Fractionation of a herbal antidiarrheal medicine reveals Eugenol as an inhibitor of Ca2+-activated Cl- channel TMEM16A

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Yao, Zhen ^a   Namkung, Wan ^a,b   Ko, Eun A ^a   Park, Jinhong ^b   Tradtrantip, Lukmanee ^a   Verkman, A S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Yonsei University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE CHANNEL; CLOVE OIL; EUGENOL; TMEM16A PROTEIN; UNCLASSIFIED DRUG; ANALGESIC AGENT; ANO1 PROTEIN, HUMAN; ANTIDIARRHEAL AGENT; ANTINEOPLASTIC AGENT; PLANT EXTRACT; TUMOR PROTEIN;

ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CHLORIDE CONDUCTANCE; CONTROLLED STUDY; DRUG FORMULATION; DRUG STRUCTURE; DRUG TARGETING; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; ILEUM; INTERSTITIAL CELL OF CAJAL; INTESTINE CONTRACTION; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; HUMAN;

SYZYGIUM AROMATICUM;

ANALGESICS; ANTIDIARRHEALS; ANTINEOPLASTIC AGENTS; CELL LINE; CHLORIDE CHANNELS; EUGENOL; HUMANS; NEOPLASM PROTEINS; PLANT EXTRACTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861582759     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038030     Document Type: Article

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