In vivo anti-inflammatory action of eugenol on lipopolysaccharide-induced lung injury

Journal of Applied Physiology

Volumn 108, Issue 4, 2010, Pages 845-851

  Magalhães, Clarissa B ^a   Riva, Douglas R ^a   Depaula, Leonardo J ^a   Brando Lima, Aline ^a   Koatz, Vera Lúcia G ^a   Leal Cardoso, José Henrique ^b   Zin, Walter A ^a   Faffe, Débora S ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b STATE UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

Acute lung injury; Inflammation; Lung mechanics

Indexed keywords

EID: 77950554467     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00560.2009     Document Type: Article

References (32)

1. Asti C, Ruggieri V, Porzio S, Chiusaroli R, Melillo G, Caselli GF. Lipopolysaccharide-induced lung injury in mice. I. Concomitant evaluation of inflammatory cells and haemorrhagic lung damage. Pulm Pharmacol Ther 13: 61-69, 2000.
2. Bates JHT, Rossi A, Milic-Emili J. Analysis of the behavior of the respiratory system with constant inspiratory flow. J Appl Physiol 58: 1840-1848, 1985.
3. Birrell MA, McCluskie K, Wong S, Donnelly LE, Barnes PJ, Belvisi MA. Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NFκΒ-independent mechanism. FASEB J 19: 840-841, 2005. (Pubitemid 40617402)
4. Castellan RM, Olenchock SA, Kinsley KB, Hankinson JL. Inhaled endotoxin and decreased Spirometric values. An exposure-response relation for cotton dust. N Engl J Med 317: 605-610, 1987.
5. Chainy GBN, Manna SK, Chaturvedi MM, Aggarwal BB. Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-I, JNK, MAPKK and apoptosis. Oncogene 19: 2943-2950, 2000.
6. Covert MW, Leung TH, Gaston JE, Baltimore D. Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science 309: 1854-1857, 2005.
7. D'Acquisto F, Iuvone T, Rombolà L, Sautebin L, Di Rosa M, Carnuccio R. Involvement of NF-kappaB in the regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages. FEBS Lett 4.18: 175-178, 1997. (Pubitemid 27514441)
8. Faffe DS, Seidl VR, Chagas PSC, Gonçalves de Moraes VL, Capelozzi VL, Rocco PRM, Zin WA. Respiratory effects of lipopolysaccharideinduced inflammatory lung injury in mice. Eur Respir J 15: 85-91, 2000. (Pubitemid 30068941)
9. Fehrenbach H, Brasch F, Uhlig S, Weisser M, Stamme C, Wendel A, Richter J. Early alterations in intracellular and alveolar surfactant of the rat lung in response to endotoxin. Am J Respir Crit Care Med 157: 1630-1639, 1998. (Pubitemid 28242102)
10. Fischer IU, Dengler HJ. Sensitive high-performance liquid chromatographic assay for the determination of eugenol in body fluids. J Chromatogr 23: 369-377, 1990. (Pubitemid 20058966)
11. Ghaffar O, Hamid Q, Renzi PM, Allakhverdi Z, Molet S, Hogg JC, Shore SA, Luster AD, Lamkhioued B. Constitutive and cytokinestimulated expression of eotaxin by human airway smooth muscle cells. Am J Respir Crit Care Med 159: 1933-1942, 1999.
12. Gonçalves de Moraes VL, Singer M, Vargaftig BB, Chignard M. Effects of rolipram on cyclic AMP levels in alveolar macrophages and lipopolysaccharide-induced inflammation in mouse lung. Br J Pharmacol 123: 631-636, 1998. (Pubitemid 128515011)
13. Gonçalves de Moraes VL, Vargaftig BB, Lefort J, Meager A, Chignard M. Effect of cyclo-oxygenase inhibitors and modulators of cyclic AMP formation on lipopolysaccharide-induced neutrophil infiltration in mouse lung. Br J Pharmacol 117: 1792-1796, 1996. (Pubitemid 26121627)
14. Gundersen HJG, Bagger P, Bendtsen TF, Evans SM, Korbo L, Marcussen N, Møller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sorensen SB, Vesterby A, West MJ. The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 96: 857-881, 1988.
15. Karin M, Hunter T. Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus. Curr Biol 5: 747-757, 1995.
16. Lee YY, Hung SL, Pai SF, Lee YH, Yang SF. Eugenol suppressed the expression of lipopolysaccharide-induced proinflammatory mediators in human macrophages. J Endod 33: 698-702, 2007.
17. Lin YT, Wu BN, Horng CF, Huang YC, Hong SJ, Lo YC, Cheng CJ, Chen IJ. Isoeugenol: a selective betal-adrenergic antagonist with tracheal and vascular smooth muscle relaxant properties. Jpn J Pharmacol 80: 127-136, 1999.
18. Ma Q, Kinneer K. Chemoprotection by phenolic antioxidants. Inhibition of tumor necrosis factor alpha induction in macrophages. J Biol Chem 277: 2477-2484, 2002. (Pubitemid 34953270)
19. Menezes SLS, Bozza PT, Neto HCCF, Laranjeira AP, Negri EM, Capelozzi VL, Zin WA, Rocco PRM. Pulmonary and extrapulmonary acute lung injury: inflammatory and ultrastructural analyses. J Appl, Physiol 98: 1777-1783, 2005. (Pubitemid 40570789)
20. Michel O, Nagy AM, Schroeven M, Duchateau J, Nève J, Fondu P, Sergysels R. Dose-response relationship to inhaled endotoxin in normal subjects. Am J Respir Crit Care Med 156: 1157-1164, 1997. (Pubitemid 27446522)
21. l00 but does not induce degradation of IkappaBalpha/MAD3. J Virol 68: 8035-8044, 1994.
22. Murakami Y, Shoji M, Hanazawa S, Tanaka S, Fujisawa S. Preventive effect of bis -eugenol, a eugenol ortho dimer, on lipopolysaccharidestimulated nuclear factor kappaB activation and inflammatory cytokine expression in macrophages. Biochem Pharmacol 66: 1061-1066, 2003.
23. Murakami Y, Shoji M, Hirata A, Tanaka S, Yokoe I, Fujisawa S. Dehydrodiisoeugenol, an isoeugenol dimer, inhibits lipopolysaccharidestimulated nuclear factor kappaB activation and cyclooxygenase-2 expression in macrophages. Arch Biochem Biophys 434: 326-332, 2005. (Pubitemid 40082041)
24. Pauwels RA, Kips JC, Peleman RA, Van Der Straeten ME. The effect of endotoxin inhalation on airway responsiveness and cellular influx in rats. Am Rev Respir Dis 141: 540-545, 1990.
25. Rahman I, Biswas SK, Kirkham PA. Regulation of inflammation and redox signaling by dietary polyphenols. Biochem Pharmacol 72: 1439-1452, 2006. (Pubitemid 44666744)
26. Rocco PRM, Momesso DP, Figueira RC, Ferreira HC, Cadete RA, Légora-Machado A, Koatz VL, Lima LM, Barreiro EJ, Zin WA. Therapeutic potential of a new phosphodiesterase inhibitor in acute lung injury. Eur Respir J 22: 20-27, 2003. (Pubitemid 36896466)
27. Sandström T, Bjermer L, Rylander R. Lipopolysaccharide (LPS) inhalation in healthy subjects increases neutrophils, lymphocytes and fibronectin levels in bronchoalveolar lavage fluid. Eur Respir J 5: 992-996, 1992.
28. Santos FB, Nagato LKS, Boechem NM, Negri EM, Guimarães A, Capelozzi VL, Faffe DS, Zin WA, Rocco PRM. Time course of lung parenchyma remodeling in pulmonary and extrapulmonary acute lung injury. J Appl Physiol 100: 98-106, 2006. (Pubitemid 43671095)
29. Thorley AJ, Ford PA, Giembyez MA, Goldstraw P, Young A, Tetley TD. Differential regulation of cytokine release and leukocyte migration by lipopolysaccharide-stimulated primary human lung alveolar type II epithelial cells and macrophages. J Immunol 178: 463-473, 2007. (Pubitemid 46033630)
30. Ulich TR, Yin S, Remick DG, Russell D, Eisenberg SP, Kohno T. Intratracheal administration of endotoxin and cytokines. IV. The soluble tumor necrosis factor receptor type I inhibits acute inflammation. Am J Pathol 142: 1335-1338, 1993. (Pubitemid 24058119)
31. Watson RWG, Redmond HP, Bouchier-Hayes D. Role of endotoxin in mononuclear phagocyte-mediated inflammatory responses. J Leukoc Biol 56: 95-103, 1994. (Pubitemid 24241788)
32. Zhang P, Bagby GJ, Kolls JK, Welsh DA, Summer WR, Andresen J, Nelson S. The effects of granulocyte colony-stimulating factor and neutrophil recruitment on the pulmonary chemokine response to intratracheal endotoxin. J Immunol 165: 458-465, 2001. (Pubitemid 32038464)