Anti-amyloidogenic effects of soybean isoflavones in vitro: Fluorescence spectroscopy demonstrating direct binding to Aβ monomers, oligomers and fibrils

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1822, Issue 8, 2012, Pages 1316-1324

  Hirohata, Mie ^a,b   Ono, Kenjiro ^a   Takasaki, Jun ichi ^a   Takahashi, Ryoichi ^a   Ikeda, Tokuhei ^a   Morinaga, Akiyoshi ^a   Yamada, Masahito ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^b National Hospital Organization Nanao Hospital   (Japan)

Author keywords

Alzheimer's disease; Amyloid protein oligomer; Fragment; Glycitein; Photo induced cross linking of unmodified proteins (PICUP); Three dimensional fluorescence spectroscopy

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID BETA PROTEIN[25-35]; DAIZEIN; EQUOL; FORMONONETIN; GENISTEIN; GLYCITEIN; ISOFLAVONE DERIVATIVE; MONOMER; OLIGOMER; PURUNETIN; THIOFLAVINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; ATOMIC FORCE MICROSCOPY; CONTROLLED STUDY; ELECTRON MICROSCOPY; FIBER; FLUORESCENCE; FLUORESCENCE SPECTROSCOPY; GEL PERMEATION CHROMATOGRAPHY; NONHUMAN; OLIGOMERIZATION; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN MODIFICATION; PROTEIN POLYMERIZATION; PROTEIN STABILITY; SOYBEAN; TEMPERATURE;

AMYLOID BETA-PEPTIDES; HUMANS; ISOFLAVONES; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON; PEPTIDE FRAGMENTS; SOYBEANS; SPECTROMETRY, FLUORESCENCE; THIAZOLES;

GLYCINE MAX;

EID: 84861679970     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2012.05.006     Document Type: Article

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