Anticancer effect and neurotoxicity of S-(+)-deoxytylophorinidine, a new phenanthroindolizidine alkaloid that interacts with nucleic acids

Journal of Asian Natural Products Research

Volumn 13, Issue 5, 2011, Pages 400-408

  Liu, Zhen Jia ^a   Lv, Hai Ning ^b   Li, Hong Yan ^a   Zhang, Yi ^a   Zhang, Hai Jing ^a   Su, Fu Qin ^a   Si, Yi Kang ^a   Yu, Shi Shan ^b   Chen, Xiao Guang ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

anticancer; circular dichroism; neurotoxicity; nucleic acid; phenanthroindolizidine alkaloid; S (+) deoxytylophorinidine

Indexed keywords

CYCLOPHOSPHAMIDE; INDOLIZIDINE ALKALOID; NUCLEIC ACID; S DEOXYTYLOPHORINIDINE; UNCLASSIFIED DRUG; VINBLASTINE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MALE; MEDICINAL PLANT; MOUSE; NEUROTOXICITY; NONHUMAN; PLANT ROOT; RAT; TUMOR XENOGRAFT; TYLOPHORA; TYLOPHORA ATROFOLLICULATA; TYLOPHORA OVATA;

ALKALOIDS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; INDOLIZINES; MICE; NEUROTOXICITY SYNDROMES; NUCLEIC ACIDS; PC12 CELLS; PHENANTHROLINES; PLANT ROOTS; RATS; TRANSPLANTATION, HETEROLOGOUS; TYLOPHORA; VINBLASTINE;

TYLOPHORA ATROFOLLICULATA; TYLOPHORA OVATA;

EID: 79957865086     PISSN: 10286020     EISSN: 14772213     Source Type: Journal    
DOI: 10.1080/10286020.2011.566868     Document Type: Article

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