Eugenol precludes cutaneous chemical carcinogenesis in mouse by preventing oxidative stress and inflammation and by inducing apoptosis

Molecular Carcinogenesis

Volumn 49, Issue 3, 2010, Pages 290-301

  Kaur, Gurpreet ^a   Athar, Mohammad ^a,b   Sarwar Alam, M ^a  

^a HAMDARD UNIVERSITY   (India)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

12 O tetradecanoylphorbol 13 acetate (TPA); 7,12 dimethylbenz a anthracene (DMBA); Eugenol; Nuclear factor kappa B (NF B); Skin tumor

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLOOXYGENASE 2; EUGENOL; GLUTATHIONE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; PROSTAGLANDIN E2; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA; 7,12 DIMETHYLBENZ[A]ANTHRACENE; ANTIINFECTIVE AGENT; CARCINOGEN; ORNITHINE DECARBOXYLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFICACY; FEMALE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SKIN CARCINOGENESIS; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENZYME IMMUNOASSAY; LIPID PEROXIDATION; METABOLISM; PATHOLOGY; SKIN TUMOR; TUMOR CELL CULTURE; WESTERN BLOTTING;

MUS;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTI-INFECTIVE AGENTS; APOPTOSIS; BLOTTING, WESTERN; CARCINOGENS; CELL PROLIFERATION; EUGENOL; GLUTATHIONE; IMMUNOENZYME TECHNIQUES; INFLAMMATION; LIPID PEROXIDATION; MALE; MICE; ORNITHINE DECARBOXYLASE; OXIDATIVE STRESS; SKIN NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 77949907273     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20601     Document Type: Article

References (48)

1. Slaga TJ, Budunova IV, Gimenez-Conti IB, Aldaz CM. The mouse skin carcinogenesis model. J Invest Dermatol Symp Proc 1996;1:151-156.
2. Hennings H, Glick AB, Greenhalgh DA, et al. Critical aspects of initiation, promotion, and progression in multistage epidermal carcinogenesis. Proc Soc Exp Biol Med 1993; 202:1-8.
3. Yuspa SH, Długosz AA, Cheng CK, et al. Role of oncogenes and tumor suppressor genes in multistage carcinogenesis. J Invest Dermatol 1994;103:90S-95S.
4. Meulmeester E, Jochemsen AG. p53: A guide to apoptosis. Curr Cancer Drug Targets 2008;8:87-97.
5. Nishigori C. Cellular aspects of photocarcinogenesis. Photochem Photobiol Sci 2006;5:208-214.
6. DiGiovanni J. Multistage carcinogenesis in mouse skin. Pharmacol Ther 1992;54:63-128.
7. Bickers DR, Athar M. Oxidative stress in the pathogenesis of skin disease. J Invest Dermatol 2006;126:2565-2575.
8. Khan N, Afaq F, Mukhtar H. Cancer chemoprevention through dietary antioxidants: Progress and promise. Antioxid Redox Signal 2008;10:475-510.
9. Aggarwal BB, Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 2006;71:1397-1421.
10. IARC. 1985. Monograph, evaluation of carcinogenic risk of chemicals to humans, Vol. 36 Lyon, France: pp 75-97.
11. Benencia F, Courreges MC. In vitro and in vivo activity of eugenol on human herpesvirus. Phytother Res 2000;14: 495-500.
12. Sondak VK, Sabel MS, Mule JJ. Allogeneic and autologous melanoma vaccines: Where have we been and where are we going? Clin Cancer Res 2006;12:2337s-2341s.
13. Park BS, Song YS, Yee SB, et al. Phospho-ser 15-p53 translocates into mitochondria and interacts with Bcl-2 and Bcl-xL in eugenol-induced apoptosis. Apoptosis 2005;10: 193-200.
14. Ghosh R, Nadiminty L, Fitzpatrick JE, Alworth WL, Slaga TJ, Kumar AP. Eugenol causes melanoma growth suppression through inhibition of E2F1 transcriptional activity. J Biol Chem 2005;280:5812-5819.
15. Okada N, Hirata A, Murakami Y, Shoji M, Sakagami H, Fujisawa S. Induction of cytotoxicity and apoptosis and inhibition of cyclooxigenase-2 gene expression by eugenol-related compounds. Anticancer Res 2005;25:3263-3270.
16. Sukumaran K, Unnikrishnan MC, Kuttan R. Inhibition of tumour promotion in mice by eugenol. Indian J Physiol Pharmacol 1994;38:306-308.
17. Singh A, Singh SP, Bamezai R. Modulatory potential of clocimum oil on mouse skin papillomagenesis and the xenobiotic detoxication system. Food Chem Toxicol 1999; 36:663-670. (Pubitemid 29438567)
18. Azuine MA, Amonkar AJ, Bhide SV. Chemopreventive efficacy of betel leaf extract and its constituents on 7,12-dimethylbenz(a)anthracene induced carcinogenesis and their effect on drug detoxification system in mouse skin. Indian J Exp Biol 1991;24:346-351.
19. O'Brien TG. The induction of ornithine decarboxylase is an early, possibly obligatory event in mouse skin carcinogenesis. Cancer Res 1976;36:2644-2653.
20. Smart RC, Huang MT, Conney AH. sn-1,2,diacylglycerols mimic the effects of TPA in vivo by inducing biochemical changes associated with tumor promotion in mouse epidermis. Carcinogenesis 1986;7:1865-1870.
21. Wright JR, Colby HD, Miles PR. Cytosolic factors which affect microsomal lipid peroxidation in lung and liver. Arch Biochem Biophys 1981;206:296-304.
22. Jollow DJ, Mitchell JR, Zampaglione N, Gillete JR. Bromobenzene induced liver necrosis: Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic intermediate. Pharmacology 1974;11:151-169.
23. Mohandas J, Marshall JJ, Duggin GG, Horvath JS, Tiller D. Differential distribution of glutathione and glutathione related enzymes in rabbit kidney. Cancer Res 1984;44: 5086-5091.
24. Carlberg I, Mannervik B. Glutathione reductase levels in rat brain. J Biol Chem 1975;250:5475-5480.
25. Claiborne A. Catalase activity. In: Green Wald RA, editor. CRC handbook of methods for oxygen radical research. Boca Raton, FL: CRC Press; 1985. pp 283-284.
26. Habig WH, Pubst MJ, Jokoby WB. GST: The first enzymatic step in mercapturic acid formation. J Biol Chem 1974;249: 7130-7139.
27. Suzuki JS, Nishimura N, Zhang B, et al. Metallothionein deficiency enhances skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate in metallothionein-null mice. Carcinogenesis 2003;24:1123-1132.
28. Song HY, Lee JA, Ju SM, et al. Topical transduction of superoxide dismutase mediated by HIV-1 Tat protein transduction domain ameliorates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. Biochem Pharmacol 2008;75:1348-1357.
29. Barnes PJ, Karin M. Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997;336:1066-1071.
30. May MJ, Ghosh S. Signal transduction through NF-kappa B. Immunol Today 1998;19:80-88.
31. Zoumpourlis V. Alterations in signal transduction pathways implicated in tumour progression during multistage mouse skin carcinogenesis. Carcinogenesis 2003;24:1159-1165.
32. Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 2003;3:768-780.
33. Murphy FV, Sweet RM, Churchill ME. The structure of a chromosomal high mobility group protein-DNA complex reveals sequence-neutral mechanisms important for nonsequence-specificDNArecognition.EMBOJ 1999;18:6610-6618.
34. Han EH, Hwang YP, Jeong TC, Lee SS, Shin JG, Jeong HG. Eugenol inhibit 7,12-dimethylbenz[a]anthracene-induced genotoxicity in MCF-7 cells: Bifunctional effects on CYP1 and NAD(P)H:quinone oxidoreductase. FEBS Lett 2007;581: 749-756.
35. Hall PA, Levison DA, Woods AL, et al. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol 1990; 162:285-294.
36. Auvinen M. Cell transformation, invasion, and angiogenesis: A regulatory role for ornithine decarboxylase and polyamines? J Natl Cancer Inst 1997;89:533-537.
37. Auvinen M, Paasinen A, Andersson LC, Holtta E. Ornithine decarboxylase activity is critical for cell transformation. Nature 1992;360:355-358.
38. Mohan RR, Challa A, Gupta S, et al. Overexpression of ornithine decarboxylase in prostate cancer and prostatic fluid in humans. Clin Cancer Res 1999;5:143-147.
39. Surh YJ, Chun KS, Cha HH, et al. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: Down-regulation of COX-2 and iNOS through suppression of NF-kB activation. Mutat Res 2001; 480-481:243-268.
40. Chun KS, Cha HH, Shin HW, et al. Nitric oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-kB. Carcinogenesis 2004;25:445-454.
41. Chun KS, Keum YS, Han SS, Song YS, Kim SH, Surh YJ. Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-1 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kB activation. Carcinogenesis 2003;24:1515-1524.
42. Arroyo PL, Hatch-Pigott V, Mower HF, Cooney RV. Muta-genicity of nitric oxide and its inhibition by antioxidants. Mutat Res 1992;281:193-202.
43. Larcher F, Murillas R, Bolontrade M, Conti CJ, Jorcano JL. VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development. Oncogene 1998;17:303-311.
44. Harris RE. Cyclooxygenase-2 (cox-2) and the inflammogenesis of cancer. Subcell Biochem 2007;42:93-126.
45. Lee YY, Yang SF, Ho WH, Lee YH, Hung SL. Eugenol modulates cyclooxygenase-2 expression through the activation of nuclear factor kappa B in human osteoblasts. J Endod 2007;33:1177-1182.
46. Lee YY, Hung SL, Pai SF, Lee YH, Yang SF. Eugenol suppressed the expression of lipopolysaccharide-induced proinflammatory mediators in human macrophages. J Endod 2007;33:698-702.
47. Fujisawa S, Atsumi T, Kadoma Y, Sakagami H. Antioxidant and prooxidant action of eugenol-related compounds and their cytotoxicity. Toxicology 2002;177:39-54.
48. Lee WY, Lockniskar MF, Fischer SM. Interleukin-1 alpha mediates phorbol ester-induced inflammation and epidermal hyperplasia. FSEB J 1994;8:1081-1087.