Integrated rapid resolution liquid chromatography-tandem mass spectrometric approach for screening and identification of metabolites of the potential anticancer agent 3,6,7-trimethoxyphenanthroindolizidine in rat urine

Analytica Chimica Acta

Volumn 731, Issue , 2012, Pages 60-67

  Tian, Yaping ^a   He, Jiuming ^a   Zhang, Ruiping ^a   Lv, Haining ^a   Ma, Shuanggang ^a   Chen, Yanhua ^a   Yu, Shishan ^a   Chen, Xiaoguang ^a   Wu, Yan ^a   He, Wenyi ^a   Abliz, Zeper ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Integrated analytical approach; Metabolite; Phenanthroindolizidine alkaloid; Potential anticancer agent; Rapid resolution liquid chromatography tandem mass spectrometry

Indexed keywords

ACCURATE MASS; ANALYTICAL APPROACH; ANTI-CANCER AGENTS; DATA MINING METHODS; DATA PROCESSING METHODS; DEMETHYLATION; DRUG METABOLITES; EXTRACTED ION CHROMATOGRAM; FRAGMENTATION PATTERNS; HIGH RESOLUTION; HIGH-THROUGHPUT; HYDROXYLATED METABOLITES; IN-VIVO; INTEGRATED APPROACH; ION SCAN; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MULTI-PERIOD; ORAL ADMINISTRATION; PHENANTHROINDOLIZIDINE ALKALOID; RAPID RESOLUTION; RAT URINE; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

BIOMOLECULES; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; DATA PROCESSING; IONS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NITROGEN COMPOUNDS; RATS;

METABOLITES;

3,6,7 TRIMETHOXYPHENANTHROINDOLIZIDINE; DRUG METABOLITE; INDOLIZIDINE ALKALOID; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DATA MINING; DEMETHYLATION; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; DRUG URINE LEVEL; FALSE POSITIVE RESULT; FRAGMENTATION REACTION; HIGH THROUGHPUT SCREENING; HYDROXYLATION; INFORMATION PROCESSING; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION; PRIORITY JOURNAL; RAT; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DATA MINING; INDOLIZIDINES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PHENANTHRENES; RATS; RATS, WISTAR; SYSTEMS INTEGRATION; TANDEM MASS SPECTROMETRY; TIME FACTORS; URINALYSIS;

RATTUS;

EID: 84861573619     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2012.04.024     Document Type: Article

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