Strategy of using microsome-based metabolite production to facilitate the identification of endogenous metabolites by liquid chromatography mass spectrometry

Analytica Chimica Acta

Volumn 685, Issue 1, 2011, Pages 36-44

  Clements, Melisa ^a   Li, Liang ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Endogenous metabolite; Human liver microsomes; LC MS; Metabolite identification; Metabolome analysis; Metabolomics

Indexed keywords

ENDOGENOUS METABOLITE; HUMAN LIVER MICROSOMES; LC-MS; METABOLITE IDENTIFICATION; METABOLOME ANALYSIS; METABOLOMICS;

BIOMOLECULES; ISOMERS; LIQUID CHROMATOGRAPHY; LIQUIDS; LIVER; MASS SPECTROMETRY; METABOLITES; STANDARDS; SUBSTRATES;

METABOLISM;

2 METHYLBUTYROYLCARNITINE; AMINO ACID DERIVATIVE; ASPARTYLPHENYLALANINE; HIPPURIC ACID DERIVATIVE; O METHOXYHIPPURIC ACID; O METHOXYHIPPURIC ACID METHYL ESTER; PALMITOYLCARNITINE; PHENYLACETYLGLYCINE; PHENYLACETYLGLYCINE METHYL ESTER; PHENYLALANINE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; FEASIBILITY STUDY; HUMAN; HUMAN TISSUE; INCUBATION TIME; LIQUID CHROMATOGRAPHY; LIVER METABOLISM; LIVER MICROSOME; METABOLITE; METABOLOMICS; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; URINALYSIS;

CHROMATOGRAPHY, LIQUID; HUMANS; METABOLOMICS; MICROSOMES, LIVER; TANDEM MASS SPECTROMETRY; URINALYSIS;

EID: 78650175324     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2010.11.014     Document Type: Article

References (31)

1. Want E.J., Nordstrom A., Morita H., Siuzdak G. J. Proteome Res. 2007, 6:459.
2. Metz T.O., Zhang Q.B., Page J.S., Shen Y.F., Callister S.J., Jacobs J.M., Smith R.D. Biomark. Med. 2007, 1:159.
3. Lu X., Zhao X.J., Bai C.M., Zhao C.X., Lu G., Xu G.M. J. Chromatogr. B 2008, 866:64.
4. Lu W., Bennett B.D., Rabinowitz J.D. J. Chromatogr. B 2008, 871:236.
5. Chen J., Wang W., Lv S., Yin P., Zhao X., Lu X., Zhang F., Xu G. Anal. Commun. 2009, 650:3.
6. Krug D., Zurek G., Schneider B., Garcia R., Müller R. Anal. Commun. 2008, 624:97.
7. Ji C.J., Walton J., Su Y., Tella M. Anal. Commun. 2010, 670:84.
8. Bollina V., Kumaraswamy G.K., Kushalappa A.C., Choo T.M., Dion Y., Rioux S., Faubert D., Hamzehzarghani H. Mol. Plant Pathol. 2010, 11:769.
9. Go E.P. J. Neuroimmune Pharm. 2010, 5:18.
10. Smith C.A., O'Maille G., Want E.J., Qin C., Trauger S.A., Brandon T.R., Custodio D.E., Abagyan R., Siuzdak G. Ther. Drug Monit. 2005, 27:747.
11. Wishart D.S., Tzur D., Knox C., Eisner R., Guo A.C., Young N., Cheng D., Jewell K., Arndt D., Sawhney S., Fung C., Nikolai L., Lewis M., Coutouly M.-A., Forsythe I., Tang P., Shrivastava S., Jeroncic K., Stothard P., Amegbey G., Block D., Hau D.D., Wagner J., Miniaci J., Clements M., Gebremedhin M., Guo N., Zhang Y., Duggan G.E., MacInnis G.D., Weljie A.M., Dowlatabadi R., Bamforth F., Clive D., Greiner R., Li L., Marrie T., Sykes B.D., Vogel H.J., Querengesser L. Nucleic Acids Res. 2007, 35:D521.
12. Wishart D.S., Knox C., Guo A.C., Eisner R., Young N., Gautam B., Hau D.D., Psychogios N., Dong E., Bouatra S., Mandal R., Sinelnikov I., Xia J.G., Jia L., Cruz J.A., Lim E., Sobsey C.A., Shrivastava S., Huang P., Liu P., Fang L., Peng J., Fradette R., Cheng D., Tzur D., Clements M., Lewis A., De Souza A., Zuniga A., Dawe M., Xiong Y.P., Clive D., Greiner R., Nazyrova A., Shaykhutdinov R., Li L., Vogel H.J., Forsythe I. Nucleic Acids Res. 2009, 37:D603.
13. N. Guo, Development of mass spectrometric techniques for protein sequencing and metabolome analysis, MSc in Chemistry, University of Alberta, Edmonton, 2006, p. 142.
14. Kamel A., Prakash C. Curr. Drug Metab. 2006, 7:837.
15. Nassar A.E.F., Talaat R.E. Drug Discov. Today 2004, 9:317.
16. Chowdhury S.K. Identification and Quantification of Drugs. Metabolites and Metabolizing Enzymes by LC-MS 2005, Elsevier Science BV.
17. Staack R.F., Hopfgartner G. Anal. Bioanal. Chem. 2007, 388:1365.
18. Brown C.M., Reisfeld B., Mayeno A.N. Drug Metab. Rev. 2008, 40:1.
19. Wilcoxen K.M., Uehara T., Myint K.T., Sato Y., Oda Y. Expert. Opin. Drug Discov. 2010, 5:249.
20. Shou W.Z., Zhang J. Expert Opin. Drug Metab. Toxicol. 2010, 6:321.
21. Baranczewski P., Stanczak A., Kautiainen A., Sandin P., Edlund P.O. Pharmacol. Rep. 2006, 58:341.
22. Holcapek M., Kolarova L., Nobilis M. Anal. Bioanal. Chem. 2008, 391:59.
23. Tang W., Wang R.W., Lu A.Y.H. Curr. Drug Metab. 2005, 6:503.
24. Baillie T.A. Chem. Res. Toxicol. 2008, 21:129.
25. Kumar S. Expert Opin. Drug Metab. Toxicol. 2010, 6:115.
26. Garg U., Hammett-Stabler C.A. Clinical Applications of Mass Spectrometry: METHODS AND PROTOCOLS 2010, Humana Press Inc. U. Garg, C.A. Hammett-Stabler (Eds.).
27. Nelson A.C., Huang W., Moody D.E. Drug Metab. Dispos. 2001, 29:319.
28. Shou W.Z., Magis L., Li A.C., Bryant M.S. J. Mass Spectrom. 2005, 40:1347.
29. Grupe A., Spiteller G. J. Chromatogr. 1981, 226:301.
30. Caldwell J., Sutton J.D. Food Sci. Technol. Int. 1988, 26:87.
31. Zuniga A., Li L. Proceedings of the American Society for Mass Spectrometry Conference 2010.