Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters

Organic Letters

Volumn 11, Issue 3, 2009, Pages 593-596

  Keck, Gary E ^a   Poudel, Yam B ^a   Welch, Dennie S ^c   Kraft, Matthew B ^a   Truong, Anh P ^d   Stephens, Jeffrey C ^a   Kedei, Noemi ^b   Lewin, Nancy E ^b   Blumberg, Peter M ^b  

^a UNIVERSITY OF UTAH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c ABBOTT LABORATORIES   (United States)

^d ELAN PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BRYOSTATIN; BRYOSTATIN 1; PHORBOL ESTER;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG SCREENING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; BRYOSTATINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; MOLECULAR STRUCTURE; PHORBOL ESTERS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 60849108068     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol8027253     Document Type: Article

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