Divergent effects of bryostatin 1 and phorbol myristate acetate on cell cycle arrest and maturation in human myelomonocytic leukemia cells (U937)

Differentiation

Volumn 63, Issue 1, 1998, Pages 33-42

  Vrana, Julie A ^a   Saunders, Aida M ^a   Chellappan, Srikumar P ^c   Grant, Steven ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Virginia Commonwealth College of Engineering   (United States)

^c New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

Anti proliferative effects; Bryostatin; P21(CIP1 WAF1); Phorbol ester; Proliferation control; Promyelocytic cells; U937 cells

Indexed keywords

BRYOSTATIN 1; CD11B ANTIGEN; CYCLIN DEPENDENT KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN P21;

ARTICLE; CELL ADHESION; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOSIS INHIBITION; MYELOMONOCYTIC LEUKEMIA; ONCOGENE C MYC; PRIORITY JOURNAL;

EID: 0031954011     PISSN: 03014681     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-0436.1998.6310033.x     Document Type: Article

References (53)

1. Aihara H, Asaoka Y, Yoshida K, Nishizuka Y (1991) Sustained activation of protein kinase C is essential to HL-60 cell differentiation to macrophage. Proc Natl Acad Sci USA 88: 11062-11066
2. Akiyama T, Yoshida T, Tsujita T, Shimizu M, Mizukami T, Okabe M, Akinaga S (1997) G1 phase accumulation induced UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1-WAF1-Sdi1 in p53-mutated human epidermoid carcinoma A431 cells. Cancer Res 57:1495-1501
3. Araki R, Komada T, Nakatani K, Naka M, Shima T, Tanaka T (1995) Protein kinase C-independent activation of Raf-1 and mitogen-activated protein kinase by leukotriene B4 in guinea pig eosinophils. Biochem Biophys Res Commun 210:837-843
4. Asiedu C, Biggs J, Lilly M, Kraft AS (1995) Inhibition of leukemic cell growth by the protein kinase C activator bryostatin 1 correlates with the dephosphorylation of cyclin-dependent kinase 2. Cancer Res 55:3716-3720
5. Bhatia U, Traganos F, Darzynkiewicz Z (1995) Induction of cell differentiation potentiates apoptosis triggered by prior exposure to DNA-damaging drugs. Cell Growth Differ 6:937-944
6. Blagosklonny MV, Probhu NS, El-Deiry WS (1997) Defects in p21/WAF1/CIP1, Rb, and c-myc signaling in phorbol ester-resistant cancer cells. Cancer Res 57:320-325
7. Carey JO, Posekany KJ, deVente JE, Pettit GR, Ways DK (1996) Phorbol-ester-stimulated phosphorylation of PU.1: association with leukemic cell growth inhibition. Blood 87: 4316-4324
8. Carroll MP, May WS (1994) Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells. J Biol Chem 269:1249-1256
9. Cayre Y, Raynal M-C, Darzynkiewicz A, Dorner MH (1987) Model for intermediate steps in monocytic differentiation: c-myc, c-fms, and ferritin as markers. Proc Natl Acad Sci USA 84:7619-7623
10. Chellappan SP (1994) The E2F transcription factor: role in cell cycle regulation and differentiation. Mol Cell Differ 2:201-220
11. Chellappan SP, Giordano A, Fisher PB (1998) The role of cyclin dependent kinases and their inhibitors in cellular differentiation and development. Curr Top Microbiol Immunol (in press)
12. Chelliah J, Freemerman AJ, Wu Pong S, Jarvis WD, Grant S (1997) Evidence of a role for c-myc in potentiation of 1-[β-D-arabinofuranosyl]cytosine-induced apoptosis by the protein kinase C activator bryostatin 1 in human myeloid leukemia cells. Biochem Pharm (54:563-573)
13. Fan J, Bertino JR (1997) K-ras modulates the cell cycle via both positive and negative regulatory pathways. Oncogene 14: 2595-2607
14. Freemerman AT, Maloney NJ, Birrer MJ, Szabo E, Grant S (1996) Bryostatin 1 potentiates 1-[β-D-arabinofuranosyl]cytosine-mediated antiproliferative effects in c-jun dominant-negative human myeloid leukemia cells (U937/TAM67) through a nonapoptotic mechanism. Mol Cell Differ 4:247-262
15. Freemerman AT, Vrana JA, Tombes RM, Jiang H, Chellapan SP, Fisher PB, Grant S (1997) Effects of antisense p21 (Waf1/Cip1/MDA6) expression on the responses of human myeloid leukemia cells (HL-60) to differentiation inducing and cytotoxic agents. Leukemia 11:504-513
16. Reference deleted
17. 1. Mol Cell Biol 8:1614-1624
18. Grant S, Jarvis WD, Swerdlow P, Turner A, Traylor T, Wallace H, Lin P-S, Pettit GR, Gewirtz DA (1992) Potentiation of the activity of 1-[β-D-arabinofuranosyl]cytosine by the macrocyclic lactone PKC activator bryostatin 1 is associated with enhanced fragmentation of mature DNA. Cancer Res 52:6270-6278
19. Grant S, Turner AJ, Freemerman AJ, Wang Z, Kramer L, Jarvis WD (1996) Modulation of protein kinase C activity and calcium-sensitive isoform expression in human myeloid leukemia cells by bryostatin 1: relationship to differentiation and Ara-C-induced apoptosis. Exp Cell Res 228:65-75
20. 1 cyclin-dependent kinases. Cell 75:805-816
21. Hocevar BA, Field AP (1991) Selective translocation of betaIi-protein kinase C to the nucleus of the human promyelocytic (HL-60) leukemia cells. J Biol Chem 266:28-33
22. Hoffmann B, Liebermann DA (1994) Molecular controls of apoptosis: differentiation/growth arrest primary response genes, proto-oncogenes, and tumor suppressor genes as positive and negative modulators. Oncogene 9:1807-1812
23. Huang Y, Waxman S (1994) Enhanced apoptosis in leukemia cells following treatment with combination fluoropyrimdines and differentiation inducers. Mol Cell Differ 2:83-100
24. Isakov N, Galron D, Mustelin T, Pettit GR, Altman A (1993) Inhibition of phorbol ester-induced T-cell proliferation by bryostatin is associated with rapid degradation of protein kinase C. J Immunol 150:1195-1204
25. Jarvis WD, Povirk LF, Turner AJ, Traylor RS, Gewirtz DA, Pettit GR, Grant S (1994) Effects of bryostatin 1 and other pharmacological activators of protein kinase C on 1-[β-D-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells. Biochem Pharmacol 47: 839-852
26. WAF1/CIP1. expression in the absence of p53. Oncogene 9:3397-3406
27. Kraft AS, Smith JB, Berkow RL (1986) Bryostatin an activator of the calcium phospholipid-dependent protein kinase blocks phorbol ester-induced differentiation of human promyelocytic leukemia cells HL-60. Proc Natl Acad Sci USA 83:1334-1338
28. Kraft AS, Baker VV, May WS (1987) Bryostatin induces changes in protein kinase C location and activity without altering c-myc gene expression in human promyelocytic leukemia cells (HL-60). Oncogene 1:111-118
29. Kraft AS, William F, Pettit GR, Lilly MB (1989) Varied differentiation responses of human leukemias to bryostatin 1. Cancer Res 49:1287-1293
30. Lee H-W, Smith L, Pettit GR, Smith JB (1996) Dephosphorylation of activated protein kinase C contribute to downregulation by bryostatin. Am J Physiol 271 :C304-C311
31. WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway. Cancer Res 56:31-35
32. Manfredi JJ, Tang H-Y, Waxman S (1996) The cyclin-dependent kinase inhibitor p21 as a target for differentiation therapy. Mol Cell Differ 4:33-45
33. Marquardt B, Frith D, Stabel S (1994) Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: reconstitution of the signalling pathway in vitro. Oncogene 9: 3213-3218
34. Martin SJ, Bradley JG, Cotter TG (1990) HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis. Clin Exp Immunol 79:448-453
35. Nevins JR (1992) E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-129
36. Ng SB, Guy GR (1992) Two protein kinase C activators, bryostatin-1 and phorbol-12-myristate-13-acetate, have different effects on haemopoietic cell proliferation and differentiation. Cell Signal 4:405-416
37. Pines J (1995) Cyclins and cyclin-dependent kinases: theme and variations. Adv Cancer Res 66:181-211
38. Pommier Y, Colburn N (1992) Acquisition of a growth-inhibitory response to phorbol ester involves DNA damage. Cancer Res 52:1907-1915
39. Reynisdottir I, Polyak K, Iavarone A, Massague J (1995) Kip/Cip and INK4 cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev 9:1831-1845
40. Schulte TW, Blagosklonny MV, Romanova I, Mushinski JF, Monia BP, Johnston JF, Nguyen P, Trepel J, Neckers LM (1996) Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway. Mol Cell Biol 16:5839-5845
41. Sherr CJ (1994) Gl phase progression: cycling on cue. Cell 79:551-555
42. Steube KG, Grunicke D, Quentmeier H, Drexler HG (1993) Divergent effects of the two protein kinase C activators bryostatin-1 and TPA on growth and differentiation of human monocytic leukemia cell lines. Leuk Res 17:897-901
43. Stone RM, Sariban E, Pettit GR, Kufe DW (1988) Bryostatin 1 activates protein kinase C and induces monocytic differentiation of HL-60 cells. Blood 72:208-213
44. 3 correlates with reduced rate of maturation of DNA replication intermediates. Cancer Res 51: 3451-3455
45. Sundstrom C, Nilsson K (1976) Establishment and characterization of a human histiocytic lymphoma cell line (U937). Int J Cancer 17:565-577
46. Szallasi Z, Smith CB, Pettit GR, Blumberg PM (1994) Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts. J Biol Chem 269:2118-2124
47. Toyoshima H, Hunter T (1994) p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21. Cell 78: 67-74
48. Vente J de, Kiley S, Garris T, Bryant W, Hooker J, Posekany K, Parker P, Cook P, Fletcher D, Ways DK (1995) Phorbol ester treatment of U937 cells with altered protein kinase C content and distribution induces cell death rather than differentiation. Cell Growth Differ 6:371-382
49. Waldman T, Lengauer C, Kinzler KW, Vogelstein B (1996) Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 381:713-716
50. 1-S phase block induced by 1,25 dihydroxyvitamin D, in HL-60 cells. Cancer Res 56:264-267
51. Won KA, Reed SI (1996) Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E. EMBO J 15:4182-4193
52. Yang GS, Minden MD, McCulloch EA (1993) Influence of schedule on regulated sensitivity of AML blasts to cytosine arabinoside. Leukemia 7:1012-1019
53. Zhang Y, Chellappan SP (1996) Transcriptional activation and expression of DP transcription factors during cell cycle and TPA-induced U937 differentiation. Mol Cell Differ 4:297-316