Inhibition of cyclooxygenase-1 lowers proliferation and induces macroautophagy in colon cancer cells

Biochemical and Biophysical Research Communications

Volumn 382, Issue 1, 2009, Pages 79-84

  Wu, William Ka Kei ^a,b   Sung, Joseph Jao Yiu ^a   Wu, Ya Chun ^b   Li, Hai To ^b   Yu, Le ^a,b   Li, Zhi Jie ^b   Cho, Chi Hin ^a,b  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Cell cycle; Colon cancer; Cyclooxygenase 1; Macroautophagy; Proliferation

Indexed keywords

3 METHYLADENINE; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN E; CYCLOOXYGENASE 1 INHIBITOR; DANSYLCADAVERINE; LACTATE DEHYDROGENASE; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN C FOS; TRANSCRIPTION FACTOR E2F1;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER INHIBITION; CELL CYCLE ARREST; CELL PROLIFERATION; CELL STRAIN HT29; COLON CANCER; COLONY FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CONTENT; DRUG EFFECT; ENZYME PHOSPHORYLATION; ENZYME RELEASE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ADENINE; AUTOPHAGY; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; CYCLOOXYGENASE 1; CYCLOOXYGENASE INHIBITORS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; PYRAZOLES; VACUOLES;

EID: 63149187087     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.02.140     Document Type: Article

References (24)

1. Chulada P.C., Thompson M.B., Mahler J.F., Doyle C.M., Gaul B.W., Lee C., Tiano H.F., Morham S.G., Smithies O., and Langenbach R. Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res. 60 (2000) 4705-4708
2. Kitamura T., Kawamori T., Uchiya N., Itoh M., Noda T., Matsuura M., Sugimura T., and Wakabayashi K. Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis. Carcinogenesis 23 (2002) 1463-1466
3. Niho N., Kitamura T., Takahashi M., Mutoh M., Sato H., Matsuura M., Sugimura T., and Wakabayashi K. Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor. Cancer Sci. 97 (2006) 1011-1014
4. Riehl T.E., George R.J., Sturmoski M.A., May R., Dieckgraefe B., Anant S., and Houchen C.W. Azoxymethane protects intestinal stem cells and reduces crypt epithelial mitosis through a COX-1-dependent mechanism. Am. J. Physiol. Gastrointest. Liver Physiol. 291 (2006) G1062-G1070
5. Giardiello F.M., Hamilton S.R., Krush A.J., Piantadosi S., Hylind L.M., Celano P., Booker S.V., Robinson C.R., and Offerhaus G.J. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N. Engl. J. Med. 328 (1993) 1313-1316
6. Dolara P., Caderni G., and Tonelli F. Nimesulide, a selective anti-inflammatory cyclooxygenase-2 inhibitor, does not affect polyp number and mucosal proliferation in familial adenomatous polyposis. Scand. J. Gastroenterol. 34 (1999) 1168
7. Steinbach G., Lynch P.M., Phillips R.K., Wallace M.H., Hawk E., Gordon G.B., Wakabayashi N., Saunders B., Shen Y., Fujimura T., Su L.K., and Levin B. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N. Engl. J. Med. 342 (2000) 1946-1952
8. Akasu T., Yokoyama T., Sugihara K., Fujita S., Moriya Y., and Kakizoe T. Peroral sustained-release indomethacin treatment for rectal adenomas in familial adenomatous polyposis: a pilot study. Hepatogastroenterology 49 (2002) 1259-1261
9. Mizushima N., Levine B., Cuervo A.M., and Klionsky D.J. Autophagy fights disease through cellular self-digestion. Nature 451 (2008) 1069-1075
10. Bialik S., and Kimchi A. Autophagy and tumor suppression: recent advances in understanding the link between autophagic cell death pathways and tumor development. Adv. Exp. Med. Biol. 615 (2008) 177-200
11. Ionov Y., Nowak N., Perucho M., Markowitz S., and Cowell J.K. Manipulation of nonsense mediated decay identifies gene mutations in colon cancer cells with microsatellite instability. Oncogene 23 (2004) 639-645
12. Kabeya Y., Mizushima N., Ueno T., Yamamoto A., Kirisako T., Noda T., Kominami E., Ohsumi Y., and Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19 (2000) 5720-5728
13. Paglin S., Hollister T., Delohery T., Hackett N., McMahill M., Sphicas E., Domingo D., and Yahalom J. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res. 61 (2001) 439-444
14. Munafó D.B., and Colombo M.I. A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation. J. Cell Sci. 114 (2001) 3619-3629
15. Rubinsztein D.C., Gestwicki J.E., Murphy L.O., and Klionsky D.J. Potential therapeutic applications of autophagy. Nat. Rev. Drug Discov. 6 (2007) 304-312
16. Wu W.K., Wu Y.C., Yu L., Li Z.J., Sung J.J., and Cho C.H. Induction of autophagy by proteasome inhibitor is associated with proliferative arrest in colon cancer cells. Biochem. Biophys. Res. Commun. 374 (2008) 258-263
17. Mizushima N., and Yoshimori T. How to interpret LC3 immunoblotting. Autophagy 3 (2007) 542-545
18. Backer J.M. The regulation and function of Class III PI3Ks: novel roles for Vps34. Biochem. J. 410 (2008) 1-17
19. Zhang Z., and DuBois R.N. Par-4, a proapoptotic gene, is regulated by NSAIDs in human colon carcinoma cells. Gastroenterology 118 (2000) 1012-1017
20. Martin S., Phillips D.C., Szekely-Szucs K., Elghazi L., Desmots F., and Houghton J.A. Cyclooxygenase-2 inhibition sensitizes human colon carcinoma cells to TRAIL-induced apoptosis through clustering of DR5 and concentrating death-inducing signaling complex components into ceramide-enriched caveolae. Cancer Res. 65 (2005) 11447-11458
21. Arico S., Pattingre S., Bauvy C., Gane P., Barbat A., Codogno P., and Ogier-Denis E. Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line. J. Biol. Chem. 277 (2002) 27613-27621
22. Wang M., Tan W., Zhou J., Leow J., Go M., Lee H.S., and Casey P.J. A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells. J. Biol. Chem. 283 (2008) 18678-18684
23. Yazbeck V.Y., Buglio D., Georgakis G.V., Li Y., Iwado E., Romaguera J.E., Kondo S., and Younes A. Temsirolimus downregulates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma. Exp. Hematol. 36 (2008) 443-450
24. Chen Q., Xie W., Kuhn D.J., Voorhees P.M., Lopez-Girona A., Mendy D., Corral L.G., Krenitsky V.P., Xu W., Moutouh-de Parseval L., Webb D.R., Mercurio F., Nakayama K.I., Nakayama K., and Orlowski R.Z. Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy. Blood 111 (2008) 4690-4699