Detection and identification of 20-hydroxyecdysone metabolites in calf urine by liquid chromatography-high resolution or tandem mass spectrometry measurements and establishment of their kinetics of elimination after 20-hydroxyecdysone administration

Analytica Chimica Acta

Volumn 637, Issue 1-2, 2009, Pages 178-184

  Destrez, Blandine ^a   Pinel, Gaud ^a   Monteau, Fabrice ^a   Lafont, René ^b   Le Bizec, Bruno ^a  

^a Waters Corporation   (France)

^b SORBONNE UNIVERSITÉ   (France)

Author keywords

20 Hydroxyecdysone; Ecdysteroids; High resolution mass spectrometry; Kinetics of elimination; Liquid chromatography; Urine

Indexed keywords

20-HYDROXYECDYSONE; ANALYTICAL PROCEDURES; CALF URINES; CHEMICAL STRUCTURES; E ADMINISTRATIONS; ECDYSTEROIDS; EFFICIENT CONTROLS; FOOD-PRODUCING ANIMALS; HIGH RESOLUTIONS; HIGH-RESOLUTION MASS SPECTROMETRY; IN PLANTS; LC-MS/MS; LIQUID CHROMATOGRAPHY COUPLED TO TANDEM MASS SPECTROMETRIES; MASS SPECTRUM; SOLID-PHASE EXTRACTIONS; STEROID HORMONES; TANDEM MASS SPECTROMETRIES; TIME WINDOWS; URINE;

ANIMAL CELL CULTURE; ANIMALS; BIOCHEMISTRY; BIOMOLECULES; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; EXTRACTION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; HORMONES; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLISM; METABOLITES; SILICA; SOLAR RADIATION; SPECTRUM ANALYSIS;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ADMINISTRATION, ORAL; ANABOLIC AGENTS; ANIMALS; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ECDYSTERONE; KINETICS; MALE; SOLID PHASE EXTRACTION; SUBSTANCE ABUSE DETECTION; TANDEM MASS SPECTROMETRY;

ANIMALIA; BOS; BOVINAE; INVERTEBRATA;

EID: 61849180390     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2008.10.015     Document Type: Article

References (15)

1. Burdette W.J., and Richards R.C. Nature 189 (1961) 666-668
2. Syrov V.N., and Kurmukov A.G. Farmakologiya i Toksikologiya 39 (1976) 690-693
3. Syrov V.N. Biologicheskie Naukie 11 (1984) 16-20
4. Gadzhieva R.M., Portugalov S.N., Paniushkin V.V., and Kondrat E. Eksperimental'naya i Klinicheskaya Farmakologiya 58 (1995) 46-48
5. Sláma K., Koudela K., Tenora J., and Mathova A. Experientia 52 (1996) 702-706
6. Courtheyn D., Le Bizec B., Brambilla G., De Brabander H.F., Cobbaert E., Van De Wiele M., Vercammen J., and De Wasch K. Analytica Chimica Acta 473 (2002) 71-82
7. Le Bizec B., Antignac J.P., Monteau F., and André F. Analytica Chimica Acta 473 (2002) 89-97
8. Destrez B., Pinel G., Bichon E., Monteau F., Lafont R., and Le Bizec B. Rapid Communications in Mass Spectrometry 22 (2008) 1-8
9. Hikino H., Ohizumi Y., and Takemoto T. Chemical and Pharmaceutical Bulletin 20 (1972) 2454-2458
10. Lafont R., Girault J.P., and Kerb U. Biochemical Pharmacology 37 (1988) 1174-1177
11. Lafont R., Beydon P., Blais C., Garcia M., Lachaise F., Riera F., Sommé G., and Girault J.P. Insect Biochemistry 16 (1986) 11-16
12. Tsitsimpikou C., Tsami G.D., Siskos P.A., Spyridaki M.-H.E., and Georgakopoulos C.G. Rapid Communications in Mass Spectrometry 15 (2001) 1796-1801
13. F.W. Brandt, Faculty of Human Medicine, Ph.D., University of Marburg, Germany, 2003.
14. Le Bizec B., Montrade M.P., Monteau F., Gaudin I., and André F. Clinical Chemistry 44 (1998) 973-984
15. Girault J.P., Lafont R., and Kerb U. Drug Metabolism and Disposition 16 (1988) 716-720