Partitioning the loss in vancomycin binding affinity for D-Ala-D-Lac into lost H-bond and repulsive lone pair contributions

Journal of the American Chemical Society

Volumn 125, Issue 31, 2003, Pages 9314-9315

  McComas, Casey C ^a   Crowley, Brendan M ^a   Boger, Dale L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBENE; DEXTRO ALANYL DEXTRO LACTIC ACID; LACTIC ACID DERIVATIVE; UNCLASSIFIED DRUG; VANCOMYCIN; VANCOMYCIN AGLYCON; VANCOMYCIN DERIVATIVE;

ARTICLE; BINDING AFFINITY; DRUG BINDING; ELECTRICITY; ELECTRON; HYDROGEN BOND; HYDROPHOBICITY; REPULSIVE LONE PAIR; SOLVATION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTI-BACTERIAL AGENTS; DIPEPTIDES; HYDROGEN BONDING; KINETICS; LACTATES; OLIGOPEPTIDES; THERMODYNAMICS; VANCOMYCIN;

EID: 0042709547     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja035901x     Document Type: Article

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