Role of the C 8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 12, 2012, Pages 4084-4088

  Keck, Gary E ^a   Poudel, Yam B ^a   Rudra, Arnab ^a   Stephens, Jeffrey C ^a   Kedei, Noemi ^b   Lewin, Nancy E ^b   Blumberg, Peter M ^b  

^a UNIVERSITY OF UTAH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Alzheimer's disease; Bryostatin; Cancer; Phorbol ester; Protein kinase C

Indexed keywords

ANTINEOPLASTIC AGENT; BRYOSTATIN; MERLE 23; MERLE 27; MERLE 28; MERLE 30; MERLE 32; PROTEIN KINASE C; UNCLASSIFIED DRUG; BRYOSTATIN 1; ISOENZYME; PHORBOL 13 ACETATE 12 MYRISTATE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL CULTURE; DOWN REGULATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; CELL ADHESION; CELL PROLIFERATION; CHEMICAL STRUCTURE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BRYOSTATINS; CELL ADHESION; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; HUMANS; ISOENZYMES; MOLECULAR STRUCTURE; PROTEIN KINASE C; STRUCTURE-ACTIVITY RELATIONSHIP; TETRADECANOYLPHORBOL ACETATE;

EID: 84861574168     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.073     Document Type: Article

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