Dexmedetomidine blocks thermal hyperalgesia and spinal glial activation in rat model of monoarthritis

Acta Pharmacologica Sinica

Volumn 31, Issue 5, 2010, Pages 523-530

  Xu, Bo ^a   Zhang, Wei Shi ^a   Yang, Jia Le ^b   Xu, Hua ^a   Deng, Xiao Ming ^a   Zhang, Yu Qiu ^b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Alpha 2 adrenergic receptor; Arthritis; Astrocyte; Dexmedetomidine; Pain modulation; Rats; Spinal cord

Indexed keywords

BIOLOGICAL MARKER; CELL MARKER; DEXMEDETOMIDINE; FREUND ADJUVANT; GLIAL FIBRILLARY ACIDIC PROTEIN; PROTEIN IBA 1; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANKLE; ARTICLE; ASTROCYTE; CELL ACTIVATION; CONTROLLED STUDY; DRUG MEGADOSE; FUNCTION TEST; GLIA CELL; HARGREAVE TEST; HYPERALGESIA; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LOW DRUG DOSE; MALE; MICROGLIA; MONARTHRITIS; NONHUMAN; PAIN ASSESSMENT; PROTEIN EXPRESSION; RAT; REPEATED DRUG DOSE; SPINAL CORD DORSAL HORN; THERMAL HYPERALGESIA; UPREGULATION;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; ARTHRITIS, EXPERIMENTAL; ASTROCYTES; CALCIUM-BINDING PROTEINS; DEXMEDETOMIDINE; FREUND'S ADJUVANT; GLIAL FIBRILLARY ACIDIC PROTEIN; HYPERALGESIA; MALE; MICROGLIA; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD;

EID: 77952024040     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.32     Document Type: Article

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