Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats

Molecular Brain

Volumn 5, Issue 1, 2012, Pages

  Yang, Jia Le ^a   Xu, Bo ^b   Li, Shuang Shuang ^c   Zhang, Wei Shi ^c   Xu, Hua ^c   Deng, Xiao Ming ^c   Zhang, Yu Qiu ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

2 1 subunit of Voltage gated calcium channels; CX3CL1; CX3CR1; Gabapentin; Glial activation; Monoarthritis

Indexed keywords

CALCIUM BINDING PROTEIN; CHEMOKINE RECEPTOR CX3CR1; FRACTALKINE; FREUND ADJUVANT; GABAPENTIN; GLIAL FIBRILLARY ACIDIC PROTEIN; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; HYPERALGESIA; IMMUNOFLUORESCENCE TEST; IMMUNOREACTIVITY; MALE; MICROGLIA; MONARTHRITIS; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SENSORY NERVE CELL; SPINAL CORD DORSAL HORN; UPREGULATION;

AMINES; ANIMALS; ARTHRITIS; CALCIUM CHANNELS, L-TYPE; CHEMOKINE CX3CL1; CYCLOHEXANECARBOXYLIC ACIDS; DISEASE MODELS, ANIMAL; FREUND'S ADJUVANT; GAMMA-AMINOBUTYRIC ACID; HYPERALGESIA; INJECTIONS, INTRA-ARTICULAR; INJECTIONS, INTRAPERITONEAL; LUMBAR VERTEBRAE; MALE; MICROGLIA; MODELS, BIOLOGICAL; PAIN; POSTERIOR HORN CELLS; PROTEIN SUBUNITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CHEMOKINE; SIGNAL TRANSDUCTION; SPINAL CORD; TIME FACTORS;

RATTUS;

EID: 84861562742     PISSN: None     EISSN: 17566606     Source Type: Journal    
DOI: 10.1186/1756-6606-5-18     Document Type: Article

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