSltbo%3D 10.1089/scd.2006.15.461 16846381 (Pubitemid 44100021)
64. A Sequeira T Klempan L Canetti J ffrench-Mullen C Benkelfat, et al. 2007 Patterns of gene expression in the limbic system of suicides with and without major depression Mol Psychiatry 12 7 640 655 1:CAS:528:DC%2BD2sXmvV2nsLY%3D 10.1038/sj.mp.4001969 17353912 (Pubitemid 46998251)
65. A Sequeira F Mamdani C Ernst MP Vawter WE Bunney, et al. 2009 Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression PLoS One 4 8 e6585 10.1371/journal.pone.0006585 19668376
66. YI Sheline PW Wang MH Gado JG Csernansky MW Vannier 1996 Hippocampal atrophy in recurrent major depression Proc Natl Acad Sci USA 93 3908 3913 1:CAS:528:DyaK28XivVKrt7k%3D 10.1073/pnas.93.9.3908 8632988 (Pubitemid 26144221)
67. Y Shirayama ACH Chen S Nakagawa DS Russell RS Duman 2002 Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression J Neurosci 22 3251 3261 1:CAS:528:DC%2BD38XjtF2gtLw%3D 11943826
68. E Sibille V Arango HC Galfalvy P Pavlidis L Erraji-Benchekroun, et al. 2004 Gene expression profiling of depression and suicide in human prefrontal cortex Neuropsychopharmacology 29 2 351 361 1:CAS:528:DC%2BD2cXksl2hug%3D%3D 10.1038/sj.npp.1300335 14603265 (Pubitemid 38175153)
69. S Sivagnanasundaram B Crossett I Dedova S Cordwell I Matsumoto 2007 Abnormal pathways in the genu of the corpus callosum in schizophrenia pathogenesis: a proteome study Proteomics Clin Appl 1 1291 1305 1:CAS:528:DC%2BD2sXht1Kqsb7K 10.1002/prca.200700230
70. Skolnick P, Popik P, Trullas R (2009) Glutamate-based antidepressants: 20 years on. Trends Pharmacol Sci [Epub ahead of print]
71. HA Skynner DP Amos F Murray K Salim MR Knowles, et al. 2006 Proteomic analysis identifies alterations in cellular morphology and cell death pathways in mouse brain after chronic corticosterone treatment Brain Res 1102 1 12 26 1:CAS:528:DC%2BD28XntlWiu78%3D 10.1016/j.brainres.2006.04.112 16797492 (Pubitemid 44092660)
72. R Sultana D Boyd-Kimball J Cai WM Pierce JB Klein, et al. 2007 Proteomics analysis of the Alzheimer's disease hippocampal proteome J Alzheimers Dis 11 2 153 164 1:CAS:528:DC%2BD2sXlsVCitLs%3D 17522440
73. CA Tamminga GK Thaker R Buchanan B Kirkpatrick LD Alphs, et al. 1992 Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome Arch Gen Psychiatry 49 522 530 1:STN:280:DyaK38zivVKgtA%3D%3D 1627043
74. M Thambisetty A Hye C Foy E Daly A Glover, et al. 2008 Proteome-based identification of plasma proteins associated with hippocampal metabolism in early Alzheimer's disease J Neurol 255 11 1712 1720 1:CAS:528: DC%2BD1MXht1emsr4%3D 10.1007/s00415-008-0006-8 19156487
75. MR Wilkins JC Sanchez AA Gooley RD Appel I Humphery-Smith, et al. 1996 Progress with proteome projects: why all proteins expressed by a genome should be identified and how to do it Biotechnol Genet Eng Rev 13 19 50 1:CAS:528:DyaK28XkvVWks7s%3D 8948108
76. World Health Organization (2001) The World Health Report 2001: mental health: new understanding, new hope. World Health Organization, Geneva, p 169
77. JK Yao RD Reddy DP van Kammen 2001 Oxidative damage and schizophrenia: an overview of the evidence and its therapeutic implications CNS Drugs 15 287 310 1:CAS:528:DC%2BD3MXjs12nsb0%3D 10.2165/00023210-200115040-00004 11463134